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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
Cdc37
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "Cdc37" in MCE Product Catalog:
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Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC50 of 140 nM.
Synonyms: FW-04-806
Art. -Nr.: HY-RS02297
Target:
Forschungsgebiete:
CDC37 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC37 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS17502
Target:
Forschungsgebiete:
Cdc37 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdc37 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS23959
Target:
Forschungsgebiete:
Cdc37 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdc37 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-147125
CAS. Nr.: 2640292-37-9
DDO-6600 is a covalent Hsp90 inhibitor. DDO-6600 disrupts the interaction between Hsp90 and its co-chaperone protein Cdc37, thereby inducing the degradation of kinase client proteins (such as AKT, CDK4, c-Raf). DDO-6600 has inhibitory activity against various cancer cells. DDO-6600 inhibits the migration and invasion of HCT-116 cells, and induces cell cycle arrest and apoptosis. DDO-6600 significantly inhibits tumor growth in the HCT-116 xenograft tumor model. DDO-6600 can be used for research on colorectal cancer .
Art. -Nr.: HY-174347
CAS. Nr.: 2758818-41-4
Target:
Forschungsgebiete:
Hsp90-Cdc37-IN-4, a Celastrol (HY-13067) derivative, inhibits the Hsp90-Cdc37 protein-protein interaction (PPI). Hsp90-Cdc37-IN-4 selectively inhibits casein kinase 2 (CK2), reducing phosphorylation of its substrate Cdc37 at Serine 13. Hsp90-Cdc37-IN-4 induces G0/G1 cell cycle arrest and triggers apoptosis via the mitochondrial pathway. Hsp90-Cdc37-IN-4 demonstrates potent anti-breast cancer activity .
Art. -Nr.: HY-130624
CAS. Nr.: 2413849-81-5
Hsp90-Cdc37-IN-2 (Compound 41) is an inhibitor for the interaction between heat shock protein 90 (Hsp90) and cyclin 37 (Cdc37). Hsp90-Cdc37-IN-2 inhibits the proliferation of cancer cell A549, MCF-7, HOS and HepG2 with IC50 of 0.41-0.94 μM. Hsp90-Cdc37-IN-2 decreases the mitochondrial membrane potential, induces apoptosis, and arrest cell cycle at G0/G1 phase in A549 .
Art. -Nr.: HY-111414R
CAS. Nr.: 2227303-22-0
Target:
Forschungsgebiete:
Hsp90-Cdc37-IN-1 (Standard) is the analytical standard of Hsp90-Cdc37-IN-1 (HY-111414). This product is intended for research and analytical applications. Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC50 of 140 nM.
Art. -Nr.: HY-P75363
Reinheit: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Cdc37; Cdc37 Cell Division Cycle 37 Homolog; Cell Division Cycle 37, HSP90 Cochaperone; P50Cdc37; Hsp90 Co-Chaperone Cdc37; Cdc37 Cell Division Cycle 37 Homolog (S. Cerevisiae); Hsp90 Chaperone Protein Kinase-Targeting Subunit; Cell Division Cycle 37 Homo
Species:
Mouse
Source:
Sf9 insect cells
Art. -Nr.: HY-P75364
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cdc37; Cdc37 Cell Division Cycle 37 Homolog; Cell Division Cycle 37, HSP90 Cochaperone; P50Cdc37; Hsp90 Co-Chaperone Cdc37; Cdc37 Cell Division Cycle 37 Homolog (S. Cerevisiae); Hsp90 Chaperone Protein Kinase-Targeting Subunit; Cell Division Cycle 37 Homo
Species:
Human
Source:
Sf9 insect cells
Art. -Nr.: HY-P75362
Reinheit: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Cdc37; Cdc37 Cell Division Cycle 37 Homolog; Cell Division Cycle 37, HSP90 Cochaperone; P50Cdc37; Hsp90 Co-Chaperone Cdc37; Cdc37 Cell Division Cycle 37 Homolog (S. Cerevisiae); Hsp90 Chaperone Protein Kinase-Targeting Subunit; Cell Division Cycle 37 Homo
Species:
Mouse
Source:
Sf9 insect cells
Art. -Nr.: HY-19796R
CAS. Nr.: 246529-22-6
Synonyms: Aramchol (Standard); C20-FABAC (Standard)
Forschungsgebiete:
Cucurbitacin D (Standard) is the analytical standard of Cucurbitacin D. This product is intended for research and analytical applications. Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .
Target:
Art. -Nr.: HY-RS02298
Target:
Forschungsgebiete:
CDC37L1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC37L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
