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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
α1D adrenoceptor
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "α1D adrenoceptor" in MCE Product Catalog:
38
38 Publications Verification
Synonyms: (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride
Category:
Cardiovascular Disease Plants Endogenous metabolite Alkaloids Monophenols Other Alkaloids Verbenaceae Phenols Disease Research Fields Endocrinology Lippia thymoides Mart. & Schauer
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3 Cited Publications
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BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist .
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Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia .
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1 Cited Publications
Cat. No.: HY-B0391B
CAS No.: 1164469-60-6
Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride
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Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia .
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ADRA1D receptor antagonist 1 is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM .
Cat. No.: HY-U00399A
CAS No.: 208992-74-9
Synonyms: ABT 980
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Fiduxosin hydrochloride (ABT 980) is a potent α1-adrenoceptor antagonist, with Ki of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively .
Cat. No.: HY-B0371B
CAS No.: 109351-34-0
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(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent α1-adrenoceptor antagonist with Ki values of 6.51 nM, 1.01 nM and 1.97 nM for α1a, α1b and α1d-adrenoceptor, respectively .
Synonyms: (R)-(-)-Phenylephrine hydrochloride (Standard); L-Phenylephrine hydrochloride (Standard)
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RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia .
Cat. No.: HY-B0371D
CAS No.: 109351-33-9
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(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity α-adrenoceptor antagonist with Ki values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, α1b and α1d-adrenoceptor, respectively. (S)-Terazosin also has high-affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 729 nM, 3.5 nM and 46.4 nM, respectively .
Cat. No.: HY-U00399
CAS No.: 208993-54-8
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Fiduxosin is a potent α1-adrenoceptor antagonist, with Ki of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively.
Cat. No.: HY-19268
CAS No.: 179535-60-5
Synonyms: GW 1818
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GG-818 (GW 1818) is a potent and selective α1 adrenoceptor antagonist, with pKi values of 9.7 for α1a, 7.8 for α1b, and 7.6 for α1d. GG-818 (GW 1818) can be used for benign prostatic hyperplasia research .
Cat. No.: HY-B0471S
CAS No.: 1217858-50-8
Synonyms: (R)-(-)-Phenylephrine-d3 hydrochloride; L-Phenylephrine-d3 hydrochloride
Cat. No.: HY-B0471S1
CAS No.: 1276197-50-2
Synonyms: (R)-(-)-Phenylephrine-2,4,6-d3 hydrochloride; L-Phenylephrine-2,4,6-d3 hydrochloride
Cat. No.: HY-B0391A
CAS No.: 57149-08-3
Synonyms: KT-611 dihydrochloride; BM-15275 dihydrochloride
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Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia .
Cat. No.: HY-103209
CAS No.: 173059-17-1
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Rec 15/2615 hydrochloride is a potent and selective α-1B adrenoceptor antagonist with Ki values of 1.9 nM, 0.3 nM, 2.6 nM for α1A, α1B, α1D, respectively. Rec 15/2615 hydrochloride modulates vaginal smooth muscle contractility and genital engorgement .
Cat. No.: HY-123514
CAS No.: 255893-38-0
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SNAP8719 free base is a selective α1D-adrenoceptor antagonist (pKi = 8.89). SNAP8719 free base shows affinity for the dopamine D2-, 5-HT1A-, and the human clonal α2a-adrenoceptor, with pKi values of 5.98, 6.47, and <5.0, respectively. SNAP8719 free base causes a concentration-dependent increase in the twitch response .
Cat. No.: HY-W724254
CAS No.: 252201-38-0
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SNAP-6201 is a selective α1a adrenoceptor antagonist with a Ki of 0.2 nM. SNAP-6201 exhibits >1400-fold selectivity over α1b and α1d adrenoceptors. SNAP-6201 exhibits excellent selectively to inhibit intraurethral pressure (IUP) in the anesthetized dog model. SNAP-6201 can be used for benign prostatic hyperplasia (BPH) research .
Cat. No.: HY-116982
CAS No.: 21102-94-3
Target:
BMY 7378 (free base) is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 (free base) binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 (free base) is a 5-HT1A receptor partial agonist .
Cat. No.: HY-B0471S3
CAS No.: 1089675-56-8
Synonyms: (R)-(-)-Phenylephrine-d6 hydrochloride; L-Phenylephrine-d6 hydrochloride
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
