Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
FFAR
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "FFAR" in MCE Product Catalog:
4
Category:
4
4 Cited Publications
Target:
Free Fatty Acid Receptor Histone Methyltransferase HDAC mTOR CaMK p38 MAPK Epigenetic Reader Domain GLUT nAChR TNF Receptor
Research Areas:
AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3) (IC50=117 nM). AR420626 has anti-inflammatory, anticancer and antidiabetic activities. AR420626 improves neurogenic diarrhea by inhibiting nAChR mediated neural pathways. AR420626 inhibits the growth of HepG2 xenografts and inhibits the proliferation of hepatoma cells by inducing apoptosis. AR420626 also suppresses allergic asthma and eczema and has the ability to activate GPR41 to increase Ca 2+ signal-mediated glucose uptake and improve diabetes .
3
3 Cited Publications
Target:
Research Areas:
DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca 2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively) . DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis .
1
1 Cited Publications
Cat. No.: HY-W040127
CAS No.: 6906-39-4
Category:
Vitaceae Extract Anthocyans Plant Flavonoids Metabolic Disease Disease Research Fields Vitis vinifera cv. Zalema Extract
Target:
Target:
Research Areas:
ZQ-16 is a potent and selective GPR84 agonist with an EC50 value of 0.213 μM. ZQ-16 has no activity on the other free fatty acid receptors (FFARs), including GPR40, GPR41, GPR119 and GPR120 .
Cat. No.: HY-W009081
CAS No.: 2433-96-7
Target:
Target:
Research Areas:
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) (Free Fatty Acid Receptor) agonist with a pEC50 of 7.39. TUG-499 exhibits >100-fold selectivity over the related receptors FFA2, FFA3, and the nuclear receptor PPARγ and other diverse receptors, ion channels, and transporters. TUG-499 can be used for the research of type 2 diabetes . TUG-499 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target:
Research Areas:
GPR40/FFAR1 modulator 1 is an agonist and an allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) .
Target:
Research Areas:
CFMB is a full agonist of FFAR2- and FFAR3-specific with EC50 value of 0.8 μM target hFFAR2 and 0.2 μM target rFFAR2 .
Target:
Research Areas:
Icosabutate is an orally active engineered fatty acid and a dual FFAR1/FFAR4 (GPR40/GPR120) agonist with EC50 values of 10 μM and 15.5 μM, respectively. Icosabutate acts as a partial agonist of PPAR-α, with an EC50 of 208 nM. Icosabutate inhibits the arachidonic acid cascade and exhibits antioxidant and anti-apoptotic activities. Icosabutate can be used in the research of nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis, and atherosclerosis .
Target:
Research Areas:
GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist with an EC50 of 0.058 μM .
Cat. No.: HY-N3977
CAS No.: 80557-12-6
Target:
Cat. No.: HY-162689
Target:
Research Areas:
GprA is a new synthetic agonist of G-protein-coupled receptor 120/free fatty acid receptor 4 (GPR120/FFAR4), with an AC50 of 203 nM on human GPR120 full isoform. GprA can be used in the research for NAFLD .
Cat. No.: HY-RS04875
Target:
Research Areas:
FFAR2 Human Pre-designed siRNA Set A contains three designed siRNAs for FFAR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17461
Target:
Research Areas:
Ffar3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ffar3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-114060A
CAS No.: 2182298-09-3
Target:
Research Areas:
(R)-CFMB is the R-enantiomer of CFMB (HY-114060). CFMB is an agonist of FFAR2- and FFAR3-specific with an EC50 value of 0.8 μM target hFFAR2 and 0.2 μM target rFFAR2 .
Cat. No.: HY-148235
CAS No.: 858097-86-6
Target:
Research Areas:
TP-051, a chemical probe, is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes .
Cat. No.: HY-164870
CAS No.: 2839486-16-5
Target:
Research Areas:
FFAR1/FFAR4 agonist-1 (compound 83) is a FFAR1/FFAR4 agonist with the EC50 of 1 nM A and 4nM for FFAR1 and FFAR4, respectively. FFAR1/FFAR4 agonist-1 can be used for study of glycemic control .
Cat. No.: HY-147420
CAS No.: 2230597-99-4
Synonyms: IDG-16177
Research Areas:
Xelaglifam is an orally active GPR40/FFAR1 agonist and PPARγ coactivator recruitment inhibitor (IC50 74.7 µM). Xelaglifam activates Gq/IP3/Ca 2+ and β-arrestin, stimulates glucose-dependent insulin secretion from pancreatic β cells, improves glucose tolerance, reduces fasting hyperglycemia, protects pancreatic β cells, inhibits DP1, BSEP (IC50 14.3 µM), MRP2 (39.9 µM) and MRP4 (4.4 µM), activates FXR, regulates bile acid homeostasis, and modulates mitochondrial function, membrane potential and cellular ATP. Xelaglifam can be used for research on type 2 diabetes .
Cat. No.: HY-RS04877
Target:
Research Areas:
FFAR4 Human Pre-designed siRNA Set A contains three designed siRNAs for FFAR4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
