Search Result

Results for "

β-hexosaminidase release

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (2) Biochemical Assay Reagents (2) Calcium Channel (3) Endogenous Metabolite (1) Fc Receptor (FcR) (2) Glutathione S-transferase (1) Glycosidase (7) Histamine Receptor (1) Interleukin Related (1) Mas-related G-protein-coupled Receptor (MRGPR) (2) Opioid Receptor (2) P2Y Receptor (2) p38 MAPK (2) PKC (1) Reactive Oxygen Species (ROS) (1) TNF Receptor (4)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (12) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Targets Recommended: CRAC Channel

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-113242

5-Nonadecylresorcinol	Glycosidase	Others
5-Nonadecylresorcinol is an alkylresorcinol and has inhibitory effects on the release of *β-hexosaminidase* in vitro .

HY-172458

Z-3578 1 Publications Verification	Mas-related G-protein-coupled Receptor (MRGPR) TNF Receptor	Inflammation/Immunology
Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a K_D value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of *β-hexosaminidase, significantly reduces the release* of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions .

HY-P1793

α-Casein (90-95)	Opioid Receptor Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology Cancer
α-Casein (90-95) is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC₅₀= 0.1 μM. α-Casein (90-95) inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC₅₀ of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) activates G_i-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) can be used in the study of the mechanisms of allergic diseases and prostate cancer .

HY-P991651

MEDI4212	Fc Receptor (FcR)	Inflammation/Immunology
MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcεRI, such as calcium signaling, β-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC₅₀ of 8 nM. MEDI4212 can be used severe asthma research .

HY-N15708

Dichotomine C (R)-(-)-Dichotomine C	Glycosidase TNF Receptor Interleukin Related	Inflammation/Immunology
Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of *β-hexosaminidase* in RBL-2H3 cells with an IC₅₀ of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC₅₀s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions .

HY-N3815

ent-16-Kaurene-3b,15b,18-triol	Others	Inflammation/Immunology
ent-16-Kaurene-3b,15b,18-triol is a ent-kaurene diterpene. ent-16-Kaurene-3b,15b,18-triol has significant antiallergic activity on β-hexosaminidase release induced by Polyginseng antigen .

HY-P1793A

α-Casein (90-95) TFA	Opioid Receptor Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology Cancer
α-Casein (90-95) TFA is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) TFA inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC₅₀= 0.1 μM. α-Casein (90-95) TFA inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC₅₀ of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) TFA activates G_i-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) TFA can be used in the study of the mechanisms of allergic diseases and prostate cancer .

HY-N8426

4'-O-Methylnyasol Ellisinin A	Histamine Receptor	Cancer
4'-O-Methylnyasol is an inhibitor of *β-hexosaminidase. 4'-O-Methylnyasol inhibits β-hexosaminidase* release from rat basophilic leukemia-2H3 cells with an IC₅₀ of 52.67 μM .

HY-N12116

Maceneolignan A	TNF Receptor	Cancer
Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae). Maceneolignan A inhibits the release of *β-hexosaminidase* in RBL-2H3 cells, with an IC₅₀ of 48.4 μM. Maceneolignan A inhibits the release of TNF-α in antigen stimulated RBL-2H3 cells, with an IC₅₀ of 63.7 μM .

HY-N12261

Benastatin B	Glutathione S-transferase Bacterial	Infection Inflammation/Immunology Cancer
Benastatin B is an inhibitor for glutathione S-transferase, that inhibits human pi class GST with an IC₅₀ of 1.10 μg/mL. Benastatin B exhibits board-spectrum antibacterial efficacy, inhibits MRSA with MIC 3.1 μg/mL. Benastatin B exhibits anti-inflammatory efficacy through inhibition of IgE mediated β-hexosaminidase release with an IC₅₀ of 79 μg/mL .

HY-P11163

Eumenitin	Bacterial Glycosidase	Infection
Eumenitin is an antibacterial peptide with strong membrane activity, broad-spectrum antibacterial activity, and almost no hemolytic toxicity. Eumenitin has inhibitory effects on various Gram positive and Gram negative bacteria. Eumenitin can induce the release of *β-hexosaminidase* from rat peritoneal mast cells and RBL-2H3 cells. Eumenitin can be used in the research of infectious conditions .

HY-N16668

(3R,5S)-5'-Methoxyoctahydrocurcumin	Glycosidase	Inflammation/Immunology
(3R,5S)-5'-Methoxyoctahydrocurcumin (Compound 4) is a diarylheptanoidfound in Curcuma comosa. (3R,5S)-5'-Methoxyoctahydrocurcumin exhibits strong antiallergic activity by inhibiting *β-hexosaminidase* release and the degranulation of mast cells. (3R,5S)-5'-Methoxyoctahydrocurcumin can be used for the research of immunology, such as asthma .

