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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
249 Results for "
shape-selective methylation
" in MedChemExpress (MCE) Product Catalog:
Products (249)
249 Results for "shape-selective methylation" in MCE Product Catalog:
Cat. No.: HY-P2592
CAS No.: 113714-78-6
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Cat. No.: HY-122635
CAS No.: 1597426-52-2
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T-448 free base is a specific, orally active, CNS-penetrant and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 free base enhances H3K4 methylation in primary cultured rat neurons .
Cat. No.: HY-P2252
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Cat. No.: HY-170523
CAS No.: 1358734-35-6
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RU-0415529 is an orally active inhibitor for SARS-CoV-2 nonstructural protein 14 (NSP14) with an IC50 of 356 nM. RU-0415529 binds to the SAH-stabilized cap binding pocket, inhibits viral RNA methylation and the viral replication. RU-0415529 exhibits anti-infectious activity in mouse models .
Cat. No.: HY-P2253
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Cat. No.: HY-E71200B
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16S rRNA (cytidine1402-2'-O)-Methyltransferase (EC 2.1.1.198) catalyses the 2'-O-methylation of cytidine1402 and RsmH (EC 2.1.1.199) catalyses the N4-methylation of cytidine1402 in 16S rRNA. Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.
Cat. No.: HY-E71200D
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16S rRNA (cytosine1402-N4)-Methyltransferase (EC 2.1.1.199) catalyses the N4-methylation of cytosine1402 andRsmI (EC 2.1.1.198) catalyses the 2'-O-methylation of cytosine1402 in 16S rRNA. Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.
Cat. No.: HY-E71453A
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23S rRNA (adenine2030-N6)-methyltransferase (EC 2.1.1.266) exhibits the highest methylation activity toward deproteinized 23S ribosomal subunits but shows no methylation activity toward fully assembled 50S subunits.
Cat. No.: HY-E71200
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16S rRNA (adenine1408-N1)-Methyltransferase (EC 2.1.1.180) provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N1-methylation at position adenine1408.
Cat. No.: HY-E71621
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2-Polyprenyl-6-hydroxyphenol methylase (EC 2.1.1.222): ubiG catalyses both methylation steps in ubiquinone biosynthesis in Escherichia coli.
Cat. No.: HY-E71452
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21S rRNA (uridine2791-2'-O)-Methyltransferase (EC 2.1.1.168) catalyses the methylation of uridine2791 of mitochondrial 21S rRNA.
Cat. No.: HY-E71766
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3-Methylquercetin 7-O-methyltransferase (EC 2.1.1.82) is a SAM-dependent O-methyltransferase (OMT) that catalyzes the methylation of the 7-O-hydroxyl group of flavonols.
Cat. No.: HY-103006R
CAS No.: 1612756-29-2
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NAI-N3 (Standard) is the analytical standard of NAI-N3 (HY-103006). This product is intended for research and analytical applications. NAI-N3 is a RNA acylation reagent that enables RNA purification. NAI-N3 is a dual-function SHAPE (selective 2-hydroxyl acylation and profiling experiment) probe (RNA structure probe and enrichment) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Cat. No.: HY-W013187
CAS No.: 21028-20-6
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3-Methylcytidine methosulfate is the methosulfate form of the N3-methylated cytidine analog 3-methylcytidine (HY-111645). 3-Methylcytidine methosulfate blocks the N3 site of cytidine via N3 methylation, generates steric hindrance, and reduces the basicity of the C4 amino group, thereby weakening its interaction with the allosteric site of E. coli ATCase. 3-Methylcytidine methosulfate can be used in studies of ATCase nucleotide recognition, allosteric regulation, and cytidine methylation .
Cat. No.: HY-E71453Q
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23S rRNA (guanosine2251-2'-O)-Methyltransferase (EC 2.1.1.185) catalyses the methylation of guanosine2251, a modification conserved in the peptidyltransferase domain of 23S rRNA.
Cat. No.: HY-E71453X
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23S rRNA (uridine2552-2'-O)-Methyltransferase (EC 2.1.1.166) catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA.
Cat. No.: HY-178102
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SKLB-0266 is the negative control of SKLB-0124 (HY-178114) (a PRMT6 inhibitor). SKLB-0266 after undergoing methylation modification completely loses its inhibitory activity against PRMT6 .
Cat. No.: HY-E71453B
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23S rRNA (adenine2085-N6)-dimethyltransferase (EC 2.1.1.184) is a methyltransferase that confers bacterial resistance to macrolide, lincosamide, and streptogramin B antibiotics by catalyzing the methylation of 23S rRNA at the adenine-2085 position.
Cat. No.: HY-185051
OTX-2002 is an mRNA encoding two bifunctional fusion proteins (ZFBD-MQ1 and ZFBD-KRAB). OTX-2002 targets regulatory elements located within the MYC protection gene domain (IGD) and induces the methylation of DNA and histone, leading to the downregulation of MYC expression.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
