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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
CLOCK
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "CLOCK" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity .
2
2 Cited Publications
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(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function .
2
2 Cited Publications
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KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues .
2
2 Cited Publications
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KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity .
1
1 Cited Publications
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CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms .
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Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].
Cat. No.: HY-W011425
CAS No.: 6419-19-8
Synonyms: Nitrilotris(methylenephosphonic acid)
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NTPO (Nitrilotris methylenephosphonic acid) is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO are abrogated by base excision repair (BER) but not nucleotide excision repair (NER) .
Cat. No.: HY-RS17250
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Clock Mouse Pre-designed siRNA Set A contains three designed siRNAs for Clock gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-134193
CAS No.: 396721-89-4
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KL101, a selective cryptochrome 1 (CRY1) stabilizer, is a circadian clock modulator. KL101 can stabilize the CRY1 protein and regulate its interaction with the core feedback loop of the biological clock, thereby modulating the circadian rhythm cycle of mammals .
Cat. No.: HY-RS02828
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CLOCK Human Pre-designed siRNA Set A contains three designed siRNAs for CLOCK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W011425A
CAS No.: 7611-50-9
Synonyms: Nitrilotris(methylenephosphonic acid), trisodium salt
Cat. No.: HY-RS23704
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Clock Rat Pre-designed siRNA Set A contains three designed siRNAs for Clock gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184895
Target:
Cryptochrome REV-ERB Nuclear Hormone Receptor 4A/NR4A FABP PARP Fatty Acid Synthase (FASN) Wnt β-catenin Hormone-Sensitive Lipase (HSL) PGC-1α ROR GLUT
Research Areas:
CM002 is a circadian clock activator. CM002 inhibits the lineage commitment and terminal differentiation of preadipocytes by activating the circadian clock, thereby blocking the adipogenesis process driven by Wnt signaling-mediated transcriptional induction. CM002 attenuates lipid storage in a clock-dependent manner via inhibition of the lipogenic program in mature adipocytes. CM002 enhances circadian clock output across various adipose depots in both lean and obese mice through BMAL1/CLOCK-dependent metabolic reprogramming, inhibits adipocyte development and hypertrophy, and improves insulin sensitivity. CM002 can be used in research on obesity and type 2 diabetes .
Cat. No.: HY-W928636
CAS No.: 445012-77-1
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5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.
Cat. No.: HY-145149S
Cat. No.: HY-P702668
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1A1; casein kinase 1, alpha 1; casein kinase I isoform alpha; CK1; CK1a; CK1alpha; CKIa; CKIalpha; CLOCK regulator kinase; CKI-alpha; down-regulated in lung cancer; HLCDGP1; PRO2975
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
