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Results for "

DLAT

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Natural
Products

2

Recombinant Proteins

5

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162386
    UM4118

    		Cuproptosis Mitochondrial Metabolism Cancer
    UM4118 is a potent copper-selective non-genotoxic copper ionophore that induces cuproptosis in acute myeloid leukemia cells. UM4118 exhibits stronger activity against SF3B1G12C mutant acute myeloid leukemia cells. UM4118 transports extracellular copper into cells, elevates intracellular and mitochondrial copper levels, and triggers lipoylated DLAT aggregation, proteotoxic stress, iron-sulfur cluster protein depletion, reduced lipoylated protein levels, and maximal mitochondrial respiratory damage. UM4118 cytotoxicity can be enhanced by supplementation with extracellular copper, abolished by copper chelation, and shows synthetic lethal effects in the absence of iron-sulfur cluster biosynthesis/transport genes. UM4118 can be used for the study of acute myeloid leukemia .
    UM4118
  • HY-116330
    Hyperforin

    		Calcium Channel TRP Channel Neurological Disease Inflammation/Immunology
    Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca 2+ levels by activating Ca 2+-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .
    Hyperforin
  • HY-RS17105
    Dlat Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dlat Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dlat gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dlat Mouse Pre-designed siRNA Set A
    Dlat Mouse Pre-designed siRNA Set A
  • HY-178914
    Copper ionophore I

    		Cuproptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism Cancer
    Copper ionophore I is an efficient copper ion carrier. Copper ionophore I can regulate various intracellular copper levels to induce cuproptosis, such as 4T1 (IC50 = 0.45 μM) and MDA-MB-231(IC50 = 1.21 μM) cells. Copper ionophore I can induce an increase in ROS and cause mitochondrial dysfunction. Copper ionophore I can reduce the expression of FDX1, DLAT, and LIAS proteins. Copper ionophore I can activate immune related pathways and promote T cell infiltration. Copper ionophore I can be used for cancer research .
    Copper ionophore I
  • HY-RS03792
    DLAT Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DLAT Human Pre-designed siRNA Set A contains three designed siRNAs for DLAT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DLAT Human Pre-designed siRNA Set A
    DLAT Human Pre-designed siRNA Set A
  • HY-RS23549
    Dlat Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dlat Rat Pre-designed siRNA Set A contains three designed siRNAs for Dlat gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dlat Rat Pre-designed siRNA Set A
    Dlat Rat Pre-designed siRNA Set A

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