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FOXO3a

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FOXO (1) Akt (7) Androgen Receptor (1) Apoptosis (8) Autophagy (2) Bacterial (1) CDK (1) Drug Derivative (1) EGFR (2) ERK (1) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (1) Mitochondrial Metabolism (1) MMP (1) mTOR (1) nAChR (1) NF-κB (1) NO Synthase (1) Organoid (2) P-glycoprotein (1) p38 MAPK (2) Paraptosis (1) Phosphatase (3) Phosphodiesterase (PDE) (2) PhosTACs (3) PI3K (3) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Sirtuin (1) Small Interfering RNA (siRNA) (3) Tau Protein (1) TNF Receptor (2) VEGFR (1)
By Research Areas:	Cancer (13) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: FOXO

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15186

Ipatasertib Maximum Cited Publications 60 Publications Verification GDC-0068; RG7440	Organoid Akt Apoptosis	Cancer
Ipatasertib (GDC-0068) is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀ values of 5, 18, 8 nM for *Akt1/2/3, respectively. Ipatasertib synchronously activates FoxO3a* and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models .

HY-16558

Butein 5+ Cited Publications 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a ^[3]. Butein is a SIRT1 activator (STAC).

HY-153347

JY-2 2 Publications Verification	FOXO	Metabolic Disease
JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC₅₀ of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity .

HY-145232

PhosTAC7 4 Publications Verification OGTAC-3	PhosTACs Phosphatase Tau Protein	Neurological Disease Cancer
PhosTAC7 is a heterobifunctional molecule named as a Phosphorylation Targeting Chimera (PhosTAC). PhosTAC7 can dephosphorylate the PDCD4 protein, *FOXO3a* protein, and tau protein by recruiting serine/threonine protein phosphatase 2A (PP2A). PhosTAC7 offers the advantage of selectively modulating the phosphorylation state of individual target proteins, making it a promising tool for research in cancer and tau protein-related neurodegenerative diseases (Alzheimer's disease) .

HY-N2255

Crebanine 4 Publications Verification	Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial	Cancer
Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC₅₀ of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the *AKT/FoxO3a, NF-κB* and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na ⁺ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease ^[3] .

HY-148508

PhosTAC3	PhosTACs Phosphatase	Cancer
PhosTAC3 is a phosphorylation targeting chimera (PhosTAC) molecule composed of a linker with three PEG groups. PhosTAC3 induces dephosphorylation of PDCD4 and FOXO3a .

HY-148509

PhosTAC5	PhosTACs Phosphatase	Cancer
PhosTAC5 is a phosphorylation targeting chimera (PhosTAC) molecule composed of a linker with fivePEG groups. PhosTAC5 induces dephosphorylation of PDCD4 and FOXO3a .

HY-RS05070

FOXO3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FOXO3 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXO3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FOXO3 Human Pre-designed siRNA Set A FOXO3 Human Pre-designed siRNA Set A

HY-15615A

Dordaviprone 5+ Cited Publications TIC10; ONC-201	TNF Receptor Apoptosis	Cancer
Dordaviprone (TIC10) is a potent, orally active, and stable tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. Dordaviprone can cross the blood-brain barrier .

HY-16558R

Butein (Standard) 2’,3,4,4’-tetrahydroxy Chalcone (Standard)	Reference Standards EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a ^[3]. Butein is a SIRT1 activator (STAC).

HY-130133

DHW-221	PI3K mTOR Akt Apoptosis Paraptosis p38 MAPK Mitochondrial Metabolism P-glycoprotein CDK MMP HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
DHW-221 is a potent orally active dual *PI3K/mTOR* inhibitor, exhibiting low nanomolar potency against all four Class I PI3K isoforms and mTOR (PI3Kα, IC₅₀ = 0.50 nM; PI3Kβ, IC₅₀ = 1.9 nM; PI3Kγ, IC₅₀ = 1.8 nM; PI3Kδ, IC₅₀ = 0.74 nM; mTOR, IC₅₀ = 3.9 nM). DHW-221 exerts antitumor effects by blocking the *PI3K/Akt/mTOR* pathway and inducing mitochondrial apoptosis and paraptosis (via Endoplasmic Reticulum (ER) stress and MAPK signaling) and arrests cell cycle, thereby inhibiting cell migration, invasion and angiogenesis. DHW-221 inhibits tumor growth in both the A549/Taxol (HY-B0015) and the HCC827 xenograft mouse models. DHW-221 can be used for non-small cell lung cancer (NSCLC), colon and breast cancer research ^[3].

HY-15186C

Ipatasertib tosylate GDC-0068 tosylate; RG7440 tosylate	Organoid Akt Apoptosis	Cancer
Ipatasertib (GDC-0068) tosylate is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀ values of 5, 18, 8 nM for *Akt1/2/3, respectively. Ipatasertib tosylate synchronously activates FoxO3a* and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib tosylate also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models .

HY-122894

Ch-319	Drug Derivative Androgen Receptor Akt Apoptosis	Cancer
Ch-319 is a Triphenyltin (IV) carboxylate derivative. Ch-319 reduces androgen receptor expression, AKT and PRAS40 phosphorylation levels, and increases *FOXO3a* expression. Ch-319 increases Apoptosis. Ch-319 can be used in the research of prostate cancer .

HY-162050

8AQ−Cu−5Iu	Sirtuin	Neurological Disease
8AQ?Cu?5Iu is an activator of SIRT1. 8AQ?Cu?5Iu exhibits neuroprotective effects by modulating the *SIRT1/3-FOXO3a* signaling pathway. 8AQ?Cu?5Iu can used in study attenuating neurodegenerative diseases .

