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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
160 Results for "
Orphan
" in MedChemExpress (MCE) Product Catalog:
Products (160)
160 Results for "Orphan" in MCE Product Catalog:
Cat. No.: HY-P83732
Synonyms: NR0B2; NR0B2_HUMAN; Nr0b2a; Nuclear receptor subfamily 0 group B member 2; Nuclear receptor subfamily 0, group B, member 2a; Orphan nuclear receptor SHP; SHP; SHP-1; Shp1; Small heterodimer partner.
Cat. No.: HY-P704094
Purity: ≥ 95%, as determined by HPLC.
Synonyms: APLNR; APJ (Apelin) Receptor; Prev. AGTRL1; G Protein-Coupled Receptor APJ; APJ; G-Protein Coupled Receptor APJ; APJR; HG11 Orphan Receptor; G-Protein Coupled Receptor HG11; APJ Receptor; Angiotensin II Receptor-Like 1; HG11; Angiotensin Receptor-Like 1;
Species:
Human
Source:
HEK293
Cat. No.: HY-P705991
Purity: ≥ 95%, as determined by HPLC.
Synonyms: APLNR; APJ (Apelin) Receptor; Prev. AGTRL1; G Protein-Coupled Receptor APJ; APJ; G-Protein Coupled Receptor APJ; APJR; HG11 Orphan Receptor; G-Protein Coupled Receptor HG11; APJ Receptor; Angiotensin II Receptor-Like 1; HG11; Angiotensin Receptor-Like 1;
Species:
Rhesus Macaque
Source:
HEK293
Cat. No.: HY-P77958
Purity: ≥ 95%, as determined by HPLC.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:
Human
Source:
HEK293
Cat. No.: HY-P77959
Purity: ≥ 95%, as determined by HPLC.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:
Human
Source:
HEK293
Cat. No.: HY-P700457
Purity: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:
Human
Source:
HEK293
Cat. No.: HY-P700537
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACKR3; Chemokine (C-X-C Motif) Receptor 7; Prev. CMKOR1; G-Protein Coupled Receptor 159; Prev. CXCR7; CXC-R7; GPR159; CXCR-7; RDC1; RDC-1; Chemokine Orphan Receptor 1; G Protein-Coupled Receptor; G-Protein Coupled Receptor RDC1 Homolog; Atypical Chemokine
Species:
Human
Source:
E. coli
Cat. No.: HY-P700731
Purity: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P700891
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; G-Protein Coupled Receptor HG38; Prev. GPR49; G-Protein Coupled Receptor 49; Prev. GPR67; G-Protein Coupled Receptor 67; HG38; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5, Isoform CRA_b; FEX; Orphan G Protein-Coupled Receptor HG38; L
Species:
Human
Source:
HEK293
Cat. No.: HY-P700998
Purity: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P703479
Synonyms: APLNR; APJ (Apelin) Receptor; Prev. AGTRL1; G Protein-Coupled Receptor APJ; APJ; G-Protein Coupled Receptor APJ; APJR; HG11 Orphan Receptor; G-Protein Coupled Receptor HG11; APJ Receptor; Angiotensin II Receptor-Like 1; HG11; Angiotensin Receptor-Like 1;
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P704647
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P704649
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:
Human
Source:
HEK293
Cat. No.: HY-P704758
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; G-Protein Coupled Receptor HG38; Prev. GPR49; G-Protein Coupled Receptor 49; Prev. GPR67; G-Protein Coupled Receptor 67; HG38; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5, Isoform CRA_b; FEX; Orphan G Protein-Coupled Receptor HG38; L
Species:
Human
Source:
HEK293
Cat. No.: HY-P704759
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; G-Protein Coupled Receptor HG38; Prev. GPR49; G-Protein Coupled Receptor 49; Prev. GPR67; G-Protein Coupled Receptor 67; HG38; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5, Isoform CRA_b; FEX; Orphan G Protein-Coupled Receptor HG38; L
Species:
Human
Source:
HEK293
Cat. No.: HY-P706156
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; G-Protein Coupled Receptor HG38; Prev. GPR49; G-Protein Coupled Receptor 49; Prev. GPR67; G-Protein Coupled Receptor 67; HG38; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5, Isoform CRA_b; FEX; Orphan G Protein-Coupled Receptor HG38; L
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P705025
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:
Human
Source:
HEK293
Cat. No.: HY-P811852
Synonyms: ESRRB; Estrogen Related Receptor Beta; NR3B2; ESRL2; ERR2; ERRb; Nuclear Receptor Subfamily 3 Group B Member; Steroid Hormone Receptor ERR2; Estrogen Receptor-Like; ERR Beta-2; ERRbeta; DFNB35; Estrogen-Related Nuclear Receptor Beta; Deafness, Autosomal Recessive 35; Estrogen-Related Receptor Beta; Orphan Nuclear Receptor; Nuclear Receptor ERRB2; ERRbeta2; ERR-Beta; ERRB2
Cat. No.: HY-P811852A
Synonyms: ESRRB; Estrogen Related Receptor Beta; NR3B2; ESRL2; ERR2; ERRb; Nuclear Receptor Subfamily 3 Group B Member; Steroid Hormone Receptor ERR2; Estrogen Receptor-Like; ERR Beta-2; ERRbeta; DFNB35; Estrogen-Related Nuclear Receptor Beta; Deafness, Autosomal Recessive 35; Estrogen-Related Receptor Beta; Orphan Nuclear Receptor; Nuclear Receptor ERRB2; ERRbeta2; ERR-Beta; ERRB2
Cat. No.: HY-L944
11028 compounds
MCE 18 stands for Medicinal Chemistry Evolution 2018. This metric was established based on structural data of 28,161 patented lead molecules, 1,370 marketed innovative drugs, and nearly 30,000 investigational candidates from preclinical to Phase III stages across 23 major global pharmaceutical companies from 1950 to 2018. After scaffold clustering analysis, a scoring model was constructed by integrating five three dimensional scaffold characteristics, including aromatic rings (AR), non aromatic heterocycles (NAR), chiral centers (CHIRAL), spirocycles (SPIRO), and the sp³ carbon ratio in cyclic and acyclic moieties, enabling quantitative assessment of molecular scaffold novelty and three dimensional complexity.
According to the score distribution of patented molecules, the top 25% of the original patent dataset was defined as the high novelty region. MCE 18 high scoring compounds selected based on this criterion can effectively avoid scaffold patent conflicts and intellectual property risks from the source. Molecules in this range typically feature a high sp³ carbon ratio, abundant chiral centers, spirocycles, and fused heterocycles with prominent three dimensional conformations. Their spatial properties allow precise matching to complex non traditional undruggable target pockets such as PPI interfaces and allosteric sites, making them ideal structural types for early stage screening of First in class drugs.
MCE‑18 Novelty Focused drug‑Like library strictly selects molecules from the aforementioned high scoring range, containing more than 10,000 premium drug like molecules with highly diverse scaffolds and rich 3D diversity. It can be used for high throughput screening of well established targets such as kinases, GPCRs, and proteases, and is especially suitable for hit identification in allosteric modulation, protein–protein interactions, and various undruggable orphan targets, fully supporting early stage drug discovery for cutting edge innovat
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
