Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
Circulating forms
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "Circulating forms" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: N-Acetylcysteine ethyl ester; NACET
Target:
Research Areas:
N-Acetyl-L-cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant .
12
12 Cited Publications
Synonyms: 5-Methyl THF; 5-MTHF
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
1
1 Cited Publications
Synonyms: CLPM hydrochloride; SR 26334 hydrochloride
Target:
Research Areas:
Clopidogrel carboxylic acid (CLPM) hydrochloride is an inactive metabolite of the widely used antiplatelet medication clopidogrel, which serves as a reference standard for quantitative analysis of clopidogrel metabolism. Clopidogrel carboxylic acid hydrochloride has been shown to represent approximately 85% of circulating clopidogrel, hydrolyzed from the active form by esterases. Clopidogrel carboxylic acid hydrochloride plays a crucial role in assessing the pharmacokinetics and bioavailability of clopidogrel in various clinical and research settings.
1
1 Cited Publications
Cat. No.: HY-150254A
Purity: 99.91%
Target:
Research Areas:
SLB1122168 formic is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 formic inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC50 of 94 nM. SLB1122168 formic induces lymphopenia in circulating lymphocytes in mice and rats .
Cat. No.: HY-P1236
CAS No.: 88898-17-3
Synonyms: Atrial natriuretic factor (1-28) (rat, mouse)
Target:
Research Areas:
Synonyms: Ac-6-FP
Target:
Research Areas:
Acetyl-6-formylpterin (Ac-6-FP) is a hapten that stabilizes MR1 on antigen-presenting cells, forming an MR1:A6FP complex that fails to activate MAIT cell TCR, thereby acting as a competitive inhibitor of MAIT cell activation. Acetyl-6-formylpterin exacerbates house dust mite-induced airway hyperresponsiveness and elevates circulating IgE levels. Acetyl-6-formylpterin reduces systemic MAIT cell activity and decreases the frequency of IL-17A + and IFNγ + MAIT cells in the spleen. Acetyl-6-formylpterin is useful for the study of allergic asthma .
Cat. No.: HY-P1236A
Synonyms: Atrial natriuretic factor (1-28) (rat, mouse) TFA
Target:
Research Areas:
Synonyms: PEG-L-asparaginase; Pegasparaginase
Target:
Research Areas:
Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) through asparagine hydrolysis and activation of the integrated stress response (ISR) pathway .
Cat. No.: HY-113046S1
CAS No.: 212248-92-5
Synonyms: 5-Methyl THF-13C6; 5-MTHF-13C6
Cat. No.: HY-P1573
CAS No.: 123337-89-3
Synonyms: BNP-45, rat
Research Areas:
Cat. No.: HY-19771
CAS No.: 1819986-22-5
Synonyms: GSK294; amyloid P-IN-1
Target:
Research Areas:
GSK3039294 is an orally active pro-drug of Miridesap (HY-101861), a circulating serum amyloid P component depleter. GSK3039294 undergoes hydrolysis to form miridesap via a monoester intermediate. GSK3039294 can be used for the research of systemic amyloidosis .
Cat. No.: HY-W440831
DSPE-PEG1000-azide is a phospholipid with covalently attached polydisperse PEG. This polymer is commonly used for the preparation of long circulating liposomes. The azide moiety is reactive with alkyne to form a stable triazole bond.
Cat. No.: HY-P1573A
Synonyms: BNP-45, rat TFA
Research Areas:
Cat. No.: HY-174650
Target:
Research Areas:
Human IGFBP3 mRNA encodes the human insulin like growth factor binding protein 3 (IGFBP3) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP3 can form a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.
Cat. No.: HY-174649
Target:
Research Areas:
Human IGFBP4 mRNA encodes the human insulin like growth factor binding protein 4 (IGFBP4) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP4 can bind both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
Cat. No.: HY-185373
Synonyms: Liposomal paclitaxel
Target:
Research Areas:
Paclitaxel liposome (Liposomal paclitaxel) is a liposome-encapsulated form of Paclitaxel (HY-B0015). Paclitaxel is a natural antitumor agent that stabilizes tubulin polymerization. Paclitaxel liposome exhibits reduced acute toxicity, prolonged circulating half-life of paclitaxel, and enhanced accumulation at tumor sites. Paclitaxel liposome can be used in cancer-related research .
Cat. No.: HY-187855
CAS No.: 17364-19-1
Synonyms: 18:0-LPC
Target:
Research Areas:
1-Stearoyl-lysophosphatidylcholine (18:0-LPC) is a lysophosphatidylcholine generated by iPLA2β-mediated hydrolysis of phosphatidylcholine and present in circulating LDL; under different hydration conditions, it can form a bilayer gel phase, bilayer liquid crystalline phase, or micellar phase, and serves as a key metabolic node in the JSRV-induced OPA protein-metabolite network. 1-Stearoyl-lysophosphatidylcholine can be used in research on nonalcoholic steatohepatitis and ovine pulmonary adenocarcinoma .
Cat. No.: HY-113046S2
CAS No.: 461426-39-1
Synonyms: 5-Methyl THF-d4; 5-MTHF-d4
Cat. No.: HY-L182
417 compounds
Fatty acids (FAs) are the main components of lipids. The synthesis of fatty acids mainly involves the Triglyceride (TG) cycle and De Novo Lipogenesis (DNL). Fatty acids which exist widely in organisms are components of cell membranes and play an indispensable role in cell signaling. In addition, FFAs can be taken up from circulating plasma by all mitochondria-containing cells, and they are metabolized by β-oxidation and the citric acid cycle to release large amounts of energy in the form of ATP. Abnormal fatty acid metabolism is associated with the occurrence and development of cardiovascular diseases, diabetes, fatty liver, hyperthyroidism, and other diseases.
MCE offers a unique collection of fatty acid compounds. Fatty Acids Compound Library is an important tool for the study of energy metabolism and drug development of metabolism-related diseases.
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
