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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
216 Results for "
junction
" in MedChemExpress (MCE) Product Catalog:
Products (216)
216 Results for "junction" in MCE Product Catalog:
Cat. No.: HY-141462
CAS No.: 13323-66-5
Target:
Cat. No.: HY-A0170R
CAS No.: 147059-72-1
Research Areas:
Trovafloxacin (Standard) is the analytical standard of Trovafloxacin. This product is intended for research and analytical applications. Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .
Category:
Alkaloids Other Diseases Phenols Polyphenols Plants Cissampelos pareira Disease Research Fields Isoquinoline Alkaloids Menispermaceae
Target:
Cat. No.: HY-184318
CAS No.: 915407-80-6
Target:
Research Areas:
GS-9160 is a HIV-1 integrase strand transfer inhibitor with an IC50 of 28 nM. GS-9160 elevates the level of HIV-1 double long terminal repeat circles and reduces integration junctions. GS-9160 exhibits selective antiviral activity against HIV-1 in cells. GS-9160 can select for integrase mutants E92V and L74M, and shows synergistic activity with other HIV-1 inhibitors. GS-9160 can be used in studies related to HIV-1 infection .
Research Areas:
3-Aminobenzoic acid (Standard) is the analytical standard of 3-Aminobenzoic acid. This product is intended for research and analytical applications. 3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, exhibiting anticonvulsant effects .
Cat. No.: HY-N1516R
CAS No.: 100665-43-8
Category:
Triterpenes Microorganisms Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants
Target:
Cat. No.: HY-K6022
MCE ECM Gentle Dissociation Solution is a gentle ECM-degrading enzyme mixture derived from marine bacteria and Bacillus species, specifically formulated for efficient and low-damage digestion of in-vitro cell systems. It selectively degrades extracellular matrix components while minimizing disruption to the cell membrane and intercellular junctions, thereby significantly reducing mechanical stress during dissociation. This product is compatible with a wide range of cell types, including stem cell colonies, primary cells, neural cells, and organoids, and is particularly well suited for gentle yet effective dissociation of brain organoids and other complex 3D structures.
Target:
Research Areas:
GDC-0134 (RG6000) is a modulator targeting dual leucine zipper kinase (DLK) that can cross the blood-brain barrier. By inhibiting the kinase activity of DLK, GDC-0134 blocks the activation of the downstream JNK signaling pathway, suppresses DLK-dependent retrograde signal transduction of axon-to-soma degeneration, and exerts neuroprotective activity. GDC-0134 reduces TDP-43 protein aggregation and decreases the degree of neuromuscular junction denervation in motor neurons. GDC-0134 can be used in the research of amyotrophic lateral sclerosis (ALS), Alzheimer's disease and other DLK-related neurodegenerative diseases .
Cat. No.: HY-187892
CAS No.: 3060541-19-4
Synonyms: ATH-1105
Target:
Research Areas:
Brelgometon (ATH-1105) is an orally active HGF/MET positive modulator . Brelgometon activates downstream ERK and AKT cascades. Brelgometon reduces pro-inflammatory cytokine levels and extranuclear TDP-43 aggregation; it also upregulates EAAT2 expression and improves mitochondrial function. Brelgometon protects neurons from excitotoxicity, inflammation, oxidative stress and mitochondrial dysfunction; it also maintains neurite length, neuromuscular junction integrity and sciatic nerve function. Brelgometon alleviates motor function deterioration, maintains body weight and prolongs survival in ALS transgenic mice. Brelgometon is applicable to research related to amyotrophic lateral sclerosis .
Category:
Stilbenes Polygonaceae Rheum officinale Baill. Phenols Plants Disease Research Fields Cancer
Target:
Target:
Research Areas:
Phospholipase A2 (PLA2), Crotalus adamanteus Venom is a membrane phospholipid-targeting enzyme. Phospholipase A2, Crotalus adamanteus catalyzes cleavage of the sn-2-acyl bond of membrane phospholipids, producing lysophospholipids and free fatty acids. Phospholipase A2, Crotalus adamanteus Venom can be used for biochemical research .
Cat. No.: HY-W663938
CAS No.: 400882-07-7
Research Areas:
Cyflumetofen is a non-systemic acylacetonitrile Acaricide. Cyflumetofen interferes with the Wnt/β-catenin signaling pathway, induces Apoptosis, and reduces the level of tight junction proteins. Cyflumetofen upregulates the expression of Pink1, Parkin and Lrrk2 genes associated with the pathogenesis of Parkinson's disease in zebrafish larvae. Cyflumetofen induces developmental toxicity and oxidative stress in zebrafish larvae, damages neurons, reduces motor activity, alters brain tissue structure, and disrupts blood-brain barrier structure. Cyflumetofen exhibits acaricidal activity against spider mites. Cyflumetofen can be used in studies related to Parkinson's disease and infestations by spider mites (Tetranychus urticae, Tetranychus kanzawai, Panonychus citri) .
Cat. No.: HY-P72226
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HJURP; 14-3-3-Associated AKT Substrate; Holliday junction Recognition Protein; Up-Regulated In Lung Cancer 9; URLC9; DKFZp762E1312; FAKTS; Fetal Liver Expressing Gene 1; HFLEG1; FLEG1; Fetal Liver-Expressing Gene 1 Protein
Species:
Human
Source:
E. coli
Cat. No.: HY-P5523
CAS No.: 592520-07-5
Research Areas:
Cat. No.: HY-P5523A
Research Areas:
Cat. No.: HY-P991588
CAS No.: 2851060-90-5
Synonyms: AC101
Cat. No.: HY-P70385
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: JAM2; CD322; Prev. C21orf43; VEJAM; VE-JAM; JAM-IT/VE-JAM; JAM-B; CD322 Antigen; JAM-2; PRO245; Vascular Endothelial junction-Associated Molecule; IBGC8; junctional Adhesion Molecule B; junctional Adhesion Molecule 2; JAMB
Species:
Human
Source:
HEK293
Cat. No.: HY-P73259
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: JAM2; CD322; Prev. C21orf43; VEJAM; VE-JAM; JAM-IT/VE-JAM; JAM-B; CD322 Antigen; JAM-2; PRO245; Vascular Endothelial junction-Associated Molecule; IBGC8; junctional Adhesion Molecule B; junctional Adhesion Molecule 2; JAMB
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73260
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: JAM2; CD322; Prev. C21orf43; VEJAM; VE-JAM; JAM-IT/VE-JAM; JAM-B; CD322 Antigen; JAM-2; PRO245; Vascular Endothelial junction-Associated Molecule; IBGC8; junctional Adhesion Molecule B; junctional Adhesion Molecule 2; JAMB
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73261
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: JAM2; CD322; Prev. C21orf43; VEJAM; VE-JAM; JAM-IT/VE-JAM; JAM-B; CD322 Antigen; JAM-2; PRO245; Vascular Endothelial junction-Associated Molecule; IBGC8; junctional Adhesion Molecule B; junctional Adhesion Molecule 2; JAMB
Species:
Rat
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
