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Results for "

CIDEA

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

3

Natural
Products

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N9933
    Tauro-β-muricholic acid
    4 Publications Verification

    TβMCA

    		 FXR Apoptosis Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Tauro-β-muricholic acid (TβMCA) is an orally active trihydroxylated bile acid and a competitive, reversible FXR antagonist (IC50=40 μM). Tauro-β-muricholic acid inhibits bile acid-induced hepatocyte apoptosis by maintaining mitochondrial membrane potential, while simultaneously inhibiting intestinal FXR signaling, affecting bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity. Accumulation of tauro-β-muricholic acid disrupts metabolic homeostasis, promoting cancer stem cell proliferation and tumor progression. The mechanisms of tauro-β-muricholic acid involve two aspects: first, inhibiting the translocation of the pro-apoptotic protein Bax to mitochondria and maintaining mitochondrial membrane potential (MMP); and second, blocking the FXR signaling pathway to regulate bile acid metabolism, reduce serum ceramide production, and downregulate the hepatic SREBP1C/CIDEA pathway. Tauro-β-muricholic acid possesses anti-hepatocyte apoptosis, bile acid homeostasis regulation, and liver fat accumulation reduction properties, and also functions as a biomarker, making it useful in the study of diseases such as bile acid metabolism disorders, non-alcoholic fatty liver disease, colorectal cancer, and liver fibrosis .
    Tauro-β-muricholic acid
  • HY-Y0598
    trans-Chalcone
    2 Publications Verification

    Benzylideneacetophenone

    		 Fatty Acid Synthase (FASN) Apoptosis Fungal Inflammation/Immunology Cancer
    trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity .
    trans-Chalcone
  • HY-RS02711
    CIDEA Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CIDEA Human Pre-designed siRNA Set A contains three designed siRNAs for CIDEA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CIDEA Human Pre-designed siRNA Set A
    CIDEA Human Pre-designed siRNA Set A
  • HY-RS25910
    Cidea Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cidea Rat Pre-designed siRNA Set A contains three designed siRNAs for Cidea gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cidea Rat Pre-designed siRNA Set A
    Cidea Rat Pre-designed siRNA Set A
  • HY-RS19419
    Cidea Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cidea Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cidea gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cidea Mouse Pre-designed siRNA Set A
    Cidea Mouse Pre-designed siRNA Set A
  • HY-183096
    AM31

    		PGC-1α Metabolic Disease
    AM31 is a PGC-1α1 stabilizer. AM31 enhances the protein stability of PGC-1α1, promotes protein accumulation and target gene activation. AM31 induces the expression of Ucp1 and Cidea in brown adipocytes. AM31 increases the levels of basal mitochondrial respiration and uncoupled respiration in brown adipocytes. AM31 can be used for the research of obesity and related metabolic disorders .
    AM31
  • HY-Y0598R
    trans-Chalcone (Standard)

    		Fatty Acid Synthase (FASN) Reference Standards Apoptosis Fungal Inflammation/Immunology Cancer
    trans-Chalcone (Standard) is the analytical standard of trans-Chalcone (HY-Y0598). This product is intended for research and analytical applications. trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity .
    trans-Chalcone (Standard)
  • HY-183095
    AM79

    		Metabolic Disease
    AM79 is a PGC-1α1 stabilizer. AM79 promotes the accumulation of endogenous PGC-1α1 protein, thereby activating its target genes. AM79 increases uncoupled mitochondrial respiration in brown adipocytes. AM79 induces the expression of Ucp1 and Cidea in brown adipocytes. AM79 can be used for the research of obesity and related metabolic disorders .
    AM79
  • HY-183094
    AM73

    		PGC-1α Metabolic Disease
    AM73 is a PGC-1α1 stabilizer. AM73 increases the expression levels of Ucp1 and Cidea in brown adipocytes, and enhances basal mitochondrial respiration and uncoupled respiration. AM73 regulates hypoxia, brown adipocyte differentiation, carbohydrate metabolism and insulin signaling pathways in brown adipocytes. AM73 alters the thermogenic process of white adipocytes. AM73 is applicable to the research of obesity and related metabolic disorders .
    AM73

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