153 Results for "

Orphan Receptor

" in MedChemExpress (MCE) Product Catalog:
Products (153)

153 Results for "Orphan Receptor" in MCE Product Catalog:

Cat. No.: HY-P1064A
Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC50 of 20 nM. Apelin-36(human) TFA shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC550=8.61). Apelin-36(human) TFA has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .
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Cat. No.: HY-P83732
Synonyms: NR0B2; NR0B2_HUMAN; Nr0b2a; Nuclear Receptor subfamily 0 group B member 2; Nuclear Receptor subfamily 0, group B, member 2a; Orphan nuclear Receptor SHP; SHP; SHP-1; Shp1; Small heterodimer partner.

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, ICC/IF

Reactivity:  

Mouse, Rat

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Cat. No.: HY-156190A
CAS No.: 452087-38-6
Purity:  99.34%
Research Areas:  

Cancer

NR2F2-IN-1 (free base) is a COUP-TFII (orphan nuclear receptor NR2F2) inhibitor with antitumor activity against prostate cancer. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators including FOXA1. NR2F2-IN-1 (free base) can be used for the research of prostate cancer .
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Cat. No.: HY-P77958
Purity:  ≥ 95%, as determined by HPLC.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P77959
Purity:  ≥ 95%, as determined by HPLC.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P700457
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P700731
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P700998
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P704647
Purity:  ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P704649
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-172769
Research Areas:  

Cancer

CM112 is a hydrophobic tag-based PRMT1 degrader (DC50 = 0.83 μM) with pan-inhibitory activity against type I PRMTs. CM112 induces proteasome-dependent degradation of PRMT1, inhibits the methyltransferase activities of PRMT1, PRMT3, PRMT4 and PRMT6, downregulates the stability of orphan receptor TR3, thereby interfering with the non-enzymatic scaffolding function of PRMT1. CM112 suppresses clonogenicity and proliferation of tumor cells. CM112 is applicable to research related to breast cancer and non-small cell lung cancer .
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Cat. No.: HY-P705025
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-N15721
CAS No.: 1630745-39-9
Synonyms: Trp-CA
Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-conjugated bile acid that acts as an endogenous ligand and agonist (EC50=9.6 μM) for the orphan G protein-coupled receptor (GPCR) MRGPRE (Mas-related G protein-coupled receptor family member E). Tryptophan-cholic acid is orally effective but has poor oral absorption and does not cross the blood-brain barrier. Tryptophan-cholic acid promotes the secretion of glucagon-like peptide GLP-1, thereby improving glucose tolerance in diabetic mice. Tryptophan-cholic acid improves glucose tolerance, promotes insulin secretion, and alleviates high-fat diet-induced hepatic steatosis without causing pruritus side effects. Tryptophan-cholic acid is primarily used in research on type 2 diabetes (T2D) .
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