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Results for "

BAG3

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Inhibitory Antibodies

1

Recombinant Proteins

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-117282
    JG-98
    10+ Cited Publications

    		 HSP Apoptosis Cancer
    JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages [3].
    JG-98
  • HY-170944
    BAG3/HSP70-IN-1

    		HSP Apoptosis Caspase Cancer
    BAG3/HSP70-IN-1 (compound 16) is the first-in-class BAG3 and HSP70 dual inhibitor. BAG3/HSP70-IN-1 binds to BAG3 full-length, BAG3-BD, and HSP70 proteins with Kds of 33.10 μM, 27.90 μM, and 33.80 μM, respectively. BAG3/HSP70-IN-1 inhibits HeLa cells with an IC50 of 49.46 μM. BAG3/HSP70-IN-1 induces apoptosis by activating caspase 3 and caspase 9 levels in HeLa cells. BAG3/HSP70-IN-1 elevates p21 levels while reduces FOXM1 expression in HeLa cells. BAG3/HSP70-IN-1 decreases ATPase activity .
    BAG3/HSP70-IN-1
  • HY-156278
    FB49

    		Apoptosis Autophagy Cancer
    FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the Ki of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells .
    FB49
  • HY-RS01344
    BAG3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    BAG3 Human Pre-designed siRNA Set A contains three designed siRNAs for BAG3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BAG3 Human Pre-designed siRNA Set A
    BAG3 Human Pre-designed siRNA Set A
  • HY-RS23782
    Bag3 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Bag3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bag3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Bag3 Rat Pre-designed siRNA Set A
    Bag3 Rat Pre-designed siRNA Set A
  • HY-RS17327
    Bag3 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Bag3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bag3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Bag3 Mouse Pre-designed siRNA Set A
    Bag3 Mouse Pre-designed siRNA Set A
  • HY-P992379
    IB001

    BAG3-H2L4

    		 Bcl-2 Family Cancer
    IB001 is a humanized anti-BAG3 antibody that inhibits BAG3, with a KD value of 14.4 nM for human BAG3. IB001 blocks BAG3-dependent monocyte/macrophage activation, interferes with the interaction between BAG3 and IFITM-2, and disrupts tumor microenvironment signaling pathways. IB001 inhibits tumor growth, reduces α-SMA-positive fibroblasts, and blocks BAG3-dependent IL-6 release. IB001 accumulates in a time-dependent manner in pancreatic ductal adenocarcinoma tumors. IB001 can be used for research related to pancreatic ductal adenocarcinoma .
    IB001
  • HY-180948
    PZ-11

    		Drug Derivative Apoptosis Bcl-2 Family Caspase IAP Cancer
    PZ-11 is a derivative of thiazolidinedione with anti-tumor activity. PZ-11 can induce cancer cells apoptosis by downregulating anti-apoptotic gene AIFM1, BAG3 and BIRC3 and regulating pro-apoptotic gene BAD, HRK, CASP10 and CASP10. PZ-11 can be used for research of breast cancer .
    PZ-11

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