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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
BDK
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "BDK" in MCE Product Catalog:
9
9 Cited Publications
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BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC) . BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM .
Cat. No.: HY-159648
CAS No.: 2936625-34-0
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PF-07328948 is an orally effective BDK (branch chain ketoacid dehydrogenase kinase) inhibitor, with IC50 of 110 nM. PF-07328948 acts as a BCKDH (branch chain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branch chain amino acid) catabolism. PF-07328948 improves metabolic and heart failure end points in rats .
Category:
Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields
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Cat. No.: HY-155157
Purity: 98.66%
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Cat. No.: HY-RS01411
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BCKDK Human Pre-designed siRNA Set A contains three designed siRNAs for BCKDK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-155156
Purity: 99.46%
Category:
Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields
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Cat. No.: HY-W110242
CAS No.: 41998-38-3
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(S)-CPP is an allosteric BDK inhibitor. (S)-CPP can be used in the research of type 2 diabetes .
Cat. No.: HY-W110242A
CAS No.: 194979-70-9
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(S)-CPP sodium serves as an inhibitor of the branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, the inhibition of BDK by (S)-CPP (with an IC50 of 6.3 μM) results in the activation of the complex and a notable decrease in plasma levels of leucine/isoleucine and valine in wild-type mice.
Cat. No.: HY-RS19988
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Bckdk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bckdk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07411
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KNG1 Human Pre-designed siRNA Set A contains three designed siRNAs for KNG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-169334
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BDK-IN-1 (compound (-)-43) is a BDK inhibitor with the IC50 of 0.23 μM and the max inhibition of 90%. BDK-IN-1 decreases the level of phospho-E1 and can be used for study of cardiometabolic diseases .
Cat. No.: HY-RS26492
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Bckdk Rat Pre-designed siRNA Set A contains three designed siRNAs for Bckdk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P810471
Synonyms: BCKDK, Branched Chain Keto Acid Dehydrogenase Kinase, [3-Methyl-2-Oxobutanoate Dehydrogenase [Lipoamide]] Kinase, Mitochondrial, Branched-Chain Alpha-Ketoacid Dehydrogenase Kinase, BCKDH Kinase, EC 2.7.11.4, BCKDHKIN, BDK, 3-Methyl-2-Oxobutanoate Dehydrogenase [Lipoamide] Kinase, Mitochondrial, Branched Chain Alpha-Ketoacid Dehydrogenase Kinase, Branched Chain Ketoacid Dehydrogenase Kinase, BCKD-Kinase, EC 2.7.11.1, EC 2.7.11, BCKDKD
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
