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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
195 Results for "
outer
" in MedChemExpress (MCE) Product Catalog:
Products (195)
195 Results for "outer" in MCE Product Catalog:
Cat. No.: HY-W654100
Cat. No.: HY-L029
2,080 compounds
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.
MCE provides a unique collection of 2,080 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.
Cat. No.: HY-108595R
CAS No.: 313505-85-0
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VU590 (Standard) is the analytical standard of VU590 (HY-108595). This product is intended for research and analytical applications. VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the Kidney .
Cat. No.: HY-110076
CAS No.: 1783987-83-6
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VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 dihydrochloride is not a good probe of ROMK function in the kidney .
Cat. No.: HY-185180
CAS No.: 14836-73-8
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Ferrioxamine B is a bacterial desferrioxamine siderophore produced by actinomycetes. Ferrioxamine B acts as a ligand for FpvB and FoxA, and is transported into Pseudomonas aeruginosa via the FpvB and FoxA transporters. Ferrioxamine B competitively binds to FpvB, thereby antagonizing the uptake of thiostrepton into Pseudomonas aeruginosa. Ferrioxamine B can provide an iron source to support the growth of Pseudomonas aeruginosa under iron-limiting conditions .
Cat. No.: HY-122658
CAS No.: 373370-73-1
Synonyms: MB-1
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MitoBloCK-1 (MB-1) is an inhibitor that blocks the import of substrates that use the TIM22 import pathway. MitoBloCK-1 inhibits import by preventing binding of substrate to tim9/10 complex to the substrate, thus the substrate failed to be reach the TIM22 translocon. MitoBloCK-1 inhibits protein import of TIM22 substrates into mitochondria. MitoBloCK-1 attenuates the import of the carrier proteins including the ADP/ATP and phosphate carriers. MitoBloCK-1 also inhibits the import of an additional carrier protein, PiC, and the outer membrane protein Tom40 .
Cat. No.: HY-144255
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Antibacterial agent 70 is an antibacterial agent that interacts with DNA, with a MIC value of 0.5 μg/mL against K. pneumonia and A. baumanii. Antibacterial agent 70 exhibits rapid bactericidal activity, low cytotoxicity to mammalian cells, and low tendency to induce drug resistance. Antibacterial agent 70 intercalates into DNA, disrupts bacterial membrane integrity, increases intracellular ROS production, reduces GSH activity, regulates membrane depolarization, enhances outer membrane permeability, and induces inner membrane damage. Antibacterial agent 70 can be used in studies related to multidrug-resistant bacterial infections and infections caused by drug-resistant Gram-negative pathogens .
Cat. No.: HY-P11733
peptide nucleic acid. (KFF)3K-acpP binds to the translation start site region of acpP mRNA, sterically blocking ribosome binding and inhibiting translation of the acyl carrier protein. (KFF)3K-acpP induces bacterial envelope stress response pathways, and triggers depletion of outer membrane protein F (ompF) transcript. (KFF)3K-acpP can be used for the research of infections .
Cat. No.: HY-182020
LpxH-IN-3 is a Klebsiella pneumoniae LpxH inhibitor with an IC50 of 0.17 μM. LpxH-IN-3 binds to the L-shaped hydrophobic binding pocket of Klebsiella pneumoniae LpxH, forms hydrogen bonds and other interactions with key residues, disrupts lipid A biosynthesis, and induces bacterial death. LpxH-IN-3 exhibits moderate antibacterial activity against Klebsiella pneumoniae and Escherichia coli. LpxH-IN-3 can be used for the research of klebsiella pneumoniae infection .
Cat. No.: HY-202273
CAS No.: 37280-35-6
Capreomycin IA is a bactericidal agent targeting bacterial ribosomes, with activity limited primarily to mycobacteria. Capreomycin IA blocks translocation of peptidyl-transfer RNA from the A to the P site to inhibit protein synthesis. Capreomycin IA exerts activity against Mycobacterium tuberculosis. Capreomycin IA can be used for the research of tuberculosis .
Cat. No.: HY-D3446
CAS No.: 2358677-26-4
Cat. No.: HY-184639
Carboxylated magnetic microspheres (low nonspecificity) are functionalized nano- or micron-sized magnetic particles with abundant carboxyl functional groups on their surface. Special chemical treatments reduce the likelihood of nonspecific adsorption. This 1μm carboxylated magnetic microsphere features a core-shell structure: a PS core, an outer layer of iron oxide (Fe3O4), and an outermost encapsulation layer. The carboxyl groups are obtained through polymer modification. Exhibiting low nonspecific adsorption, these microspheres can covalently couple with bioligands such as peptides, proteins, antibodies, and oligonucleotides using specific chemical reagents (e.g., EDC), making them particularly suitable for cell sorting, affinity chromatography, and immunoassay.
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Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .
Cat. No.: HY-P11468
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Cat. No.: HY-W009123
CAS No.: 112-84-5
Synonyms: cis-13-Docosenamide
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Erucamide is an orally active, blood-brain barrier-permeable TMEM19 ligand and T3SS inhibitor. Erucamide exerts retinal neuroprotective effects in mouse models of retinal degeneration. Erucamide attenuates depression- and anxiety-like behaviors in mice.\n\nErucamide binds to the conserved hydrophobic pocket in HrcC, disrupts its outer membrane localization, and blocks T3SS-mediated effector protein secretion in Gram-negative pathogenic bacteria. Erucamide enhances the antimicrobial immunity of plants against pathogenic bacteria. Erucamide can be used in research related to retinitis pigmentosa, anxiety and depression, bacterial wilt, and bacterial blight .
Cat. No.: HY-175664
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EYE-003 is an orally active RPE65 inhibitor with an IC50 of 102 nM. EYE-003 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-003 suppresses scotopic ERG b-wave amplitude and exerts protective effects against retinal degeneration in Abca4 ⁻/⁻ Rdh8 ⁻/⁻ mice (a STGD1 model) by reducing retinal autofluorescent puncta and preserving outer nuclear layer (ONL) thickness in a dose-dependent manner. EYE-003 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .
Cat. No.: HY-B0764R
CAS No.: 16980-89-5
Synonyms: Dibutyryl cAMP sodium (Standard); DBcAMP sodium (Standard)
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Bucladesine (Dibutyryl cAMP; DBcAMP) sodium (Standard) is the analytical standard of Bucladesine sodiumn (HY-B0764). This product is intended for research and analytical applications. Bucladesine is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .
Cat. No.: HY-D3573
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AF488 C5 Maleimide is a thiol-reactive Fluorescent dye used to label target proteins and bacterial structures. AF488 C5 Maleimide irreversibly forms covalent thioether conjugates with cysteine thiol groups. AF488 C5 Maleimide stabilizes pre-formed globular low-molecular-weight Tau protein oligomers by blocking cysteine-dependent tau protein aggregation, allowing observation of the internalization process of tau protein oligomers into neuronal cells via confocal microscopy. AF488 C5 Maleimide can label cysteine-modified pili; the outer membrane permeability varies among different bacterial species, allowing imaging via epifluorescence microscopy using a FITC filter set .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
