Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
121 Results for "
COS-7
" in MedChemExpress (MCE) Product Catalog:
Products (121)
121 Results for "COS-7" in MCE Product Catalog:
Cat. No.: HY-183732
CAS No.: 2841473-85-4
ATG5 PPI-IN-2 is a selective inhibitor of ATG5-TECAIR protein-protein interaction, with a IC50 of 19.16 μM. ATG5 PPI-IN-2 also acts as an Autophagy inhibitor .
Cat. No.: HY-183736
CAS No.: 2841473-93-4
Autophagy-IN-12 is a Autophagy inhibitor. Autophagy-IN-12 exhibits an IC50 value of >33 μM against the protein-protein interactions of ATG5-ATG16L1 and ATG5-TECAIR .
Cat. No.: HY-183828
CAS No.: 2841473-95-6
ATG5/TECAIR-IN-2 is an ATG5 inhibitor with target IC50 values >33 μM.ATG5/TECAIR-IN-2 disrupts protein-protein interactions between ATG5 and ATG16L1, and between ATG5 and TECAIR.ATG5/TECAIR-IN-2 inhibits autophagy in mammalian cells .
Cat. No.: HY-183829
CAS No.: 2841473-79-6
ATG5/TECAIR-IN-3 is a ATG5 inhibitor with autophagy inhibitory activity. ATG5/TECAIR-IN-3 selectively inhibits the ATG5-TECAIR interaction (IC50=31.24 μM) and shows no activity against the ATG5-ATG16L1 interaction .
Cat. No.: HY-183833
CAS No.: 2841473-77-4
Autophagy-IN-9 is a ATG5 inhibitor with an IC50 of 21.29 μM against ATG5-TECAIR. Autophagy-IN-9 blocks the binding of ATG5 to the hot-spot amino acid residues of TECAIR protein, disrupts the assembly of ATG5-related ternary complexes, inhibits autophagosome formation, and thereby downregulates cellular autophagy levels. Autophagy-IN-9 can be used in autophagy-related research, such as studies on infection .
Cat. No.: HY-183848
CAS No.: 2841473-98-9
ATG5/TECAIR-IN-4 is an ATG5-targeting autophagy inhibitor. ATG5/TECAIR-IN-4 exhibits weak autophagy inhibitory activity. ATG5/TECAIR-IN-4 could be used in cancer-related research .
Cat. No.: HY-183835
CAS No.: 2841473-75-2
Autophagy-IN-10 is an Autophagy inhibitor and an inhibitor of ATG5 interaction with other proteins, with an IC50 value of 2.29 μM against ATG5-ATG16L1 and an IC50 value of 3.68 μM against ATG5-TECAIR .
Cat. No.: HY-183737
CAS No.: 2841473-83-2
ATG5/TECAIR-IN-1 is a ATG5-TECAIR interaction inhibitor with an IC50 of 20.79 μM. ATG5/TECAIR-IN-1 inhibits autophagy. TG5/TECAIR-IN-1 is applicable to research on modulating protein-protein interactions to intervene in autophagy-related diseases, such as infectious diseases and cancers .
Cat. No.: HY-120580
CAS No.: 136668-50-3
Target:
Research Areas:
L 689037 is a leukotriene biosynthesis (LT) inhibitor and a 5-lipoxygenase-activating protein (FLAP) binder. [ 125I]-L 691,831 serves as a standard probe to precisely locate the key structural domains that determine the binding of inhibitors to FLAP. L 689037 can be used in the research of asthma and inflammatory bowel disease .
Target:
Research Areas:
(2-Fluorophenyl) diphenylmethanol is a IKCa1 channel blocker with a Kd value of 700 nM. (2-Fluorophenyl) diphenylmethanol is used in the research of graft-versus-host disease and inflammatory diseases .
