345 Results for "

Cyclooxygenase-2

" in MedChemExpress (MCE) Product Catalog:
Products (345)

345 Results for "Cyclooxygenase-2" in MCE Product Catalog:

  • Targets Recommended:
73
Acetaminophen
Acetaminophen
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73 Publications Verification
Cat. No.: HY-66005
CAS No.: 103-90-2
Synonyms: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide
Category:  

Alkaloids Monophenols Other Alkaloids Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Environmental Pollutants Endogenous Metabolite COX Histone Acetyltransferase Parasite Bacterial Ferroptosis

Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. [2] . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces ferroptosis and leads to acute liver injury in mice model .
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32
Cyclo(-RGDfK)
Cyclo(-RGDfK)
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32 Cited Publications
Cat. No.: HY-P0023
CAS No.: 161552-03-0
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface [2].
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32
Cyclo(-RGDfK) TFA
Cyclo(-RGDfK) TFA
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32 Cited Publications
Cat. No.: HY-P0023A
CAS No.: 500577-51-5
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
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21
NS-398
NS-398
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21 Cited Publications
Cat. No.: HY-13913
CAS No.: 123653-11-2
Purity:  99.71%
Target:  

COX

Research Areas:  

Inflammation/Immunology Cancer

NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
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18
Gallic acid
Gallic acid
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18 Cited Publications
Cat. No.: HY-N0523
CAS No.: 149-91-7
Synonyms: 3,4,5-Trihydroxybenzoic acid
Category:  

Anti-aging Metabolic Disease Plants Endogenous metabolite other families Microorganisms Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Cancer

Target:  

Free Radical Scavengers COX Reactive Oxygen Species (ROS) Apoptosis Ferroptosis Endogenous Metabolite

Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities [2].
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18
Gallic acid hydrate
Gallic acid hydrate
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18 Cited Publications
Cat. No.: HY-N0523A
CAS No.: 5995-86-8
Synonyms: 3,4,5-Trihydroxybenzoic acid hydrate
Category:  

Phenols Polyphenols Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

Free Radical Scavengers COX Reactive Oxygen Species (ROS) Apoptosis Ferroptosis Endogenous Metabolite

Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities [2].
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17
Alisporivir
Alisporivir
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17 Cited Publications
Cat. No.: HY-12559
CAS No.: 254435-95-5
Purity:  98.08%
Synonyms: Debio-025; DEB-025
Target:  

Cyclophilin HCV

Research Areas:  

Infection

Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
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16
Salicylic acid
Salicylic acid
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16 Cited Publications
Cat. No.: HY-B0167
CAS No.: 69-72-7
Synonyms: 2-Hydroxybenzoic acid
Category:  

Anti-aging Plants Endogenous metabolite Agricultural Research other families Monophenols Ketones, Aldehydes, Acids Phenols Phytohormone Disease Research Fields Inflammation/Immunology Cancer

Target:  

Environmental Pollutants Endogenous Metabolite COX Autophagy Apoptosis Mitophagy

Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Salicylic acid has blood-brain barrier permeability [2] .
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16
Sodium Salicylate
Sodium Salicylate
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16 Cited Publications
Cat. No.: HY-B0167A
CAS No.: 54-21-7
Synonyms: Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt
Category:  

Ketones, Aldehydes, Acids Asclepiadaceae Phenols Plants Periploca sepium Bunge Disease Research Fields Inflammation/Immunology Cancer

Target:  

Environmental Pollutants Ribosomal S6 Kinase (RSK) Endogenous Metabolite Apoptosis COX Autophagy NF-κB

Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .
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7
Cyclo(Phe-Pro)
Cyclo(Phe-Pro)
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7 Cited Publications
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Target:  

HCV Bacterial Antibiotic Reactive Oxygen Species (ROS)

Research Areas:  

Infection

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance [2] .
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5
Iloprost
Iloprost
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5 Cited Publications
Cat. No.: HY-A0096
CAS No.: 78919-13-8
Synonyms: Ciloprost; ZK 36374
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:  

Prostaglandin Receptor Endogenous Metabolite

Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research [2] .
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4
Ethyl Caffeate
Ethyl Caffeate
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4 Cited Publications
Cat. No.: HY-N6966
CAS No.: 102-37-4
Category:  

Phenols Polyphenols Amburana cearensis (Allemão) A.C.Sm. Plants Compositae Disease Research Fields Inflammation/Immunology Cancer

Target:  

NF-κB NO Synthase COX PGE synthase

Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin .
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4
Cyclo(RGDyK)
Cyclo(RGDyK)
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4 Cited Publications
Cat. No.: HY-100563A
CAS No.: 217099-14-4
Purity:  99.83%
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
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4
Cyclo(RGDyK) trifluoroacetate
Cyclo(RGDyK) trifluoroacetate
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4 Cited Publications
Cat. No.: HY-100563
CAS No.: 250612-42-1
Purity:  99.92%
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
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4
BQ-123
BQ-123
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4 Cited Publications
Cat. No.: HY-12378
CAS No.: 136553-81-6
Purity:  99.82%
Target:  

Endothelin Receptor

Research Areas:  

Cardiovascular Disease

BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension [2] .
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3
COX2 Antibody (YA493)
COX2 Antibody (YA493)
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3 Cited Publications
Cat. No.: HY-P80091
Synonyms: PTGS2; COX 2; COX2; COX-2; Cyclooxygenase; Cyclooxygenase2; Cyclooxygenase-2; hCox 2; PGG/HS; PGH synthase 2; PGHS 2; PGHS2; PHS 2; PHS II; PHS2 ; Prostaglandin endoperoxide synthase 2; Prostaglandin G/H synthase 2 precursor; Prostaglandin G/H synthase and Cyclooxygenase; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; TIS10II; PGH2_HUMAN.

Host:  

Rabbit

Application:  

WB, ICC/IF, IHC-P

Reactivity:  

Human, Mouse, Rat

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3
COX2 Antibody (YA791)
COX2 Antibody (YA791)
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3 Cited Publications
Cat. No.: HY-P80090
Synonyms: COX2, PTGS2, Prostaglandin G/H synthase 2, Cyclooxygenase-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, COX-2, PGH synthase 2, PGHS-2

Host:  

Mouse

Application:  

WB, IHC-P, FC

Reactivity:  

Human, Mouse, Rat

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3
Astressin
Astressin
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3 Cited Publications
Cat. No.: HY-P0257
CAS No.: 170809-51-5
Target:  

CRFR

Research Areas:  

Neurological Disease

Astressin is a potent corticotropin releasing factor (CRF) antagonist.
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3
Murepavadin TFA
Murepavadin TFA
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3 Cited Publications
Cat. No.: HY-P1674A
CAS No.: 3053070-05-3
Synonyms: POL7080 TFA
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance [2].
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2
Esculentoside A
Esculentoside A
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2 Cited Publications
Cat. No.: HY-N0632
CAS No.: 65497-07-6
Category:  

Triterpenes Terpenoids Phytolacca acinosa Roxb. Plants Disease Research Fields Inflammation/Immunology Phytolaccaceae

Target:  

COX NF-κB

Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models [2], has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .
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