Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
FTD
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "FTD" in MCE Product Catalog:
4
Research Areas:
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA .
1
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P74618A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GRN; Glycoprotein 88; Granulin Precursor; GP88; Progranulin; PEPI; PCDGF; Epithelin Precursor; PGRN; Granulin-Epithelin; Proepithelin; Epithelin; Acrogranin; Granulins; CLN11; FTD2; PC Cell-Derived Growth Factor; GEP; Glycoprotein Of 88 Kda
Species:
Human
Source:
HEK293
Cat. No.: HY-NP0204
Synonyms: Mouse Serum Albumin
Target:
Research Areas:
PGN36 is a selective cannabinoid CB2 receptor (CB2R) antagonist with Kis of 0.09 µM and >40 µM for CB2R and CB1R, respectively. PGN36 abolishes the increase in collagen type I gene expression by the inducer of bone activity. PGN36 is able to cross the blood-brain barrier. PGN36 can be used for the study of frontotemporal dementia (FTD) .
Cat. No.: HY-141878
CAS No.: 2767983-76-4
Target:
Research Areas:
di-Ellipticine-RIBOTAC is a RNase recruiting chimera (RIBOTAC) degrader, capable of specifically binding and degrading expanded G4C2 RNA repeat (r(G4C2) exp). di-Ellipticine-RIBOTAC selectively binds the three-dimensional (3D) structure formed by r(G4C2) exp and that recruits an endogenous ribonuclease (RNase) to cleave r(G4C2) exp. di-Ellipticine-RIBOTAC selectively degrades the mutant chromosome 9 open reading frame 72 (C9orf72) allele and reduces quantities of toxic dipeptide repeat proteins (DPRs) translated from r(G4C2) exp. di-Ellipticine-RIBOTAC significantly improves the pathological phenotype of amyotrophic lateral sclerosis/ frontotemporal dementia (c9ALS/FTD) in cells and mouse models. di-Ellipticine-RIBOTAC can be used for the study of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) .
Cat. No.: HY-W141374
CAS No.: 108883-90-5
Target:
Research Areas:
CB096 is an r(G4C2) exp RNA binder with EC50 values of 19 μM, 20 μM and 33 μM. CB096 selectively interacts with the 5′CGG/3′GGC 1×1 GG internal loop motif of folded r(G4C2) exp RNA, alters motif dynamics and closed base pairs, and rescues disease-related pathways. CB096 can be used for research on inherited amyotrophic lateral sclerosis/frontotemporal dementia (c9ALS/FTD) .
Cat. No.: HY-175340
CAS No.: 1361107-81-4
Target:
Research Areas:
Kv7.2/Kv7.3 activator-3 (GRT-X) is an orally active Kv7.2/Kv7.3 and TSPO activator. Kv7.2/Kv7.3 activator-3 activates Kv7.2/Kv7.3, Kv7.4, and Kv7.5 with EC50 values of 0.37, 2.06, and 0.75 μM, respectively, and binds to TSPO with Ki values of 0.07 μM (rat membrane) and 4.60 μM (human U-118 MG cells). Kv7.2/Kv7.3 activator-3 prevents motor neuron degeneration in mice and humans conditioned by ALS/FTD astrocytes. Kv7.2/Kv7.3 activator-3 stimulates dorsal root ganglion axonal growth through TSPO and Kv7.2/3 activation. Kv7.2/Kv7.3 activator-3 has anti-epileptic effects in epileptic seizure models. Kv7.2/Kv7.3 activator-3 reduces pain hypersensitivity in patients with diabetic neuropathy, promotes neuronal survival and regeneration after cervical neuropathy in rats, and accelerates the recovery of normal function of sensory and motor neurons .
Cat. No.: HY-141878A
CAS No.: 2767983-77-5
Target:
Research Areas:
di-Ellipticine-RIBOTAC TFA is a RNase recruiting chimera (RIBOTAC) degrader, capable of specifically binding and degrading expanded G4C2 RNA repeat (r(G4C2) exp). di-Ellipticine-RIBOTAC TFA selectively binds the three-dimensional (3D) structure formed by r(G4C2) exp and that recruits an endogenous ribonuclease (RNase) to cleave r(G4C2) exp. di-Ellipticine-RIBOTAC TFA selectively degrades the mutant chromosome 9 open reading frame 72 (C9orf72) allele and reduces quantities of toxic dipeptide repeat proteins (DPRs) translated from r(G4C2) exp. di-Ellipticine-RIBOTAC TFA significantly improves the pathological phenotype of amyotrophic lateral sclerosis/ frontotemporal dementia (c9ALS/FTD) in cells and mouse models. di-Ellipticine-RIBOTAC TFA can be used for the study of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) .
