FGL1

By Targets:	LAG-3 (4) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (3) Inflammation/Immunology (2) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99156

Relatlimab 3 Publications Verification BMS-986016	LAG-3	Cancer
Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC₅₀ value of 0.67 nM and LAG-3/FGL1 interaction with an IC₅₀ value of 0.019 nM. Relatlimab can be used in research of cancer ^[1].

HY-RS17106

Fgl1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fgl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fgl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgl1 Mouse Pre-designed siRNA Set A Fgl1 Mouse Pre-designed siRNA Set A

HY-RS23550

Fgl1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fgl1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fgl1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgl1 Rat Pre-designed siRNA Set A Fgl1 Rat Pre-designed siRNA Set A

HY-RS04927

FGL1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FGL1 Human Pre-designed siRNA Set A contains three designed siRNAs for FGL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FGL1 Human Pre-designed siRNA Set A FGL1 Human Pre-designed siRNA Set A

HY-P990243

*Anti-Mouse FGL-1* Antibody (177R4)**	LAG-3	Inflammation/Immunology Cancer
Anti-Mouse FGL-1 Antibody (177R4) is an anti-mouse *FGL-1* IgG2a monoclonal antibody. Anti-Mouse FGL-1 Antibody (177R4) can increase CD8 ⁺ T cell infiltration. Anti-Mouse FGL-1 Antibody (177R4) enhances the anti-tumor immune effect by blocking FGL1. Anti-Mouse FGL-1 Antibody (177R4) can be used for research on cancer such as lung cancer and breast cancer ^[1] .

HY-164308

SA-15-P	LAG-3	Inflammation/Immunology
SA-15-P inhibits LAG-3/MHCII and *LAG-3/FGL1* interactions with IC₅₀ values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies ^[1].

HY-P992461

SHR-1802	LAG-3	Cancer
SHR-1802 is a humanized anti-LAG-3 monoclonal antibody.SHR-1802 specifically binds to LAG-3 and inhibits its binding to major histocompatibility complex class II (MHC-II), fibrinogen-like protein 1 (FGL1), galectin-3, and liver sinusoidal endothelial cell lectin.SHR-1802 can be used for the research of advanced solid tumors ^[1].

HY-P992352

ES005
ES005 is an anti-tumor compound and LAG3 inhibitor. ES005 blocks the interactions of LAG3 with MHC-II, LSECtin and *FGL1*, thereby effectively reversing the LAG3-mediated inhibition of T cell activation and NFAT reporter gene expression. ES005 exhibits significant tumor growth inhibitory effects in syngeneic mouse breast tumor models using humanized LAG3 knock-in mice. ES005 can be used for breast tumor-related research ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P3532

*[Glp1]-FGL* peptide acetate** 1 Publications Verification [pGlu1]-FGL peptide acetate; [Pyr1]-FGL peptide acetate	Peptides	Neurological Disease
[Glp1]-FGL peptide acetate is a neural cell adhesion molecule (NCAM) derived motif and can be used for the research of neurogenesis ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99156

Relatlimab 3 Publications Verification BMS-986016	LAG-3	Cancer
Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC₅₀ value of 0.67 nM and LAG-3/FGL1 interaction with an IC₅₀ value of 0.019 nM. Relatlimab can be used in research of cancer ^[1].

HY-P990243

*Anti-Mouse FGL-1* Antibody (177R4)**	LAG-3	Inflammation/Immunology Cancer
Anti-Mouse FGL-1 Antibody (177R4) is an anti-mouse *FGL-1* IgG2a monoclonal antibody. Anti-Mouse FGL-1 Antibody (177R4) can increase CD8 ⁺ T cell infiltration. Anti-Mouse FGL-1 Antibody (177R4) enhances the anti-tumor immune effect by blocking FGL1. Anti-Mouse FGL-1 Antibody (177R4) can be used for research on cancer such as lung cancer and breast cancer ^[1] .

HY-P992461

SHR-1802	LAG-3	Cancer
SHR-1802 is a humanized anti-LAG-3 monoclonal antibody.SHR-1802 specifically binds to LAG-3 and inhibits its binding to major histocompatibility complex class II (MHC-II), fibrinogen-like protein 1 (FGL1), galectin-3, and liver sinusoidal endothelial cell lectin.SHR-1802 can be used for the research of advanced solid tumors ^[1].

