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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
CUL3
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "CUL3" in MCE Product Catalog:
1
Target:
Research Areas:
VVD-130037 (BAY-3605349) is a covalent molecular glue and allosteric NRF2 degrader. VVD-130037 covalently binds to KEAP1 and allosterically enhances the affinity of KEAP1-CUL3, promotes the formation of the active KEAP1-CUL3 E3 ligase complex, and thereby enhances the ubiquitination and degradation of NRF2. VVD-130037 exhibits KEAP1 target-binding activity both in in vitro systems and mouse models, and it can be used in research related to NRF2-dependent cancers, solid tumors harboring KEAP1 nonsense mutations and frameshift mutations, as well as advanced solid tumors [3] .
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WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2 .
Cat. No.: HY-124834
CAS No.: 75483-04-4
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Research Areas:
Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis.
Cat. No.: HY-RS03361
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CUL3 Human Pre-designed siRNA Set A contains three designed siRNAs for CUL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18472
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Cul3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cul3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24953
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Cul3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cul3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-139620
CAS No.: 2762181-19-9
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MS83 is a selective degrader of BRD4/BRD3 belonging to the PROTAC class. MS83 hijacks the KEAP1-dependent CUL3 ligase complex by binding to KEAP1 and forming a ternary complex with BRD4/BRD3. MS83 induces polyubiquitination and degradation of BRD4/BRD3 in a concentration-, time- and ubiquitin-proteasome system-dependent manner. MS83 inhibits c-MYC protein levels and suppresses the proliferation of triple-negative breast cancer cells .
Cat. No.: HY-169766
CAS No.: 3034876-85-9
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VVD 065 is an orally active KEAP1-dependent NRF2 molecular glue degrader with a KEAP1 KD of 65 nM. VVD 065 covalently engages KEAP1 at Cys151, allosterically stabilizes KEAP1-CUL3 complex formation and enhances NRF2 polyubiquitination and proteasomal degradation. VVD 065 can be used for the research of esophageal squamous cell carcinoma, lung cancer, head-and-neck cancer, uterine cancers [3].
Cat. No.: HY-172562
CAS No.: 3093583-69-5
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BTR2004 is a potent and selective BET family (BRD2/3/4) PROTAC degrader, with EC50 values of 46, 87, and 777 nM, respectively. By bridging BET family proteins and the CUL3-KLHL20 E3 ubiquitin ligase, BTR2004 forms a ternary complex in the nucleus, thereby mediating the degradation of target proteins via the ubiquitin-proteasome system. BTR2004 can be used in research related to prostate cancer, breast cancer, colorectal cancer, osteosarcoma, and hepatocellular carcinoma .
Cat. No.: HY-178043
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Research Areas:
BTR2038 is a BTR2000-based heterobifunctional PROTAC that induces the degradation of BRD9 by recruiting the CUL3 KLHL20 E3 ubiquitin ligase. BTR2038 consists of a BRD9 bromodomain ligand derived from a BI-7273 analog, a linker, and the macrocyclic KLHL20 ligand BTR2000. BTR2038 is applicable for research related to KLHL20-recruited targeted protein degradation and BRD9 modulation .
Cat. No.: HY-126075
CAS No.: 2247543-65-1
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Research Areas:
WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2 .
Cat. No.: HY-P703245
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CUL3; Uncharacterized Protein CUL3; CULlin 3; KIAA0617; CULlin-3; NEDAUS; CUL-3; PHA2E; RBX1; E3 Ubiquitin-Protein Ligase RBX1; Ring-Box 1; RING Finger Protein 75; RNF75; RING-Box Protein 1; ROC1; Ring-Box 1, E3 Ubiquitin Protein Ligase; Regulator Of CULl
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
