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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
A1R
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "A1R" in MCE Product Catalog:
16
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3 Cited Publications
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SCH442416 is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR), with Kis of 0.048 and 0.5 nM for human and rat A2AR respectively. SCH442416 displays more than 23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A2A receptors in rat and primate brain [1] .
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2 Cited Publications
Cat. No.: HY-N0092S2
CAS No.: 503173-79-3
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2 Cited Publications
Cat. No.: HY-P2259
CAS No.: 1404188-93-7
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Cat. No.: HY-100013A1R
CAS No.: 1609563-71-4
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(1R,2R)-2-PCCA (hydrochloride) (Standard) is the analytical standard of (1R,2R)-2-PCCA (hydrochloride) (HY-100013A1). This product is intended for research and analytical applications. (1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay.
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MIPS521 is a positive allosteric modulator of adenosine A1 receptor (A1AR). MIPS521 also has a lower A1R allosteric affinity (pKB=4.95; KB=11 μM). MIPS521 exhibits pain-relieving effects in vivo through modulation of the increased levels of endogenous adenosine [1] .
Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation .
Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes .
In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice .
Cat. No.: HY-N0092S
CAS No.: 697807-01-5
Cat. No.: HY-113608
CAS No.: 1018830-99-3
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VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain [1].
Cat. No.: HY-N0092S4
Cat. No.: HY-N0092S1
Cat. No.: HY-161418
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1-NBX is a potent and selective A1R ligand. 1-NBX exhibits significantly improved A1R affinity with with a Ki of 2.6 nM and lower affinity for the A2A receptor with a Ki of 164 nM [1].
Cat. No.: HY-179277
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MIPS3526 is a potent and selective A2B adenosine receptor (A2BR) agonist with a pEC50 of 10.17 (EC50 of 58 pM). MIPS3526 shows highly receptor subtype selective versus the A1R, A2AR, and A3R. MIPS3526 ameliorates angiotensin II stimulating effects in both cardiac myocytes and fibroblasts. MIPS3526 can be used for the study of cardiovascular disease including heart failure where cardiac remodeling is a major driver [1].
Cat. No.: HY-153333
CAS No.: 2665804-57-7
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A1/A3 AR antagonist 3 is an A1R/A3R dual antagonist with high affinity at low-micromolar to low-nanomolar. A1/A3 AR antagonist 3 can be used for the research of chronic heart diseases [1].
Cat. No.: HY-163978
CAS No.: 1350113-04-0
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YGZ-331 is a sedative with a calming effect. YGZ-331 is a derivative of the adenosine nucleoside NGBA, which can increase GABA levels. YGZ-331 exerts a sedative-hypnotic effect by activating A1R and A2aR, and inhibiting CaMKII phosphorylation (pCaMKII) levels. YGZ-331 can reduce the spontaneous motor activity of mice [1].
Cat. No.: HY-103169R
CAS No.: 316173-57-6
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SCH442416 (Standard) is the analytical standard of SCH442416. This product is intended for research and analytical applications. SCH442416 is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR), with Kis of 0.048 and 0.5 nM for human and rat A2AR respectively. SCH442416 displays more than 23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A2A receptors in rat and primate brain [1] .
Cat. No.: HY-RS00392
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Adora1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adora1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-CE00091
Synonyms: (1R)-MCPA-Coenzyme A
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(1R)-(Methylenecyclopropyl)acetyl-CoA ((1R)-MCPA-Coenzyme A) is a derivative of Coenzyme A (HY-128851).
Cat. No.: HY-CE01906
Synonyms: 2-Oxo-delta(3)-4,5,5-trimethylcyclopentenylacetyl-coenzyme A
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[(1R)-2,2,3-Trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA (2-Oxo-delta(3)-4,5,5-trimethylcyclopentenylacetyl-coenzyme A) is a coenzyme A derivative [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
