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Results for "

DcpS

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

1

Fluorescent Dye

2

Antibodies

8

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108599
    DCP-LA
    5+ Cited Publications

    FR236924

    		 PKC CaMK Phosphatase Apoptosis Neurological Disease
    DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( 2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis .
    DCP-LA
  • HY-102020
    RG3039
    3 Publications Verification

    PF-06687859

    		 DNA/RNA Synthesis Neurological Disease
    RG3039 (PF-06687859) is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC50 of 4.2 nM against hDcpS. RG3039 inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 extends survival and improves function in spinal muscular atrophy mice. RG3039 is applicable to research related to spinal muscular atrophy .
    RG3039
  • HY-W087905
    2,3-Dimethyl-2,3-diphenylbutane

    		Biochemical Assay Reagents Others
    2,3-Dimethyl-2,3-diphenylbutane is a minor product formed during the thermal decomposition of dicumyl peroxide (DCP) in cumene, generated through radical coupling reactions. As an initiator capable of producing free radicals, 2,3-dimethyl-2,3-diphenylbutane promotes cross-linking or decomposition processes via initiating free radical reactions in fields such as polymer polymerization (e.g., modification of polyphenylene oxide processing), organic synthesis (e.g., DCP decomposition reactions), and coal processing (e.g., oxidation stabilization of coal tar pitch), thereby enhancing material properties or reaction efficiency .
    2,3-Dimethyl-2,3-diphenylbutane
  • HY-145969
    β-S-ARCA

    3'-O-Me-m7G(5')ppp(5')G

    		 DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF) Cancer
    β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA has been applied in researching experimental mRNA-based anticancer vaccines .
    β-S-ARCA
  • HY-145969A
    β-S-ARCA triammonium

    3’-O-Me-m7G(5')ppp(5')G triammonium

    		 DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF) Cancer
    β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) triammonium is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA triammonium binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA triammonium prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA triammonium has been applied in researching experimental mRNA-based anticancer vaccines .
    β-S-ARCA triammonium
  • HY-122604
    PF-DcpSi

    		DNA/RNA Synthesis Neurological Disease
    PF-DcpSi is a mRNA decapping scavenger enzyme (DcpS) inhibitor (IC50: 0.11 nM). PF-DcpSi (30 mg/kg,i.p.) ameliorates the disease phenotype in a mice model of spinal muscular atrophy (SMA) .
    PF-DcpSi
  • HY-131933
    DCP-Bio3

    		Fluorescent Dye Others
    DCP-Bio3 is a biotinylated probe that can detect labeled proteins in polyacrylamide gels. DCP-Bio3 can be used in research for the identification of oxidized and modified proteins .
    DCP-Bio3
  • HY-164977
    JCS-1

    		PROTACs Phosphatase Cancer
    JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations (DC50 in MOLM-14 cells: 87 nM). JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders (Pink: DcpS ligand (HY-102020); Blue: E3 ligase VHL ligand (HY-151227); Black: linker (HY-141230)) .
    JCS-1
  • HY-RS03587
    DCPS Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DCPS Human Pre-designed siRNA Set A contains three designed siRNAs for DCPS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DCPS Human Pre-designed siRNA Set A
    DCPS Human Pre-designed siRNA Set A
  • HY-RS27223
    Dcps Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dcps Rat Pre-designed siRNA Set A contains three designed siRNAs for Dcps gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dcps Rat Pre-designed siRNA Set A
    Dcps Rat Pre-designed siRNA Set A
  • HY-155771
    1-DCP

    		Biochemical Assay Reagents Others
    1-DCP is a potent ethylene antagonist. 1-DCP can inhibit the role of ethylene in fruit ripening and senescence .
    1-DCP
  • HY-138147
    DCP-Rho1

    		Fluorescent Dye Others
    DCP-Rho1 is a rhodamine-labeled probe. DCP-Rho1 can be used for the detection of sulfenic acid-containing proteins. DCP-Rho1 shows λex of 560 nM, λem, 581 nm .
    DCP-Rho1
  • HY-108599R
    DCP-LA (Standard)

    FR236924 (Standard)

    		 Reference Standards PKC CaMK Phosphatase Apoptosis Neurological Disease
    DCP-LA (Standard) is the analytical standard of DCP-LA. This product is intended for research and analytical applications. DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis[1][2][3].
    DCP-LA (Standard)
  • HY-RS03584
    DCP1A Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DCP1A Human Pre-designed siRNA Set A contains three designed siRNAs for DCP1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DCP1A Human Pre-designed siRNA Set A
    DCP1A Human Pre-designed siRNA Set A
  • HY-RS03586
    DCP2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DCP2 Human Pre-designed siRNA Set A contains three designed siRNAs for DCP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DCP2 Human Pre-designed siRNA Set A
    DCP2 Human Pre-designed siRNA Set A
  • HY-RS03585
    DCP1B Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DCP1B Human Pre-designed siRNA Set A contains three designed siRNAs for DCP1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DCP1B Human Pre-designed siRNA Set A
    DCP1B Human Pre-designed siRNA Set A
  • HY-RS20712
    Dcps Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dcps Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dcps gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dcps Mouse Pre-designed siRNA Set A
    Dcps Mouse Pre-designed siRNA Set A
  • HY-102020A
    RG3039 hydrochloride

    		DNA/RNA Synthesis Neurological Disease
    RG3039 hydrochloride is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC50 of 4.2 nM against hDcpS. RG3039 hydrochloride inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 hydrochloride extends survival and improves function in spinal muscular atrophy mice. RG3039 hydrochloride is applicable to research related to spinal muscular atrophy .
    RG3039 hydrochloride
  • HY-102020R
    RG3039 (Standard)

    PF-06687859 (Standard)

    		 DNA/RNA Synthesis Reference Standards Neurological Disease
    RG3039 (Standard) is the analytical standard of RG3039 (HY-102020). This product is intended for research and analytical applications. RG3039 (PF-06687859) is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC50 of 4.2 nM against hDcpS. RG3039 inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 extends survival and improves function in spinal muscular atrophy mice. RG3039 is applicable to research related to spinal muscular atrophy .
    RG3039 (Standard)
  • HY-178672A
    ARCA triammonium solution (100 mM)

    Anti-Reverse cap analog triammonium solution (100 mM); m2 7,3′O GpppG triammonium solution (100 mM)

    		 DNA/RNA Synthesis Cancer
    ARCA (Anti-Reverse cap analog) triammonium solution (100 mM) is a 5′-cap analogue. ARCA triammonium solution (100 mM) caps mRNA. ARCA triammonium solution (100 mM) can be used in protein expression studies .
    ARCA triammonium solution (100 mM)

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