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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
Class IB
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "Class IB" in MCE Product Catalog:
9
9 Cited Publications
Synonyms: IB-MECA; CF-101
Target:
Research Areas:
Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19 .
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Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
Cat. No.: HY-A0236
CAS No.: 37640-71-4
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Aprindine is an Ib-class anti-arrhythmic agent. Aprindine mainly exerts its effect by blocking sodium channels (INa), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine can also regulate intracellular calcium ion concentration by inhibiting Na +/Ca 2+ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .
Cat. No.: HY-A0236A
CAS No.: 33237-74-0
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Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (INa), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na +/Ca 2+ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .
Cat. No.: HY-106718
CAS No.: 79784-22-8
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Barucainide is an Ib-class anti-arrhythmic agent (moderately blocking sodium channel). Barucainide exhibits concentration-dependent inhibitory effects on the maximum upstroke velocity (Vmax) of Purkinje fibers and ventricular muscle in dogs. Barucainide significantly shortens the action potential duration (APD). Barucainide significantly inhibits the pacemaker activity frequency of atrial tissue in rabbits and the enhanced automaticity of Purkinje fibers under normal resting potential in response to isoproterenol. Barucainide cannot inhibit the abnormal automaticity emission frequency of canine Purkinje fibers induced by barium. Barucainide can be used for research on arrhythmias .
Cat. No.: HY-A0093S
CAS No.: 1329835-60-0
Synonyms: KOE-1173-d6 hydrochloride
Cat. No.: HY-161239A
CAS No.: 220858-11-7
Target:
IB-96212 (compound 5) is a member of oligomycin class which can be extracted ftom the marine Micromonospora sp. L-25-ES25-008 ref. IB-96212 is an antitumor antibiotic against P-388, it also exhibits antimicrobial activity against Micrococcus luteus .
Cat. No.: HY-A0093S1
Synonyms: KOE-1173-d3 hydrochloride
Cat. No.: HY-W710915
Target:
Research Areas:
Mexiletine (hydrochloride) (Standard) is the analytical standard of Mexiletine (hydrochloride). This product is intended for research and analytical applications. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
Cat. No.: HY-P810464
Synonyms: HLA-G, Major HistocompatIBility Complex, Class I, G, HLA Class I HistocompatIBility Antigen, Alpha Chain G, HLA-G HistocompatIBility Antigen, Class I, G, MHC Class I Antigen G, B2 Microglobulin, HLA G Antigen, Mutant MHC Class IB Antigen, Mutant MHC Class I Antigen, MHC Class IB Antigen, MHC Class I Protein, HLA-6.0, MHC-G, HLAG
Cat. No.: HY-P77758
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: HLA-E; NonClassical MHC Class I Antigen; Major HistocompatIBility Complex, Class I, E; MHC Class I Antigen; HLA Class I HistocompatIBility Antigen, Alpha Chain E; Leucocyte Antigen; MHC Class I Antigen E; HLA-E Protein; MHC Class IB Antigen; MHC Antigen;
Cat. No.: HY-P77760
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: HLA-E; NonClassical MHC Class I Antigen; Major HistocompatIBility Complex, Class I, E; MHC Class I Antigen; HLA Class I HistocompatIBility Antigen, Alpha Chain E; Leucocyte Antigen; MHC Class I Antigen E; HLA-E Protein; MHC Class IB Antigen; MHC Antigen;
Cat. No.: HY-P702839
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: HLA-E; NonClassical MHC Class I Antigen; Major HistocompatIBility Complex, Class I, E; MHC Class I Antigen; HLA Class I HistocompatIBility Antigen, Alpha Chain E; Leucocyte Antigen; MHC Class I Antigen E; HLA-E Protein; MHC Class IB Antigen; MHC Antigen;
Cat. No.: HY-P77761
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: HLA-E; NonClassical MHC Class I Antigen; Major HistocompatIBility Complex, Class I, E; MHC Class I Antigen; HLA Class I HistocompatIBility Antigen, Alpha Chain E; Leucocyte Antigen; MHC Class I Antigen E; HLA-E Protein; MHC Class IB Antigen; MHC Antigen;
Cat. No.: HY-P705386
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HLA-E; NonClassical MHC Class I Antigen; Major HistocompatIBility Complex, Class I, E; MHC Class I Antigen; HLA Class I HistocompatIBility Antigen, Alpha Chain E; Leucocyte Antigen; MHC Class I Antigen E; HLA-E Protein; MHC Class IB Antigen; MHC Antigen;
Cat. No.: HY-P76485
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAN1A2; Alpha-1,2-Mannosidase IB; Mannosidase Alpha Class 1A Member 2; Mannosidase, Alpha, Class 1A, Member 2; MAN1B; Alpha-1,2-Mannosidase; Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase IB; Alpha1,2-Mannosidase; Processing Alpha-1,2-Mannosidase IB
Cat. No.: HY-P705387
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HLA-E; NonClassical MHC Class I Antigen; Major HistocompatIBility Complex, Class I, E; MHC Class I Antigen; HLA Class I HistocompatIBility Antigen, Alpha Chain E; Leucocyte Antigen; MHC Class I Antigen E; HLA-E Protein; MHC Class IB Antigen; MHC Antigen;
Cat. No.: HY-P705388
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HLA-E; NonClassical MHC Class I Antigen; Major HistocompatIBility Complex, Class I, E; MHC Class I Antigen; HLA Class I HistocompatIBility Antigen, Alpha Chain E; Leucocyte Antigen; MHC Class I Antigen E; HLA-E Protein; MHC Class IB Antigen; MHC Antigen;
Cat. No.: HY-P705389
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HLA-E; NonClassical MHC Class I Antigen; Major HistocompatIBility Complex, Class I, E; MHC Class I Antigen; HLA Class I HistocompatIBility Antigen, Alpha Chain E; Leucocyte Antigen; MHC Class I Antigen E; HLA-E Protein; MHC Class IB Antigen; MHC Antigen;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