HY-116604

RLX PD 139530	PI3K Akt	Cancer
RLX (PD 139530) is a *PI3K/Akt/FoxO3a* signaling inhibitor, possessing significant therapeutic potential in experimental colon cancer. RLX can effectively modulate the tumor microenvironment, enhancing the efficacy of cancer immunotherapy. RLX demonstrates the ability to improve the retention time of therapeutic agents within the tumor microenvironment by utilizing advanced nanoparticle delivery systems. RLX can be integrated with various treatment modalities, such as chemotherapy and radiotherapy, to enhance overall tumor therapy effectiveness .

HY-116604A

RLX hydrochloride PD 139530 hydrochloride	PI3K Akt	Cancer
RLX (PD 139530) hydrochloride is the hydrochloride of RLX (HY-116604). RLX is a *PI3K/Akt/FoxO3a* signaling inhibitor, possessing significant therapeutic potential in experimental colon cancer. RLX can effectively modulate the tumor microenvironment, enhancing the efficacy of cancer immunotherapy. RLX demonstrates the ability to improve the retention time of therapeutic agents within the tumor microenvironment by utilizing advanced nanoparticle delivery systems. RLX can be integrated with various treatment modalities, such as chemotherapy and radiotherapy, to enhance overall tumor therapy effectiveness .

HY-RS16632

Foxo3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Foxo3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Foxo3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Foxo3 Mouse Pre-designed siRNA Set A Foxo3 Mouse Pre-designed siRNA Set A

HY-RS23067

Foxo3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Foxo3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Foxo3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Foxo3 Rat Pre-designed siRNA Set A Foxo3 Rat Pre-designed siRNA Set A

Butein 5+ Cited Publications 2’,3,4,4’-tetrahydroxy Chalcone	Chalcones Flavonoids other families Classification of Application Fields Anti-aging Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a ^[3]. Butein is a SIRT1 activator (STAC).

Crebanine 4 Publications Verification	Cardiovascular Disease Structural Classification Alkaloids Stephania venosa Classification of Application Fields Other Alkaloids Plants Menispermaceae Inflammation/Immunology Disease Research Fields	Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial
Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC₅₀ of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the *AKT/FoxO3a, NF-κB* and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na ⁺ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease ^[3] .

Butein (Standard) 2’,3,4,4’-tetrahydroxy Chalcone (Standard)	Structural Classification Chalcones Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a ^[3]. Butein is a SIRT1 activator (STAC).

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701170

	FOXO3 Protein, Human (HEK293, His) AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3a	Human	HEK293
	The FOXO3 protein is a multifaceted transcriptional activator that regulates apoptosis, autophagy, and post-transcriptional MYC control. It actively regulates autophagy in skeletal muscle and induces autophagy gene expression under starvation conditions. FOXO3 Protein, Human (HEK293, His) is the recombinant human-derived FOXO3 protein, expressed by HEK293 , with C-10*His labeled tag.

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Host:	Rabbit (7)
Reactivity:	Human (7) Rat (4) Mouse (5)
Application:	IHC-P (2) ICC/IF (2) WB (7) FC (1) ELISA (1)
Isotype:	IgG (6) IgG,IgG/Kappa (1)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (4) Recombinant (3)
Modification:	Phosphorylated (3) Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86548

	*Phospho-FOXO3A(Ser253) Antibody (YA6240)* FOXO3; FKHRL1; FOXO3a; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Phospho-FOXO3A(Ser253) Antibody (YA6240) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-FOXO3A(Ser253).

HY-P80677

	FOXO3A Antibody (YA428) FOXO3; FKHRL1; FOXO3a; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1	WB	Human
	FOXO3A Antibody (YA428) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO3A.

HY-P80677A

	FOXO3A Antibody (YA428)(PBS only) FOXO3; FKHRL1; FOXO3a; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1	WB	Human
	FOXO3A Antibody (YA428) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO3A.

HY-P80817

	*Phospho-FOXO3A* (Ser253) Antibody (YA197)** FOXO3; FKHRL1; FOXO3a; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1	WB	Human, Mouse, Rat
	Phospho-FOXO3A (Ser253) Antibody (YA197) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-FOXO3A (Ser253).

HY-P80817A

	*Phospho-FOXO3A* (Ser253) Antibody (YA197)(PBS only)** FOXO3; FKHRL1; FOXO3a; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1	WB	Human, Mouse, Rat
	Phospho-FOXO3A (Ser253) Antibody (YA197) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-FOXO3A (Ser253).

HY-P810550

	*Phospho-FOXO1A (Thr24)+ FOXO3A* (Thr32)+ FOXO4 (Thr28)+ FOXO6 (Thr26) Antibody (YA9819)** FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, ICC/IF, FC	Human, Mouse
	Phospho-FOXO1A (Thr24)+ FOXO3A (Thr32)+ FOXO4 (Thr28)+ FOXO6 (Thr26) Antibody (YA9819) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-FOXO1A (Thr24)+ FOXO3A (Thr32)+ FOXO4 (Thr28)+ FOXO6 (Thr26).

HY-P80461

	*Phospho-FOXO3A(Ser253) Antibody (YA196)*	WB, IHC-P	Human, Mouse, Rat
	Phospho-FOXO3A(Ser253) Antibody (YA196) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-FOXO3A(Ser253).