HY-P992352

ES005
ES005 is an anti-tumor compound and LAG3 inhibitor. ES005 blocks the interactions of LAG3 with MHC-II, LSECtin and *FGL1*, thereby effectively reversing the LAG3-mediated inhibition of T cell activation and NFAT reporter gene expression. ES005 exhibits significant tumor growth inhibitory effects in syngeneic mouse breast tumor models using humanized LAG3 knock-in mice. ES005 can be used for breast tumor-related research ^[1].

Recombinant Proteins Recommended:

FGL-1

Species:	Human (12) Rat (1) Mouse (2) Cynomolgus (4)
Tag:	His (9) Avi (5) Fc (10)
Source:	HEK293 (16) Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78443

	FGL1 protein, Human (242a.a, HEK293, His-Avi) FGL1; FGL-1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1; Lag3 ligand	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth.FGL1 protein, Human (242a.a, HEK293, His-Avi) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P701077

	FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, hFc) FGL1; FGL-1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1; Lag3 ligand	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, hFc) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P78128

	FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, His-Avi) FGL1; FGL-1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1; Lag3 ligand	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (Biotinylated, 242a.a, HEK293, His-Avi) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with N-Avi, N-His labeled tag.

HY-P72642

	FGL1 Protein, Cynomolgus (HEK293, His) Fibrinogen like 1; FGL1	Cynomolgus	HEK293
	Fibrinogen like 1 (FGL1) is a proliferation- and metabolism-related protein secreted by the liver. FGL1 is also upregulated in tumor tissues. FGL1 is a checkpoint ligand of lymphocyte activation gene 3 (LAG3). When binding to LAG3, FGL1 can inhibit T cell activation and proliferation. FGL1 can be used for research of immune checkpoint therapy. FGL1 plays a role in proliferation, metabolism, apoptosis, epithelial-to-mesenchymal transition, and immune infiltration. FGL1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived FGL1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78589

	FGL1 Protein, Cynomolgus (HEK293, mFc) FGL1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1	Cynomolgus	HEK293
	FGL1 Protein, a potent immune suppressive molecule, inhibits antigen-specific T-cell activation as a major ligand for LAG3. It crucially contributes to LAG3-mediated T-cell inhibitory functions, independently of MHC class II. Secreted by hepatocytes, FGL1 also promotes their growth. The homodimeric form of the protein interacts with LAG3, specifically engaging with its Ig-like domains 1 and 2 through the Fibrinogen C-terminal domain. FGL1 Protein, Cynomolgus (HEK293, mFc) is the recombinant cynomolgus-derived FGL1 protein, expressed by HEK293 , with N-mFc labeled tag.

HY-P78875

	FGL1 Protein, Human (Biotinylated, HEK293, Fc-Avi) FGL1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag.

HY-P70740

	FGL1 Protein, Human (HEK293, mFc) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, mFc) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P70737A

	FGL1 Protein, Human (HEK293, His) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, His) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704612

	FGL1 Protein, Human (HEK293, Fc) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, Fc) is the recombinant human-derived FGL1 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P75188

	FGL1 Protein, Mouse (sf9, His) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Mouse	Sf9 insect cells
	FGL1 Protein, a potent immune suppressive molecule, inhibits antigen-specific T-cell activation as a major ligand for LAG3. It crucially contributes to LAG3-mediated T-cell inhibitory functions, independently of MHC class II. Secreted by hepatocytes, FGL1 also promotes their growth. The homodimeric form of the protein interacts with LAG3, specifically engaging with its Ig-like domains 1 and 2 through the Fibrinogen C-terminal domain. FGL1 Protein, Mouse (sf9, His) is the recombinant mouse-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P77366

	FGL1 Protein, Cynomolgus (HEK293, Fc) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Cynomolgus	HEK293
	FGL1 is a specific hepatocyte mitogen, regulates the expression of proliferative factors, promoting liver regeneration and repairing liver injury. FGL1 inhibits T-cell activation by binding to LAG3. FGL1 promotes cell proliferation by activating the ERK/p-ERK pathway. FGL1 inhibits apoptosis of non-small cell lung cancer (NSCLC) cells by inhibiting PARP1/caspase 3 pathway. FGL1 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived FGL1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75771

