97 Results for "

Claudin

" in MedChemExpress (MCE) Product Catalog:
Products (97)

97 Results for "Claudin" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-P99058
CAS No.: 1496553-00-4
Synonyms: IMAB362; Claudiximab; GC-182

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors .
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1
1 Cited Publications
Cat. No.: HY-113283
CAS No.: 451-13-8
Purity:  99.46%
Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as 1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .
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1
1 Cited Publications
Cat. No.: HY-153833
CAS No.: 2904682-19-3
Purity:  99.77%
Synonyms: KVA-E-23A
Target:  

Gap Junction Protein

Research Areas:  

Cancer

PDS-0330 is a specific and potent Claudin-1 inhibitor. PDS-0330 interferes with claudin-1/Src association and inhibits colorectal cancer (CRC) progression and metastasis .
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1
1 Cited Publications
Cat. No.: HY-P6083
CAS No.: 1995062-44-6
Research Areas:  

Others Cancer

RTSPSSR is synthesized peptide, which binds specifically to claudin-1 and visulizes the CRC tumor in mice, through near-infrared fluorescence imaging .
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Cat. No.: HY-N2468
CAS No.: 6860-47-5
Synonyms: 1,4-β-D-Xylobiose; 1,4-D-Xylobiose
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .
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Cat. No.: HY-P9991
CAS No.: 2460539-61-9
Synonyms: TST001

Target:  

Gap Junction Protein

Research Areas:  

Cancer

Osemitamab is an IgG1 antibody targeting to human claudin-18.2. Osemitamab consists of human-Mus musculus monoclonal TST001 γ1-chain, disulfide with human-Mus musculus monoclonal TST001 κ-chain, dimer (ACI). Osemitamab in combination with Capecitabine (HY-B0016) and Oxaliplatin (HY-17371), can be used for G/GEJ cancer study .
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Cat. No.: HY-W014507
CAS No.: 84-11-7
Target:  

Claudin

Research Areas:  

Cancer

9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5 that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis .
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Cat. No.: HY-P10580
CAS No.: 1359657-45-6
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury .
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Cat. No.: HY-P99413
CAS No.: 1650599-68-0
Synonyms: ASP1650

Target:  

HCV

Research Areas:  

Cancer

IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 + ovarian and testicular cancer cell lines .
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Cat. No.: HY-W015777
CAS No.: 105-13-5
Synonyms: P-Methoxy-benzyl alcoho; (4-Methoxyphenyl)methanol
4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcoho; (4-Methoxyphenyl) methanol) is a naturally derived volatile aromatic compound. 4-Methoxybenzyl alcohol upregulates the phosphorylation level of PI3K/Akt pathway proteins, downregulates the expression of pro-inflammatory factors, increases the content of tight junction proteins occludin and claudin-5, and alleviates structural damage to the blood-brain barrier. 4-Methoxybenzyl alcohol improves the decrease in viability and NO level of cerebral microvascular endothelial cells induced by oxygen-glucose deprivation/reperfusion, and reduces the release of lactate dehydrogenase. 4-Methoxybenzyl alcohol serves as a substrate in the two-phase persulfate-mediated electro-oxidation system, where it is directionally oxidized to p-anisaldehyde. 4-Methoxybenzyl alcohol acts as a substrate for wild-type fungal aryl alcohol oxidase. 4-Methoxybenzyl alcohol can be used in studies related to ischemic stroke, as well as in research across various fields such as chemical synthesis, including the synthesis of fragrances and flavorings .
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Cat. No.: HY-P991143
CAS No.: 3018936-99-4
Synonyms: TORL-1-23 Antibody

Target:  

Claudin ADC Antibodies

Research Areas:  

Cancer

Ixotatug (TORL-1-23 Antibody) is a monoclonal antibody targeting claudin-6 (CLDN6) that serves as the antibody component of the ADC drug Ixotatug vedotin (TORL-1-23). Ixotatug is applicable to research related to various cancers including ovarian cancer .
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Cat. No.: HY-P990742
CAS No.: 2762499-30-7
Synonyms: TJ-CD4B; ABL111; TJ033721

Target:  

TNF Receptor Claudin

Research Areas:  

Inflammation/Immunology Cancer

Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma .
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Cat. No.: HY-P10886
CAS No.: 1465809-36-2
Research Areas:  

Inflammation/Immunology

Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin–TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc .
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Cat. No.: HY-P10580A
Vasculotide TFA is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide TFA binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide TFA alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide TFA with antibiotics reduces lung injury .
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Cat. No.: HY-158990
CAS No.: 2883669-12-1
GE1111 is a MRGPRX2 antagonist (IC50 = 9.4 μM). GE1111 inhibits MRGPRX2/MRGPRB2-mediated mast cell activation. GE1111 reduces the expressions of TSLP, IL-13, MCP-1, TNF-α, IL-1β and periostin, maintains the expression levels of claudin 1 and involucrin, restores the phagocytic activity of macrophages, and attenuates the activation of STIM1 and phosphorylated AKT. GE1111 exerts anti-inflammatory and anti-allergic effects in multiple animal models. GE1111 is applicable to the research related to rosacea, atopic dermatitis and ulcerative colitis .
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Cat. No.: HY-171152A
Target:  

Claudin

Research Areas:  

Metabolic Disease

NSC 357754 dihydrochloride is an inhibitor of Claudin. NSC 357754 dihydrochloride can increase the transepithelial electrical resistance of cells and reduce the permeability of specific cations. NSC 357754 dihydrochloride can be used in the research of intestinal diseases mediated by Claudin-2 and/or Claudin-15 .
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Cat. No.: HY-P991163
CAS No.: 2969220-04-8

Target:  

CD3 Claudin

Research Areas:  

Cancer

Tixentamig is a bispecific monoclonal antibody targeting human CD3 ε and CLDN18 (claudin 18). Tixentamig is promising for research of cancers .
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Cat. No.: HY-100987
CAS No.: 14919-37-0
Research Areas:  

Others

Lauroylcarnitine chloride enhances the absorption of salmon calcitonin in rats. Also in determining in situ bioavailability, increased availability of Lucifer yellow and decreased expression of claudin-4 protein in the colon .
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Cat. No.: HY-P991679
CAS No.: 3038456-00-4
Synonyms: TORL-2-307 antibody

Target:  

Claudin

Research Areas:  

Cancer

Elatatug is an anti-CLDN18 (claudin 18) IgG1κ type humanized antibody with antineoplastic activity. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-N2468R
CAS No.: 6860-47-5
Synonyms: 1,4-β-D-Xylobiose (Standard); 1,4-D-Xylobiose (Standard)
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .
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