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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
131 Results for "
exacerbations
" in MedChemExpress (MCE) Product Catalog:
Products (131)
131 Results for "exacerbations" in MCE Product Catalog:
Cat. No.: HY-B0024R
CAS No.: 123447-62-1
Synonyms: NM441 (Standard)
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Prulifloxacin (Standard) is the analytical standard of Prulifloxacin. This product is intended for research and analytical applications. Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a proagent of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis .
Cat. No.: HY-B1810R
CAS No.: 41570-61-0
Synonyms: C-78 free base (Standard)
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Tulobuterol (Standard) is the analytical standard of Tulobuterol. This product is intended for research and analytical applications. Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength .
Cat. No.: HY-66011BS
CAS No.: 2512220-27-6
Synonyms: (Rac)-BAY 12-8039-d4 free base
Cat. No.: HY-17452B
CAS No.: 1448435-17-3
Synonyms: Cefditoren pivoxyl hydrochloride; Cefditoren pivaloyloxymethyl ester hydrochloride; ME 1207 hydrochloride
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Cefditoren Pivoxil (ME 1207) hydrochloride is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
Cat. No.: HY-W011733R
CAS No.: 56776-01-3
Synonyms: C-78 (Standard)
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Tulobuterol (hydrochloride) (Standard) is the analytical standard of Tulobuterol (hydrochloride). This product is intended for research and analytical applications. Tulobuterol hydrochloride (C-78) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol hydrochloride is also a sympathomimetic agent used as a transdermal patch, increases normal diaphragm muscle strength . Tulobuterol hydrochloride inhibit rhinovirus replication and modulate airway inflammation .
Cat. No.: HY-A0062R
CAS No.: 191114-48-4
Synonyms: HMR3647 (Standard); RU66647 (Standard)
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Telithromycin (Standard) is the analytical standard of Telithromycin. This product is intended for research and analytical applications. Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to the ketolide family that is characterized by a keto group at position 3 of the macrolide ring and is active against bacteria causing community-acquired pneumonia, acute exacerbation of chronic bronchitis, and acute sinusitis. Telithromycin also has similar immunomodulatory effects as macrolides. Telithromycin can be used for the research of respiratory infections including bronchial asthma .
Cat. No.: HY-W740028
Synonyms: ME 1206-d3
Cat. No.: HY-17452AS
Synonyms: Cefditoren pivoxyl-d3; Cefditoren pivaloyloxymethyl ester-d3; ME 1207-d3
Cat. No.: HY-115860
CAS No.: 794544-99-3
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TAS-4 is a potent and selective mGluR4 positive allosteric modulator with significant anti-Parkinson's disease activity. TAS-4 is able to show efficacy when used alone or in combination with l-DOPA. TAS-4 is able to reverse haloperidol-induced spasticity when administered alone. TAS-4 enhances the contralateral rotation behavior induced by l-DOPA in a dose-dependent manner. TAS-4 combined with low-dose l-DOPA shows anti-Parkinson's effects similar to full-dose l-DOPA without exacerbating abnormal motor side effects .
Cat. No.: HY-176224
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Anti-virulence factor-IN-2 (compound C7) is an inhibitor targeting the virulence factor KpsM in Escherichia coli. kpsM mediates the translocation of capsular polysaccharides to the cell surface, allowing kpsM-positive E. coli to escape the phagocytosis of the scavenger receptor Marco on liver Kupffer cells, leading to bacterial dissemination. kpsM-positive E. coli exacerbates ethanol-induced liver disease. Anti-virulence factor-IN-2 can inhibit the ethanol-induced liver disease model caused by kpsM-dependent capsid in mice and has anti-infective activity. Anti-virulence factor-IN-2 can be used for the study of alcoholic hepatitis .
