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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
162 Results for "
TCF
" in MedChemExpress (MCE) Product Catalog:
Products (162)
162 Results for "TCF" in MCE Product Catalog:
Cat. No.: HY-P705932
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TEAD1; Protein GT-IIC; Prev. TCF13; TCF-13; Prev. AA; TEAD-1; Transcriptional Enhancer Factor TEF-1; Atrophia Areata, Peripapillary Chorioretinal Degeneration; TEF-1; TEA Domain Family Member 1; TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Fa
Species:
Human
Source:
HEK293
Research Areas:
Hexane-2,5-dione (2,5-HD) is an orally active, CNS-penetrant cytotoxic agent . Hexane-2,5-dione reduces BCL-2 and β-catenin/TCF transcriptional activity, increases BAX and active caspase-3 expression, and promotes apoptosis. Hexane-2,5-dione causes an accumulation of neurofilaments within axons in rats. Hexane-2,5-dione can be used for the research of neurodegenerative diseases .
Cat. No.: HY-P80413
Synonyms: IKKA, TCF16, CHUK, Inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, Nuclear factor NF-kappa-B inhibitor kinase alpha, Transcription factor 16, IKK-1, IKK1, NFKBIKA, TCF-16
Cat. No.: HY-181560
CAS No.: 2759011-75-9
Research Areas:
SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 (Kd: 4.52-7.49 nM). SLD1121 interacts with the intracellular domain of LRP6, stabilizes LRP6, promotes its nuclear translocation, and facilitates its binding to β-catenin, TCF4 or LEF1 in the nucleus, thereby inducing the expression of Wnt-regulated genes and stem cell-related genes. SLD1121 induces the transition of hair follicles from telogen to anagen in the mouse hair growth cycle and promotes hair growth in mice. SLD1121 is applicable to hair loss-related research .
Cat. No.: HY-P81357A
Synonyms: FOXA1; Forkhead box A1; Forkhead box protein A1; HNF-3-alpha; TCF3A; HNF3A; Transcription factor 3A
Cat. No.: HY-119590
CAS No.: 31501-55-0
Synonyms: Lonchocarpine
Cat. No.: HY-186001
CAS No.: 2922732-38-3
Synonyms: RM-044
RMC-9945 (RM-044) is a selective, covalent, and orally active RAS (ON) G12D inhibitor. RMC-9945 enhances the transcriptional activity of β-Catenin/TCF. RMC-9945 induces cell state transition, forcing metastatic colorectal cancer cells to switch from the Emp1 + state to the Lgr5 + stem cell-like state. RMC-9945 achieves durable disease control in preclinical models of colorectal cancer with early liver metastasis, but shows reduced activity in late-stage metastasis models. RMC-9945 can be used in research related to metastatic colorectal cancer and pancreatic ductal adenocarcinoma .
Cat. No.: HY-12238R
CAS No.: 1127442-82-3
Synonyms: endo-IWR 1 (Standard); IWR-1-endo (Standard)
Target:
Research Areas:
IWR-1 (Standard) is the analytical standard of IWR-1 (HY-12238). This product is intended for research and analytical applications. IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .
Cat. No.: HY-Y0315S
CAS No.: 97135-07-4
Synonyms: 2,5-HD-d10
Cat. No.: HY-P701139
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HNF4A; TCF-14; Prev. TCF14; Hepatocyte Nuclear Factor 4 4 Alpha Variant 4; Prev. MODY1; Hepatocyte Nuclear Factor 4 4 Alpha Variant 1; Prev. MODY; Hepatocyte Nuclear Factor 4 4 Alpha Variant 2; NR2A1; Truncated Hepatocyte Nuclear Factor 1 Alpha; HNF4; HNF
Species:
Human
Source:
HEK293
Cat. No.: HY-P705622
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TEAD1; Protein GT-IIC; Prev. TCF13; TCF-13; Prev. AA; TEAD-1; Transcriptional Enhancer Factor TEF-1; Atrophia Areata, Peripapillary Chorioretinal Degeneration; TEF-1; TEA Domain Family Member 1; TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor); REF1; Transcriptional Enhancer Factor 1; TEF1; Transcription Factor 13; TEA Domain Transcription Factor 1; NTEF-1
Species:
Human
Source:
HEK293
Cat. No.: HY-12238G
CAS No.: 1127442-82-3
Synonyms: endo-IWR 1 (GMP); IWR-1-endo (GMP)
Target:
Research Areas:
HB007 is a SUMO1 molecular glue degrader targeting CAPRIN1 and FBXO42. HB007 selectively binds CAPRIN1 to induce CAPRIN1-FBXO42 interaction, recruits SUMO1 to the CAPRIN1-CUL1-FBXO42 E3 ligase complex, and drives SUMO1 ubiquitination and degradation without affecting SUMO2/3. HB007 induces TCF4 deSUMOylation and proteasomal degradation to inhibit StarD7 transcriptional activity, reduces StarD7 mRNA and protein levels, and triggers ER stress and ROS production. HB007 can be used for the research of brain cancer, breast cancer, colon cancer, lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