Cat. No.: HY-172902
CAS No.: 3105281-39-5
Target:
Research Areas:
RNA binder 1 (Compound 4b) is a blood-brain permeable RNA binder. RNA binder 1 can selectively bind to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. RNA binder 1 significantly reduces the levels of toxic polypeptides poly(GA) and poly(GP) produced by the G4C2 repeat sequence in amyotrophic lateral sclerosis (ALS) patient-derived cells. RNA binder 1 has no significant effect on the antisense polypeptide poly(PR), showing selectivity for sense RNA. RNA binder 1 can be used in the study of ALS and frontotemporal dementia (FTD) .
Cat. No.: HY-P78302
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GRN; Glycoprotein 88; Granulin Precursor; GP88; Progranulin; PEPI; PCDGF; Epithelin Precursor; PGRN; Granulin-Epithelin; Proepithelin; Epithelin; Acrogranin; Granulins; CLN11; FTD2; PC Cell-Derived Growth Factor; GEP; Glycoprotein Of 88 Kda
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74618
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GRN; Glycoprotein 88; Granulin Precursor; GP88; Progranulin; PEPI; PCDGF; Epithelin Precursor; PGRN; Granulin-Epithelin; Proepithelin; Epithelin; Acrogranin; Granulins; CLN11; FTD2; PC Cell-Derived Growth Factor; GEP; Glycoprotein Of 88 Kda
Species:
Human
Source:
HEK293
Cat. No.: HY-P704907
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; Tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein Tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-Tau; PPP1R103; MGC138549; Tau-PHF6; FLJ31424; FTDP-17; PHF-Tau; Tau-40; Microtubule-Associated Protein Tau, Isoform 4; MTBT2; Mutant Microtubule-Associated Protein Tau; PPND; Microtubule-Associated Protein; MSTD; FTD1; Tau; TAU; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Microtubule Associated Protein Tau; Protein Phosphatase 1, Regulatory Subunit 103
Species:
Human
Source:
E. coli
Cat. No.: HY-P704910
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; Tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein Tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-Tau; PPP1R103; MGC138549; Tau-PHF6; FLJ31424; FTDP-17; PHF-Tau; Tau-40; Microtubule-Associated Protein Tau, Isoform 4; MTBT2; Mutant Microtubule-Associated Protein Tau; PPND; Microtubule-Associated Protein; MSTD; FTD1; Tau; TAU; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Microtubule Associated Protein Tau; Protein Phosphatase 1, Regulatory Subunit 103
Species:
Human
Source:
E. coli
Cat. No.: HY-P706266
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ¹⁵N-FTDP-17; ¹⁵N-TAU; ¹⁵N-tau-40; ¹⁵N-MAPT; ¹⁵N-microtubule associated protein tau; MAPT; Tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein Tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-Tau; PPP1R103; MGC138549; Tau-PHF6; FLJ31424; FTDP-17; PHF-Tau; Tau-40; Microtubule-Associated Protein Tau; Isoform 4; MTBT2; Mutant Microtubule-Associated Protein Tau; PPND; Microtubule-Associated Protein; MSTD; FTD1; Tau; TAU; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Microtubule Associated Protein Tau; Protein Phosphatase 1; Regulatory Subunit 103
Species:
Human
Source:
E. coli
Cat. No.: HY-P706267
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ¹⁵N,¹³C-FTDP-17; ¹⁵N,¹³C-TAU; ¹⁵N,¹³C-tau-40; ¹⁵N,¹³C-MAPT; ¹⁵N,¹³C-microtubule associated protein tau; MAPT; Tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein Tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-Tau; PPP1R103; MGC138549; Tau-PHF6; FLJ31424; FTDP-17; PHF-Tau; Tau-40; Microtubule-Associated Protein Tau; Isoform 4; MTBT2; Mutant Microtubule-Associated Protein Tau; PPND; Microtubule-Associated Protein; MSTD; FTD1; Tau; TAU; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Microtubule Associated Protein Tau; Protein Phosphatase 1; Regulatory Subunit 103
Species:
Human
Source:
E. coli
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
