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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
β-hexosaminidase release
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "β-hexosaminidase release" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-172458
CAS No.: 473687-20-6
Research Areas:
Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a KD value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions .
Cat. No.: HY-N10093
CAS No.: 69618-96-8
Synonyms: Chamaejasmin
Cat. No.: HY-113242
CAS No.: 35176-46-6
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Cat. No.: HY-P1793
CAS No.: 83471-50-5
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Cat. No.: HY-P991651
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Cat. No.: HY-N15708
CAS No.: 755036-45-4
Synonyms: (R)-(-)-Dichotomine C
Cat. No.: HY-N3815
CAS No.: 921211-29-2
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Cat. No.: HY-P1793A
Research Areas:
Cat. No.: HY-N8426
CAS No.: 79004-25-4
Synonyms: Ellisinin A
Target:
Cat. No.: HY-N12116
CAS No.: 1967042-42-7
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Cat. No.: HY-N12261
CAS No.: 138968-86-2
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Cat. No.: HY-P11163
CAS No.: 255720-68-4
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Cat. No.: HY-N16668
CAS No.: 718638-77-8
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MRS2690 is a selective P2Y14 receptor agonist. MRS2690 inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 induces intracellular calcium mobilization, activates P38 and stimulates [ 35S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690can be used for ischemic heart disease .
Cat. No.: HY-116295A
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MRS2690 disodium is a selective P2Y14 receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [ 35S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease .
Cat. No.: HY-N18182
CAS No.: 172705-25-8
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Cat. No.: HY-181891
CAS No.: 3107904-58-2
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XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases .
Cat. No.: HY-N11725
CAS No.: 128129-56-6
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Cat. No.: HY-149151
CAS No.: 20988-30-1
Category:
Cat. No.: HY-185402
CAS No.: 3116848-78-0
Research Areas:
MrgprX2 antagonist-10 is a potent MRGPRX2 antagonist. MrgprX2 antagonist-10 inhibits MRGPRX2-mediated accumulation and mast cell degranulation (IC50 < 100 nM), thereby blocking mast cell activation. MrgprX2 antagonist-10 can be used in research on MRGPRX2-related inflammatory and allergic diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
