86 Results for "

CD33

" in MedChemExpress (MCE) Product Catalog:
Products (86)

86 Results for "CD33" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-109539
CAS No.: 220578-59-6
Purity:  98.0%
Research Areas:  

Cancer

Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) consisting of a humanized immunoglobulin (IgG4) antibody directed against CD33 that is conjugated to the cytotoxic agent Calicheamicin (HY-19609). The antibody portion is Gemtuzumab (HY-P99971), and the drug-linker conjugate for ADC is N-Ac-γ-Calicheamicin-AcBut-NHS ester (HY-103688). Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia (AML) .
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1
1 Cited Publications
Cat. No.: HY-P70742
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3
Species:  
Source:  
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Cat. No.: HY-P99329
CAS No.: 1436390-63-4
Synonyms: Anti-Human CD33 Recombinant Antibody

Research Areas:  

Cancer

Vadastuximab (Anti-Human CD33 Recombinant Antibody) is a humanized monoclonal antibody targeting CD33. Vadastuximab can be used to synthesize an ADC compound, Vadastuximab talirine .
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Cat. No.: HY-P99971
CAS No.: 2924764-21-4

Research Areas:  

Cancer

Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-171792
Synonyms: ORM-6151
Research Areas:  

Cancer

BMS-986497 (ORM-6151) is a CD33-targeting antibody-conjugated GSPT1 degrader. BMS-986497 delivers the GSPT1 degrader SMol006 to CD33-expressing cells and induces GSPT1 protein degradation. BMS-986497 shows potential for research on acute myeloid leukemia (AML) .
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Cat. No.: HY-144399
CAS No.: 2762547-05-5
Purity:  99.55%
Research Areas:  

Neurological Disease

CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity. CD33 splicing modulator 1 increases exon 2 skipping in cellular mRNA pools. CD33 splicing modulator 1 has the potential for the research of neurodegenerative disease including Alzheimer's disease .
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Cat. No.: HY-P99910
CAS No.: 1679391-73-1
Synonyms: AMG-330

Research Areas:  

Cancer

Eluvixtamab (AMG-330) is a bispecific T-cell engager. Eluvixtamab binds to CD33 and CD3 on T cells, thereby promoting T cell-mediated cytotoxicity against CD33+ cells. Eluvixtamab can be used in the research of tumors such as relapsed/refractory acute myeloid leukemia .
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Cat. No.: HY-P9983
CAS No.: 166089-32-3
Synonyms: SGN-33; HuM-195; GLK-33 Antibody
Lintuzumab (HUM-195) is an anti-CD33 humanized monoclonal antibody. Lintuzumab reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells. Lintuzumab promotes tumor cell killing through antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) activities against MDR and MDR+ AML cell lines and primary AML patient samples. Lintuzumab enhances survival and reduces tumor burden in mice .
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Cat. No.: HY-P99958
CAS No.: 2243775-32-6
Synonyms: AMV-564; TandAb T564

Research Areas:  

Cancer

Vixtimotamab (AMV-564; TandAb T564) is a bispecific tetravalent tandem diabody (TandAb) that targets human CD33 and human CD3 antigens. Vixtimotamab can be used for the research of acute myeloid leukemia (AML) .
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Cat. No.: HY-P99912
CAS No.: 2250261-27-7
Synonyms: AMG-673

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Emerfetamab is an anti-CD3E/CD33 monoclonal antibody .
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Cat. No.: HY-P991517
BI-836858 is a fully human anti-CD33 monoclonal antibody. BI-836858 reduces CD33+ cells via antibody-dependent cellular cytotoxicity (ADCC), blocks downstream signaling of S100A9/CD33, decreases the secretion of immunosuppressive cytokines and reactive oxygen species-induced genomic instability, and restores bone marrow hematopoietic function. BI-836858 is applicable to the research of myelodysplastic syndrome (MDS) and AML .
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Cat. No.: HY-P990605
Synonyms: IMGN-779 antibody

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Anti-CD33 Antibody (IMGN-779 antibody) is a CHO-expressed humanized antibody targeting Siglec-3/CD33. Anti-CD33 Antibody carries a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.6 kDa. The isotype control for Anti-CD33 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P990903
CAS No.: 2577961-36-3
Synonyms: YMS-5A

Target:  

CD3

Research Areas:  

Inflammation/Immunology

HY-P990903 is an CD3E/CD33-targeting [H-γ1 _ L-κ-scFv heavy -κ]-dimer type bispecific antibody .
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Cat. No.: HY-144399A
CAS No.: 2762547-06-6
Research Areas:  

Neurological Disease

CD33 splicing modulator 1 (Compound 1) hydrochloride is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid cell surface receptor known to regulate microglial activity. CD33 splicing modulator 1 hydrochloride increases exon 2 skipping in the cellular mRNA pool and can be used to study neurodegenerative diseases including Alzheimer's disease .
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Cat. No.: HY-P991364
CAS No.: 2865844-59-1
Synonyms: PYX-106; BSI-060T

Research Areas:  

Cancer

Aldastotug (PYX-106; BSI-060T) is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3. Aldastotug reverses Siglec-15-mediated immunosuppression and enhances T-cell proliferation. Aldastotug induces significantly increased levels of IFNγ and TNFα in T cells. Aldastotug can be used in cancer immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P990633
Synonyms: 5G-12

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

NC-318 (5G-12) is a human-derived antibody expressed by CHO, targeting Siglec-15/CD33L3. NC-318 (5G-12) has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 146.98 kDa. The isotype control for NC-318 (5G-12) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-RS02235
Research Areas:  

Others

CD33 Human Pre-designed siRNA Set A contains three designed siRNAs for CD33 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS17093
Research Areas:  

Others

Cd33 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd33 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23537
Research Areas:  

Others

Cd33 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd33 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-160649
CAS No.: 1599439-52-7
Research Areas:  

Cancer

MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo .
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