20 Results for "

DR4

" in MedChemExpress (MCE) Product Catalog:
Products (20)

20 Results for "DR4" in MCE Product Catalog:

  • Targets Recommended:
59
59 Cited Publications
Cat. No.: HY-17409
CAS No.: 1400-61-9
Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .
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1 Cited Publications
Cat. No.: HY-P99934
CAS No.: 1820660-69-2
Synonyms: ABBV-621

Research Areas:  

Cancer

Eftozanermin alfa (ABBV-621) is a tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa is a fusion protein consisting of a mutant immunoglobulin G1-Fc linked to 2 single-chain trimers of TRAIL. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors (DR4 receptor and DR5 receptor) with Kds of 780 nM and 635 nM. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .
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Cat. No.: HY-P990715
CAS No.: 2539847-03-3
Synonyms: INBRX-109

Target:  

TNF Receptor

Research Areas:  

Cancer

Ozekibart (INBRX-109) is a DR5 agonist and antitumor agent with a human DR5 IC50 of 0.17 nmol/L and human DR5 Ka of 0.11 nmol/L. Ozekibart can be used for the research of unresectable/metastatic chondrosarcoma .
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Cat. No.: HY-157269
CAS No.: 1069110-72-0
Target:  

Hapten

Research Areas:  

Inflammation/Immunology

J10-1 is a hapten small molecule. J10-1 accelerates peptide exchange in MHC class II molecules in an HLA-DM-independent manner, and its effect is not affected by the polymorphism of the P1 pocket of MHC class II molecules. J10-1 enhances the processes of peptide dissociation, peptide binding and peptide association of MHC class II molecules on the surface of B cells. J10-1 can be used for research on immunoregulation .
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Cat. No.: HY-120794
CAS No.: 182134-00-5
Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

SC 67655 is a potent and stable pentapeptide MHC class II haplotype DR4 (DR4 Dw4 or DRB 1"0401) ligand with an IC50 of 50 nM. SC 67655 can be used for the study of autoimmune diseases .
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Cat. No.: HY-P3639
CAS No.: 320341-56-8
Target:  

TNF Receptor

Research Areas:  

Others

SYLQDSVPDSFQD, anchor-modified for high-affinity binding to DR4, is a DR4-restricted MHC class II peptide Tyrosinase .
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Cat. No.: HY-P1901
CAS No.: 872036-64-1
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

Insulin alpha-chain (1-13) is a human leucocyte antigen (HLA)-DR4-restricted epitope comprising the first 13 amino acids of the insulin A-chain .
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Cat. No.: HY-P11902
Research Areas:  

Cancer

IRS1 is an integrin-targeted, ROS-responsive self-assembling peptide prodrug molecule with selective anti-cancer activity against integrin-overexpressing tumor cells. IRS1 contains an RGD motif for integrin binding, can covalently bind to DR4/DR5, and promotes DR4/DR5 aggregation. After oxidation by ROS, IRS1 undergoes a morphological transition from nanoparticles to nanofibers, exposes the pharmacophore of Chlorambucil (HY-13593), disrupts cell membrane integrity, activates the extrinsic apoptosis pathway, and can penetrate and inhibit the three-dimensional uveal melanoma spheroid model. IRS1 can be used for the research of uveal melanoma .
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Cat. No.: HY-P87245
Synonyms: DR 4 antibody

Host:  

Rabbit

Application:  

WB, IHC-P, FC

Reactivity:  

Human

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Cat. No.: HY-181955
MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins. MS1129 upregulates TRAIL, DR4 and DR5 proteins, downregulates the decoy receptor DcR2, and activates TRAIL-dependent apoptosis via the HIF-1/2 and Caspase-10 pathways. MS1129 is applicable to the research of VHL-deficient clear cell renal cell carcinoma .
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Cat. No.: HY-RS06213
Research Areas:  

Others

HLA-DRB4 Human Pre-designed siRNA Set A contains three designed siRNAs for HLA-DRB4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS14795
Research Areas:  

Others

TNFRSF10A Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF10A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P78529
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF10A; Death Receptor 4; TNF Receptor Superfamily Member 10a; TRAIL Receptor 1; TRAILR1; TRAIL-R1; DR4; Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2; TRAILR-1; Tumor Necrosis Factor Receptor Superfamily Member 10a; CD261; Alternativ
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P74500
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10A; Death Receptor 4; TNF Receptor Superfamily Member 10a; TRAIL Receptor 1; TRAILR1; TRAIL-R1; DR4; Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2; TRAILR-1; Tumor Necrosis Factor Receptor Superfamily Member 10a; CD261; Alternativ
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P78219
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF10A; Death Receptor 4; TNF Receptor Superfamily Member 10a; TRAIL Receptor 1; TRAILR1; TRAIL-R1; DR4; Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2; TRAILR-1; Tumor Necrosis Factor Receptor Superfamily Member 10a; CD261; Alternativ
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P74501
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10A; Death Receptor 4; TNF Receptor Superfamily Member 10a; TRAIL Receptor 1; TRAILR1; TRAIL-R1; DR4; Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2; TRAILR-1; Tumor Necrosis Factor Receptor Superfamily Member 10a; CD261; Alternativ
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P72440
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF10A; Death Receptor 4; TNF Receptor Superfamily Member 10a; TRAIL Receptor 1; TRAILR1; TRAIL-R1; DR4; Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2; TRAILR-1; Tumor Necrosis Factor Receptor Superfamily Member 10a; CD261; Alternativ
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-183390
CAS No.: 136565-26-9
Scopadulciol is an orally effective β-catenin degrader, HSV-TK activator and proton pump inhibitor. By inducing β-catenin degradation, Scopadulciol downregulates the expression of downstream target genes such as cyclin D1, c-myc, and survivin; it also upregulates DR4/DR5 and downregulates Bcl-2, thereby exerting cytotoxicity and inducing apoptosis in cancer cells. Scopadulciol enhances the tumor-killing and bystander effects of prodrugs via activating HSV-TK, and can inactivate HSV-1. It shows synergistic antiviral effects when combined with Acyclovir (HY-17422) or Ganciclovir (HY-13637), with no cytotoxicity as a single agent. Scopadulciol can be applied in research related to bladder cancer, cervical cancer, glioblastoma, and digestive system cancers [4].
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Cat. No.: HY-P87404A
Synonyms: CD261, APO2, DR4, TRAILR1, TNFRSF10A, Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1

Host:  

Rabbit

Application:  

WB, ICC/IF, FC

Reactivity:  

Human

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Cat. No.: HY-P87404

Host:  

Rabbit

Application:  

WB, ICC/IF, FC

Reactivity:  

Human

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