HY-116295

MRS2690	P2Y Receptor p38 MAPK Calcium Channel	Cardiovascular Disease
MRS2690 is a selective P2Y14 receptor agonist. MRS2690 inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 induces intracellular calcium mobilization, activates P38 and stimulates [ ³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690can be used for ischemic heart disease .

HY-116295A

MRS2690 disodium	P2Y Receptor p38 MAPK Calcium Channel	Cardiovascular Disease
MRS2690 disodium is a selective P2Y14 receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [ ³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease .

HY-N18182

Mudanpioside E	Glycosidase	Inflammation/Immunology
Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC₅₀ of 40.34 μM against IgE-mediated *β-hexosaminidase* release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases .

HY-181891

XAT-13	Mas-related G-protein-coupled Receptor (MRGPR) Calcium Channel Glycosidase	Inflammation/Immunology
XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and *β-hexosaminidase* release. XAT-13 can be used for the research of pseudo-allergic diseases .

HY-N11725

Phlorofucofuroeckol A	Fc Receptor (FcR)	Inflammation/Immunology
Phlorofucofuroeckol A is a FcεRI inhibitor with low cytotoxicity toward basophilic leukemia cells. Phlorofucofuroeckol A suppresses binding activity between IgE and FcεRI receptor. Phlorofucofuroeckol A inhibits histamine release from basophilic leukemia cells stimulated by IgE/anti-IgE or calcium ionophore A23187 (HY-N6687). Phlorofucofuroeckol A inhibits *β-hexosaminidase* release from basophilic leukemia cells stimulated by IgE/DNP-BSA. Phlorofucofuroeckol A can be used for the research of allergy disease .

HY-149151

Variegatic acid	Endogenous Metabolite PKC Glycosidase TNF Receptor Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Variegatic acid is a secondary metabolite derived from basidiomycete fungi. Variegatic acid is a PKCβ1 inhibitor with an IC₅₀ of 36.2 μM. Variegatic acid inhibits antigen- or calcium ionophore-induced *β-hexosaminidase* release (IC₅₀ values of 10.4 μM and 22.2 μM, respectively) and TNF-α secretion (IC₅₀ values of 16.8 μM and 20.1 μM, respectively). Variegatic acid suppresses the enzymatic activity of calcium-activated PKCβ1 and reduces Fe(III) to Fe(II) in a pH-dependent manner, enabling the generation of hydroxyl radicals (·OH) through reaction with H₂O₂, which facilitates the degradation of lignocellulose. Variegatic acid is useful for studying biological degradation and allergic responses.

Cat. No.	Nombre del producto	Target	Research Area

HY-P1793

α-Casein (90-95)	Opioid Receptor Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology Cancer
α-Casein (90-95) is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC₅₀= 0.1 μM. α-Casein (90-95) inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC₅₀ of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) activates G_i-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) can be used in the study of the mechanisms of allergic diseases and prostate cancer .

HY-P1793A

α-Casein (90-95) TFA	Opioid Receptor Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology Cancer
α-Casein (90-95) TFA is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) TFA inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC₅₀= 0.1 μM. α-Casein (90-95) TFA inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC₅₀ of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) TFA activates G_i-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) TFA can be used in the study of the mechanisms of allergic diseases and prostate cancer .

HY-P11163

Eumenitin	Bacterial Glycosidase	Infection
Eumenitin is an antibacterial peptide with strong membrane activity, broad-spectrum antibacterial activity, and almost no hemolytic toxicity. Eumenitin has inhibitory effects on various Gram positive and Gram negative bacteria. Eumenitin can induce the release of *β-hexosaminidase* from rat peritoneal mast cells and RBL-2H3 cells. Eumenitin can be used in the research of infectious conditions .

Cat. No.	Nombre del producto	Target	Research Area	Image

HY-P991651

MEDI4212	Fc Receptor (FcR)	Inflammation/Immunology
MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcεRI, such as calcium signaling, β-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC₅₀ of 8 nM. MEDI4212 can be used severe asthma research .

5-Nonadecylresorcinol	Agrostidoideae Phenols Polyphenols Plants Triticum aestivum L. Source Classification	Glycosidase
5-Nonadecylresorcinol is an alkylresorcinol and has inhibitory effects on the release of *β-hexosaminidase* in vitro .