	FGL1 Protein, Rat (sf9, His) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Rat	Sf9 insect cells
	The FGL1 protein is a key immunosuppressant that acts as the primary ligand of LAG3 to inhibit antigen-specific T cell activation. FGL1 is essential for the T cell suppressor function of LAG3, which is independent of MHC class II (MHC-II) binding. FGL1 is secreted by hepatocytes and actively promotes their growth. FGL1 Protein, Rat (sf9, His) is the recombinant rat-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P77367

	FGL1 Protein, Cynomolgus (sf9, His) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Cynomolgus	Sf9 insect cells
	FGL1 is a specific hepatocyte mitogen, regulates the expression of proliferative factors, promoting liver regeneration and repairing liver injury. FGL1 inhibits T-cell activation by binding to LAG3. FGL1 promotes cell proliferation by activating the ERK/p-ERK pathway. FGL1 inhibits apoptosis of non-small cell lung cancer (NSCLC) cells by inhibiting PARP1/caspase 3 pathway. FGL1 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived FGL1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P75189

	FGL1 Protein, Mouse (HEK293, hFc) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Mouse	HEK293
	The FGL1 protein has signaling receptor binding activity and negatively regulates T cell activation and immune response. It is involved in adipose tissue development, cholesterol metabolism, and response to stilbenoid. FGL1 is located in the extracellular region and is orthologous to the human FGL1 gene. It is primarily expressed in the liver at the E18 stage. FGL1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived FGL1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70737

	FGL1 Protein, Human (HEK293, His, solution) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, His, solution) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78876

	FGL1 Protein, Human (Biotinylated, 249a.a, HEK293, Fc-Avi) FGL1; Hepassocin; HP-041; HFREP-1; LFIRE-1; HFREP1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (Biotinylated, 249a.a, HEK293, Fc-Avi) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag. The total length of FGL1 Protein, Human (Biotinylated, 249a.a, HEK293, Fc-Avi) is 249 a.a., with molecular weight of 110-120 kDa.

HY-P70740A

	FGL1 Protein, Human (HEK293, mFc, solution) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (HEK293, mFc, solution) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P72369

	FGL1 Protein, Human (Biotinylated, HEK293, Avi-His) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived FGL1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P704613

	FGL1 Protein, Human (249a.a, HEK293, Fc) Fibrinogen-like protein 1; FGL1; HP-041; Hepassocin; HFREP-1; LFIRE-1	Human	HEK293
	FGL1 protein is the main ligand of LAG3 and can inhibit antigen-specific T cell activation, mediating the inhibitory function of LAG3 independently of MHC-II binding. FGL1 is secreted by liver cells and contributes to their growth. FGL1 Protein, Human (249a.a, HEK293, Fc) is the recombinant human-derived FGL1 protein, expressed by HEK293, with N-hFc labeled tag.

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Source
Tag
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Gene ID
Molecular Weight
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (2)
Reactivity:	Human (2)
Application:	IHC-P (2) ICC/IF (2) FC (2) ELISA (2)
Isotype:	IgG2a (2)
Conjugation:	Non-conjugated (2) Biotin (5)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84514

	FGL1 Antibody (YA4211) HPS; HFREP1; HP-041; LFIRE1; LFIRE-1	IHC-P, ICC/IF, FC, ELISA	Human
	FGL1 Antibody (YA4211) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to FGL1.

HY-P84514A

	FGL1 Antibody (YA4211)(PBS only) HPS; HFREP1; HP-041; LFIRE1; LFIRE-1	IHC-P, ICC/IF, FC, ELISA	Human
	FGL1 Antibody (YA4211) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to FGL1.

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Products	In-stock - + Add to Cart
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS17106

Fgl1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Fgl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fgl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23550

Fgl1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Fgl1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fgl1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04927

FGL1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FGL1 Human Pre-designed siRNA Set A contains three designed siRNAs for FGL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Recombinant Proteins

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Oligonucleotides