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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
2-Ketoglutaric acid
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "2-Ketoglutaric acid" in MCE Product Catalog:
7
7 Publications Verification
Cat. No.: HY-W013636
CAS No.: 328-50-7
Synonyms: Alpha-Ketoglutaric acid; 2-Oxoglutaric acid
Category:
Anti-aging Endocrine diseases Endogenous metabolite Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Other Diseases Disease markers Nervous System Disorder Disease Research Fields
Target:
7
7 Publications Verification
Cat. No.: HY-W013636A
CAS No.: 22202-68-2
Synonyms: Alpha-Ketoglutaric acid Sodium
Target:
7
7 Publications Verification
Cat. No.: HY-W013636C
CAS No.: 997-43-3
Synonyms: Alpha-Ketoglutaric acid potassium
1
1 Cited Publications
Research Areas:
MDH1-IN-2 (Compound 7c) is a selective MDH1 inhibitor, with IC50 values of 2.27 and 27.47 μM for MDH1 and MDH2, respectively. MDH1-IN-2 can reduce the generation of ROS by inhibiting the conversion of 2-Ketoglutaric acid (HY-W013636) to α-Hydroxyglutaric acid (HY-113038B) mediated by MDH1, thereby suppressing 2-Ketoglutaric acid (HY-W013636)-induced ferroptosis .
Cat. No.: HY-W013636S
CAS No.: 161096-83-9
Synonyms: Alpha-Ketoglutaric acid-13C5
Cat. No.: HY-W013636S1
CAS No.: 1381759-60-9
Synonyms: Alpha-Ketoglutaric acid-d4
Cat. No.: HY-W013636R
CAS No.: 328-50-7
Synonyms: Alpha-Ketoglutaric acid (Standard); 2-Oxoglutaric acid (Standard)
Cat. No.: HY-W013636S2
CAS No.: 1173021-86-7
Synonyms: Alpha-Ketoglutaric acid-d6
Cat. No.: HY-W013636S3
CAS No.: 108395-15-9
Synonyms: Alpha-Ketoglutaric acid-13C
Cat. No.: HY-W013636S4
CAS No.: 123953-28-6
Synonyms: Alpha-Ketoglutaric acid-13C2
Cat. No.: HY-W013636AR
CAS No.: 22202-68-2
Synonyms: Alpha-Ketoglutaric acid Sodium (Standard)
Cat. No.: HY-W013636AG
CAS No.: 22202-68-2
Synonyms: Alpha-Ketoglutaric acid Sodium (GMP)
Cat. No.: HY-187102
CAS No.: 19866-38-7
Target:
Research Areas:
2-Hydrazinyl-3-methylbutanoic acid is a diamine oxidase (DAO) inhibitor. 2-Hydrazinyl-3-methylbutanoic acid acts as a non-competitive inhibitor of diamine oxidase (with histamine as the substrate), achieving an inhibition rate of up to 76%. This inhibition can be prevented by pre-incubation with 2-Ketoglutaric acid (HY-W013636) to form a non-inhibitory complex. 2-Hydrazinyl-3-methylbutanoic acid also inhibits glutamate decarboxylase and 5-hydroxytryptophan decarboxylase, and exhibits moderate inhibitory activity against monoamine oxidase. 2-Hydrazinyl-3-methylbutanoic acid can be used in studies related to amino acid metabolic enzymes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