Cat. No.: HY-135629
CAS No.: 1383376-93-9
Target:
Research Areas:
PF-5236216 is a brain-penetrant CK1δ/CK1ε inhibitor with IC50 values of 8 and 36 nM. PF-5236216 inhibits CK1δ and CK1ε-mediated PER3 nuclear translocation. PF-5236216 forms an H-bond with the backbone NH of Leu85, hydrophobic stacking with Met82, and a water-mediated H-bond with Lys38 of CK1δ. PF-5236216 can be used as a tool ligand for CNS PET studies .
Cat. No.: HY-183807
CAS No.: 2841473-81-0
T1742 is an autophagy inhibitor targeting ATG5. T1742 blocks and disrupts protein-protein interactions between ATG5 and ATG16L1, and between ATG5 and TECAIR.T 1742 inhibits autophagy in living cells via reduced autophagosome formation and downregulated ATG8-PE conjugation. T1742 can be used to study autophagy mechanisms .
Cat. No.: HY-183867
CAS No.: 2841473-87-6
ATG5 PPI-IN-6 is an inhibitor of ATG5 interactions with other proteins, with an IC50 value of 26.92 μM against ATG5-ATG16L1 and 16.34 μM against ATG5-TECAIR. ATG5 PPI-IN-6 inhibits Autophagy in cells .
Cat. No.: HY-D3086
CAS No.: 1668565-72-7
Target:
Research Areas:
Mito-polarity is a mitochondria-targeted polarity probe. Mito-polarity can be used to detect mitochondrial polarity. The detection mechanism of Mito-polarity is based on an intramolecular charge transfer (ICT) system designed with a donor-π-bridge-acceptor (D-π-A) structure. Among them, the 467 nm green emission generated by the Coumarin (HY-N0709) structure is extremely sensitive to polarity changes, while the 642 nm red emission produced by the extended π-conjugation and ICT effect between the Coumarin and benzothiazine structures shows only a weak response, thus forming a ratiometric fluorescence response that is linearly correlated with solvent polarity. When Mito-polarity is excited at 405 nm in methanol, its excitation/emission wavelengths are Ex/Em = 405/467 nm and Ex/Em = 405/642 nm, with maximum absorption wavelengths of 426 nm and 561 nm .
Cat. No.: HY-183838
CAS No.: 2841473-96-7
Autophagy-IN-11 is an ATG5-targeting autophage inhibitor. Autophagy-IN-11 disrupts protein-protein interactions between ATG5 and ATG16L1, and between ATG5 and TECAIR. Autophagy-IN-11 can be used for cancer research .
Cat. No.: HY-D2836K
Synonyms: FITC-Hyaluronate (MW 4000000)
Cat. No.: HY-D2836H
Synonyms: FITC-Hyaluronate (MW 7000)
Cat. No.: HY-127003
CAS No.: 18446-70-3
Target:
Cat. No.: HY-128319
CAS No.: 497926-94-0
Target:
Research Areas:
KM822 is a dopamine transporter (DAT) inhibitor with an IC50 of 2.2 μM against hDAT and an IC50 of 10.4 μM against C. elegans DAT-1. KM822 binds to the allosteric A2 site in the extracellular vestibule of outward-facing DAT, reduces the affinity of psychostimulants and phenethylamine psychostimulants for DAT, and inhibits dopamine transport function. KM822 attenuates the behaviors induced by psychostimulants and phenethylamine psychostimulants in planarians and C. elegans, does not induce locomotor effects on its own, and exhibits specificity for DAT. KM822 can serve as a molecular probe for investigating the allosteric regulation of DAT function. KM822 is applicable to studies related to psychostimulant use disorders .
Cat. No.: HY-182941
Target:
Research Areas:
Parawixin10 (Compound 2) is an N-acylpolyamine. Parawixin10 fails to enhance glutamate uptake in radioligand uptake assays of EAAT1, EAAT2 or EAAT3. Parawixin10 exhibits no positive allosteric modulatory activity in radioligand uptake assays of EAAT1−EAAT3, nor can it improve neuronal survival rates in mice in a dose-dependent and statistically significant manner. Parawixin10 has no neuroprotective activity .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
