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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
149 Results for "
Relative
" in MedChemExpress (MCE) Product Catalog:
Products (149)
149 Results for "Relative" in MCE Product Catalog:
Cat. No.: HY-90001S3
CAS No.: 1217720-20-1
Synonyms: rel-ABT 538-d6; rel-RTV-d6
Cat. No.: HY-10121D
CAS No.: 1261398-77-9
Synonyms: rel-Org 5222 hydrochloride
Domaines de recherche:
rel-Asenapine (rel-Org 5222) hydrochloride is a relative configuration of Asenapine hydrochloride (HY-16567). Asenapine (Org 5222) hydrochloride, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine hydrochloride can be used in the research of schizophrenia and bipolar disorder .
Cat. No.: HY-100689R
CAS No.: 263717-53-9
Synonyms: PPT (Standard)
Domaines de recherche:
Propyl pyrazole triol (Standard) is the analytical standard of Propyl pyrazole triol. This product is intended for research and analytical applications. Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) .
Cat. No.: HY-126115
CAS No.: 145773-22-4
Synonyms: 15-epi Latanoprost
Target:
Domaines de recherche:
15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.
Cat. No.: HY-131543S
Synonyms: RU 42698-d6
Cat. No.: HY-P82565
Synonyms: SORL1; C11orf32; Sortilin-related receptor; Low-density lipoprotein receptor Relative with 11 ligand-binding repeats; LDLR Relative with 11 ligand-binding repeats; LR11; SorLA-1; Sorting protein-related receptor containing LDLR class A repe
Cat. No.: HY-P85374
Synonyms: SORL1; C11orf32; Sortilin-related receptor; Low-density lipoprotein receptor Relative with 11 ligand-binding repeats; LDLR Relative with 11 ligand-binding repeats; LR11; SorLA-1; Sorting protein-related receptor containing LDLR class A repe
Cat. No.: HY-107409A
CAS No.: 2088424-87-5
Target:
Domaines de recherche:
rel-GNE 5729 is a relative configuration of GNE 5729 (HY-107409). GNE 5729 is a GluN2A-selective positive allosteric modulator .
Cat. No.: HY-19074
CAS No.: 83860-24-6
Target:
Domaines de recherche:
BMY-30047 is a retinoic acid derivative. BMY-30047 has topical retinoid activity. BMY-30047 has relative low local and systemic toxicity .
Cat. No.: HY-105281
CAS No.: 130200-44-1
Target:
Domaines de recherche:
rel-(E)-BMY 21950 sodium is the relative configuration of BMY 21950 (HY-105281A). BMY 21950 is an HMG-CoA reductase inhibitor. BMY 21950 inhibits hepatic cholesterol synthesis .
Cat. No.: HY-W716167
CAS No.: 570-19-4
Target:
Cat. No.: HY-N15768
CAS No.: 1917340-42-1
Category:
Target:
Cat. No.: HY-188043
CAS No.: 926623-28-1
Synonyms: Pte-Cys-ss-DAVLBH
Target:
Domaines de recherche:
EC216 is a folate receptor (FR) targeted conjugate that competes for binding at the FR site, with a relative binding affinity of 0.046. EC216 is applicable to studies related to folate receptor-targeted delivery and vinca alkaloid cytotoxins .
Cat. No.: HY-L917
5,619 compounds
RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs.
MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.
Cat. No.: HY-E71485
Target:
Domaines de recherche:
2-Aminophenol 1,6-dioxygenase (EC 1.13.11.74), a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent).
Cat. No.: HY-E71474
Target:
Domaines de recherche:
2-Amino-5-chlorophenol 1,6-dioxygenase (EC 1.13.11.76), a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent).
Cat. No.: HY-15322A
CAS No.: 1194954-52-3
Synonyms: (rel)-P505-15; (rel)-PRT-2607; (rel)-BIIB-057
Target:
Domaines de recherche:
(rel)-PRT062607 ((rel)-P505-15) is the relative configuration of PRT062607 (HY-15322). PRT062607 is a highly selective inhibitor of Syk kinase, with an IC50 value of 1-2 nM, and is more than 80 times less potent against Fgr, Lyn, FAK, Pyk2, and Zap70.
Cat. No.: HY-P11586
Target:
Domaines de recherche:
Cat. No.: HY-N18270
CAS No.: 1424881-06-0
Target:
Cat. No.: HY-P11831
Target:
Domaines de recherche:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