Dichotomine C (R)-(-)-Dichotomine C	Alkaloids Stellaria dichotoma L. Plants Caryophyllaceae Indole Alkaloids Source Classification	Glycosidase TNF Receptor Interleukin Related
Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of *β-hexosaminidase* in RBL-2H3 cells with an IC₅₀ of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC₅₀s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions .

ent-16-Kaurene-3b,15b,18-triol	Suregada multiflora (Jussieu) Baillon Terpenoids Diterpenoids Euphorbiaceae Plants Source Classification	Others
ent-16-Kaurene-3b,15b,18-triol is a ent-kaurene diterpene. ent-16-Kaurene-3b,15b,18-triol has significant antiallergic activity on β-hexosaminidase release induced by Polyginseng antigen .

4'-O-Methylnyasol Ellisinin A	Productos naturales Liliaceae Anemarrhena asphodeloides Bunge Plants Source Classification	Histamine Receptor
4'-O-Methylnyasol is an inhibitor of *β-hexosaminidase. 4'-O-Methylnyasol inhibits β-hexosaminidase* release from rat basophilic leukemia-2H3 cells with an IC₅₀ of 52.67 μM .

Maceneolignan A	Monophenols Phenols Myristicaceae Plants Myristica fragrans Houtt. Source Classification	TNF Receptor
Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae). Maceneolignan A inhibits the release of *β-hexosaminidase* in RBL-2H3 cells, with an IC₅₀ of 48.4 μM. Maceneolignan A inhibits the release of TNF-α in antigen stimulated RBL-2H3 cells, with an IC₅₀ of 63.7 μM .

Benastatin B	Microorganisms Phenols Polyphenols Source Classification	Glutathione S-transferase Bacterial
Benastatin B is an inhibitor for glutathione S-transferase, that inhibits human pi class GST with an IC₅₀ of 1.10 μg/mL. Benastatin B exhibits board-spectrum antibacterial efficacy, inhibits MRSA with MIC 3.1 μg/mL. Benastatin B exhibits anti-inflammatory efficacy through inhibition of IgE mediated β-hexosaminidase release with an IC₅₀ of 79 μg/mL .

(3R,5S)-5'-Methoxyoctahydrocurcumin	Structural Classification Phenols Polyphenols Plants Source Classification Curcuma comosa Roxb. Zingiberaceae	Glycosidase
(3R,5S)-5'-Methoxyoctahydrocurcumin (Compound 4) is a diarylheptanoidfound in Curcuma comosa. (3R,5S)-5'-Methoxyoctahydrocurcumin exhibits strong antiallergic activity by inhibiting *β-hexosaminidase* release and the degranulation of mast cells. (3R,5S)-5'-Methoxyoctahydrocurcumin can be used for the research of immunology, such as asthma .

Mudanpioside E	Structural Classification Monophenols Paeonia lactiflora Pall. Phenols Plants Paeoniaceae Source Classification	Glycosidase
Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC₅₀ of 40.34 μM against IgE-mediated *β-hexosaminidase* release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases .

Phlorofucofuroeckol A	Structural Classification Microorganisms Phenols Polyphenols Source Classification	Fc Receptor (FcR)
Phlorofucofuroeckol A is a FcεRI inhibitor with low cytotoxicity toward basophilic leukemia cells. Phlorofucofuroeckol A suppresses binding activity between IgE and FcεRI receptor. Phlorofucofuroeckol A inhibits histamine release from basophilic leukemia cells stimulated by IgE/anti-IgE or calcium ionophore A23187 (HY-N6687). Phlorofucofuroeckol A inhibits *β-hexosaminidase* release from basophilic leukemia cells stimulated by IgE/DNP-BSA. Phlorofucofuroeckol A can be used for the research of allergy disease .

Variegatic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite PKC Glycosidase TNF Receptor Reactive Oxygen Species (ROS)
Variegatic acid is a secondary metabolite derived from basidiomycete fungi. Variegatic acid is a PKCβ1 inhibitor with an IC₅₀ of 36.2 μM. Variegatic acid inhibits antigen- or calcium ionophore-induced *β-hexosaminidase* release (IC₅₀ values of 10.4 μM and 22.2 μM, respectively) and TNF-α secretion (IC₅₀ values of 16.8 μM and 20.1 μM, respectively). Variegatic acid suppresses the enzymatic activity of calcium-activated PKCβ1 and reduces Fe(III) to Fe(II) in a pH-dependent manner, enabling the generation of hydroxyl radicals (·OH) through reaction with H₂O₂, which facilitates the degradation of lignocellulose. Variegatic acid is useful for studying biological degradation and allergic responses.

Consulta en línea

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Saludo			Country or Region *
Nombre del solicitante *			Nombre de la Organizaciòn *
Department *
Direcciòn del E-mail *			Nombre del producto *
Cat. No.			Requested quantity *
Número de teléfono *
Observaciones

Consulta en línea

Inquiry Information

Nombre del producto:
Cat. No.:
Cantidad:
MCE Japan Authorized Agent:

β-hexosaminidase release

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Natural
Products