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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
DCLK1
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "DCLK1" in MCE Product Catalog:
6
6 Cited Publications
Target:
Research Areas:
DCLK1-IN-1 is a selective, oral bioavailability in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1 kinase) domain. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases (IC50: DCLK1=9.5/57.2 nM and DCLK2=31/103 nM in binding and kinase assay, respectively). DCLK1-IN-1 shows low toxicity, and can investigate DCLK1 biology and establish its role in cancer, like DCLK1 + pancreatic ductal adenocarcinoma (PDAC) [1].
Cat. No.: HY-178776
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DCLK1-IN-6 (Compound 12n) is a Doublecortin-like kinase 1 (DCLK1) inhibitor with an IC50 of 58 nM. DCLK1-IN-6 significantly inhibits DCLK1 enzyme activity and its mediated inflammatory pathway. DCLK1-IN-6 has remarkable anti-inflammatory activity and significantly alleviates symptoms in acute lung injury (ALI) and sepsis mouse models. DCLK1-IN-6 can be used for acute inflammation diseases research [1].
Cat. No.: HY-RS03578
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DCLK1 Human Pre-designed siRNA Set A contains three designed siRNAs for DCLK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17338
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Dclk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dclk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23793
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Dclk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dclk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-163184
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DCLK1-IN-3 is a potent and selective doublecortin-like kinase 1 (DCLK1) inhibitor with an IC50 of 47 nM. DCLK1-IN-3 can be used for the research of cancer [1].
Cat. No.: HY-163185
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DCLK1-IN-4 (compound D2) is a potent and selective doublecortin-like kinase 1 (DCLK1) inhibitor with an IC50 of 70 nM. DCLK1-IN-4 can be used for the research of cancer [1].
Cat. No.: HY-155303
CAS No.: 2978517-43-8
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DCLK1-IN-2 (compound I-5) is a potent DCLK1 inhibitor with an IC50 of 171.3 nM. DCLK1-IN-2 shows remarkable antiproliferative effects on SW1990 cell lines (IC50 of 0.6 μM) and in vivo antitumor potency [1].
Cat. No.: HY-161471
CAS No.: 3028774-14-0
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DCLK1-IN-5 (Compound a24) is a DCLK1 inhibitor (IC50: 179.7 nM). DCLK1-IN-5 inhibits lipopolysaccharide (HY-D1056)-induced inflammation via inhibiting DCLK1-mediated IKKβ phosphorylation. DCLK1-IN-5 protects mice against inflammation-induced lung injury and sepsis [1].
Synonyms: (Z)-3,5,4'-Trimethoxystilbene
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cis-Trismethoxy resveratrol ((Z)-3,5,4'-Trimethoxystilbene) is an anti-HCV agent and Tubulin inhibitor, with an IC50 of 4 μM against Tubulin. cis-Trismethoxy resveratrol induces G2/M phase cell cycle arrest, reduces DCLK1, decreases CDK1 levels, blocks phosphorylation of Akt Ser 473, and induces the expression of p21 Cip1/Waf1. cis-Trismethoxy resveratrol exhibits anti-tumor and hepatoprotective activities. cis-Trismethoxy resveratrol can be used in studies related to colon adenocarcinoma, hepatocellular carcinoma, hepatitis C, and liver injury [1] .
Cat. No.: HY-P706034
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Serine/threonine-protein kinase DCLK1; Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; DCAMKL1; DCDC3A; KIAA0369
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Source:
Cat. No.: HY-P75308
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Serine/threonine-protein kinase DCLK1; Doublecortin-like kinase 1; DCAMKL1; DCDC3A
Species:
Source:
Cat. No.: HY-P702660
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Serine/threonine-protein kinase DCLK1; Doublecortin-like kinase 1; DCAMKL1; DCDC3A
Species:
Source:
Cat. No.: HY-P75307
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Serine/threonine-protein kinase DCLK1; Doublecortin-like kinase 1; DCAMKL1; DCDC3A
Species:
Source:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
