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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
ASIC1
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "ASIC1" in MCE Product Catalog:
7
7 Publications Verification
Cat. No.: HY-P1411
CAS No.: 880107-52-8
Synonyms: PcTx1; Psalmopoeus cambridgei toxin-1
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7
7 Publications Verification
Cat. No.: HY-P1411A
Synonyms: PcTx1 TFA; Psalmopoeus cambridgei toxin-1 TFA
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1
1 Cited Publications
Cat. No.: HY-P1441A
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Cat. No.: HY-164284
CAS No.: 2649762-09-2
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LK-2 is an antagonist for ASIC1a with a Kd of 1.9 μM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 μM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable [1].
Cat. No.: HY-176550
CAS No.: 1787243-08-6
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ASIC1a antagonist-1 (Compound 5b) is an orthosteric noncompetitive Acid sensing ion channels 1a (ASIC1a) antagonist with an IC50 of 27 nM (pH 6.7). ASIC1a antagonist-1 shifts pH dependence of ASIC1a activation and inhibits its maximal evoked response. ASIC1a antagonist-1 completely inhibits long-term potentiation (LTP) induction in CA3-CA1 pathway. ASIC1a antagonist-1 can be used for brain diseases and pathologies research [1].
Cat. No.: HY-P5174
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Cat. No.: HY-RS01089
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ASIC1 Human Pre-designed siRNA Set A contains three designed siRNAs for ASIC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24060
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Asic1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Asic1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits [1].
Cat. No.: HY-RS17600
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Asic1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Asic1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-155017
CAS No.: 60398-23-4
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6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM [1].
Cat. No.: HY-P990338
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Cat. No.: HY-P5172
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Cat. No.: HY-P5899
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Cat. No.: HY-131261
CAS No.: 36039-36-8
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Ibuprofen alcohol, a nonsteroidal antiinflammatory agent (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs) .
Cat. No.: HY-P10977
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Cat. No.: HY-P5780
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Cat. No.: HY-131261R
CAS No.: 36039-36-8
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Ibuprofen alcohol (Standard) is the analytical standard of Ibuprofen alcohol. This product is intended for research and analytical applications. Ibuprofen alcohol, a nonsteroidal antiinflammatory agent (NSAID), exhibits very little activity for acid-sensing ion channels (ASICs) .
Cat. No.: HY-P990339
Synonyms: ORY012
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Cat. No.: HY-W703632
CAS No.: 1794979-83-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