Cat. No.: HY-W026772S1
CAS No.: 35782-21-9
Cat. No.: HY-178374
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BACE-1/Mpro-IN-1 is a high brain-penetrant BACE-1 (IC50 = 0.26 μM) and SARS-CoV-2 Mpro (IC50 = 0.91 μM) dual inhibitor. BACE-1/Mpro-IN-1 binds to the aspartyl protease and cysteine protease as a mixed-type inhibitor. BACE-1/Mpro-IN-1 exhibits the most favorable docking score and a strong interaction profile. BACE-1/Mpro-IN-1 can be used for the study of COVID-19 exacerbated Neuroinflammation and Alzheimer’s disease .
Cat. No.: HY-W777458
CAS No.: 1189497-69-5
Cat. No.: HY-P992150
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Cat. No.: HY-66011CS
Synonyms: BAY 12-8039-d5 free base TFA
Research Areas:
Moxifloxacin-d5 (BAY 12-8039-d5) TFA is the deuterated-labeled Moxifloxacin TFA. Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the stud of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.
Cat. No.: HY-180415
CAS No.: 1274933-58-2
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UE2316 is an orally active and specific 11βHSD1 inhibitor. UE2316 significantly improves glucose tolerance and insulin sensitivity in uremic rats. UE2316 also exacerbates hepatic fibrosis in mice. UE2316 can be used in the research of diseases such as hepatic fibrosis, uremia and diabetes mellitus .
Cat. No.: HY-152940
CAS No.: 887907-50-8
Synonyms: C24:1 β-glucosylceramide
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βGlcCer is a glycosphingolipid. βGlcCer directly increases the development and PKCα and PKCδ activation in mouse bone marrow-derived DCs (BMDCs) . β-GlcCer accumulating in Gaucher disease activates microglia through macrophage-inducible C-type lectin (Mincle) to induce phagocytosis of living neurons, which exacerbates Gaucher symptoms .
Cat. No.: HY-189272
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ATR-IN-33 is an ATR kinase inhibitor (IC50 = 9.67 nM). ATR-IN-33 induces apoptosis, exacerbates DNA damage, and causes G1 phase cell cycle arrest by blocking CHK1 phosphorylation and DNA damage response signaling. ATR-IN-33 exhibits selective cytotoxicity against AML cell lines and can be used for research on acute myeloid leukemia .
Carbonic acid is a diprotic acid, acidulant and anesthetic. Carbonic acid penetrates living cells more easily than most other acids, exhibits stronger toxicity than inorganic acids at equivalent concentrations, and exacerbates ocean acidification. Carbonic acid binds reversibly to cellular proteins, acidifies cell sap and protoplasmic inclusions, inhibits Paramecium growth and various cellular functions, induces reversible cellular changes, produces lethal effects at high doses, decomposes into carbon dioxide and H2O, and participates in the maintenance of physiological pH balance .
Cat. No.: HY-189364
CAS No.: 88262-44-6
Synonyms: SMC247-9
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(DL)-3,5-Dimethyltyrosine (SMC247-9) is a selective APOBEC3B inhibitor optimized from SMC247, with an IC50 of 50 pM. (DL)-3,5-Dimethyltyrosine binds to the APOBEC3B protein, reduces intracellular APOBEC3B protein abundance partially through a lysosome-dependent pathway, enhances IL-15 expression in tumor cells, and relieves the suppression of CD8 + T cells by tumor cells in an IL-15-dependent manner. (DL)-3,5-Dimethyltyrosine attenuates tumor- and macrophage-derived chemokine-mediated macrophage chemotaxis and inhibits pathological myeloid inflammatory signaling. (DL)-3,5-Dimethyltyrosine inhibits tumor growth in the immune checkpoint blockade-responsive MC38 syngeneic mouse model and produces synergistic effects with anti-PD-L1 in the immune checkpoint blockade-resistant TC-1 tumor model; it also ameliorates anti-PD-1-exacerbated DSS-induced colitis-like intestinal inflammatory injury. (DL)-3,5-Dimethyltyrosine can be used in research related to tumor immunotherapy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
