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Results for "

Glycyrrhiza

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (4) Aldose Reductase (3) Amyloid-β (4) Antibiotic (1) Apoptosis (8) Autophagy (3) Bacterial (14) Bcl-2 Family (1) Beta-secretase (1) Biochemical Assay Reagents (2) Caspase (3) CCR (2) COX (4) Cytochrome P450 (1) Dengue Virus (1) Drug Derivative (6) Drug Intermediate (1) Endogenous Metabolite (4) ERK (1) Estrogen Receptor/ERR (2) Factor Xa (1) FOXO (1) FXR (1) Glycosidase (1) Influenza Virus (3) Interleukin Related (1) Isotope-Labeled Compounds (1) JNK (1) Keap1-Nrf2 (1) MMP (1) mTOR (1) NF-κB (5) NO Synthase (1) NOD-like Receptor (NLR) (3) p38 MAPK (1) Parasite (3) Phosphatase (3) PI3K (2) PPAR (3) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (9) Reference Standards (10) SOD (1) Topoisomerase (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (3) Endocrinology (2) Infection (18) Inflammation/Immunology (28) Metabolic Disease (10) Neurological Disease (11)

By Targets:

Akt (4)

Aldose Reductase (3)

Amyloid-β (4)

Antibiotic (1)

Apoptosis (8)

Autophagy (3)

Bacterial (14)

Bcl-2 Family (1)

Beta-secretase (1)

Biochemical Assay Reagents (2)

Caspase (3)

CCR (2)

COX (4)

Cytochrome P450 (1)

Dengue Virus (1)

Drug Derivative (6)

Drug Intermediate (1)

Endogenous Metabolite (4)

ERK (1)

Estrogen Receptor/ERR (2)

Factor Xa (1)

FOXO (1)

FXR (1)

Glycosidase (1)

Influenza Virus (3)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

JNK (1)

Keap1-Nrf2 (1)

MMP (1)

mTOR (1)

NF-κB (5)

NO Synthase (1)

NOD-like Receptor (NLR) (3)

p38 MAPK (1)

Parasite (3)

Phosphatase (3)

PI3K (2)

PPAR (3)

Prostaglandin Receptor (1)

Reactive Oxygen Species (ROS) (9)

Reference Standards (10)

SOD (1)

Topoisomerase (1)

By Research Areas:

Cancer (18)

Cardiovascular Disease (3)

Endocrinology (2)

Infection (18)

Inflammation/Immunology (28)

Metabolic Disease (10)

Neurological Disease (11)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0376

Liquiritin 10+ Cited Publications	Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-N0180

18β-Glycyrrhetinic acid 10+ Cited Publications	Endogenous Metabolite	Inflammation/Immunology Cancer
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

HY-N0377

Liquiritigenin 10+ Cited Publications 4',7-Dihydroxyflavanone	Estrogen Receptor/ERR	Neurological Disease Inflammation/Immunology Cancer
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

HY-N0102

Isoliquiritigenin Maximum Cited Publications 31 Publications Verification GU17; ISL; Isoliquiritigen; SJ000286237	Aldose Reductase Influenza Virus Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC₅₀ of 24.7 μM.

HY-N0393

Glabridin 10+ Cited Publications	PPAR Reactive Oxygen Species (ROS) Bacterial	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC₅₀ of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .

HY-N4187

Licochalcone D 5 Publications Verification	NF-κB Apoptosis Reactive Oxygen Species (ROS)	Metabolic Disease Inflammation/Immunology Cancer
Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties .

HY-N0373

Licochalcone B 10+ Cited Publications	Amyloid-β Apoptosis NOD-like Receptor (NLR)	Neurological Disease
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .

HY-N2609

7,4'-Dihydroxyflavone 4 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-121054

Chalcone 1 Publications Verification (E/Z)-Benzylideneacetophenone	Bacterial Parasite	Inflammation/Immunology Cancer
Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities .

HY-N3387

Licoricidin	Apoptosis NF-κB Akt MMP	Inflammation/Immunology Cancer
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

HY-N2123

Neoliquiritin 1 Publications Verification	Caspase	Neurological Disease Cancer
Neoliquiritin is a flavonoid and flavanone-derived cytotoxic agent with anticancer activity and neuroprotective effects. Neoliquiritin exhibits excellent tumor specificity, exerting a more pronounced killing effect on cancer cells compared with normal oral cells. Neoliquiritin also exerts neuroprotective effects by inhibiting ATP depletion and the elevation of caspase 3/7 activity. Widely present in the roots of Glycyrrhiza uralensis, Glycyrrhiza inflata and Glycyrrhiza glabra, Neoliquiritin can be applied to studies on human oral squamous cell carcinoma, leukemia, Parkinson's disease and other conditions .

HY-N6980

Licorice glycoside C2 1 Publications Verification	Others	Others
Licorice glycoside C2 is an acylated flavonoid glycoside found in the underground part of Glycyrrhiza uralensis .

HY-154795

Magnesium isoglycyrrhizinate hydrate	Caspase NOD-like Receptor (NLR)	Inflammation/Immunology
Magnesium isoglycyrrhizinate hydrate is the active component found in licorice plant (Glycyrrhiza glabra). Magnesium isoglycyrrhizinate hydrate exhibits anti-inflammatory activity through NLRP3 inflammasome pathway, and attenuates the chronic obstructive pulmonary disease in rats .

HY-N4194

Glabrone 1 Publications Verification	PPAR Influenza Virus	Infection Metabolic Disease
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .

HY-N6987

Licraside	FXR Factor Xa	Cardiovascular Disease Inflammation/Immunology
Licraside, found in Glycyrrhiza glabra, is a Farnesoid X receptor (FXR) activator. Licraside activates FXR to induce upregulation of SHP and BSEP, regulates bile acid homeostasis, reduces elevated biliary and serum TBA, serum ALT, AST, GGT, ALP, and TBIL levels, and attenuates liver histopathological damage. Licraside inhibits factor Xa with an IC₅₀ of 48.54 mM. Licraside can be used for the research of cholestasis and thromboembolic diseases .

HY-N6911

Licorice-saponin H2 (18β,20α)-Glycyrrhizic acid	Others	Metabolic Disease
Liquorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a type of triterpenoid oligosaccharide glycoside found in the Glycyrrhiza genus. Liquorice-saponin H2 accumulates more in the roots of licorice plants under salt stress conditions, suggesting that it may play a role in plant stress resistance .

HY-N2122

Neoisoliquiritin Neoisoliquiritigenin	Others	Cancer
Neoisoliquiritin is a bioactive component isolated from Glycyrrhiza uralensis .

HY-N4182

Licochalcone E 4 Publications Verification	Akt p38 MAPK Autophagy	Inflammation/Immunology
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation .

HY-N4185

Licoflavone A 3 Publications Verification	Phosphatase	Neurological Disease
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC₅₀ of 54.5 μM .

HY-N3961

Neoglycyrol	Others	Cardiovascular Disease
Neoglycyrol is isolated from the root of Glycyrrhiza uralensis Fisch . Neoglycyrol is a potential myocardial protection active compound screened from traditional patent medicine Tongmai Yangxin pill (TMYXP) .

HY-N0180R

18β-Glycyrrhetinic acid (Standard)	Reference Standards Endogenous Metabolite	Inflammation/Immunology Cancer
18β-Glycyrrhetinic acid (Standard) is the analytical standard of 18β-Glycyrrhetinic acid. This product is intended for research and analytical applications. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

HY-N1280

Semilicoisoflavone B	Amyloid-β	Neurological Disease
Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation .

HY-N0393R

Glabridin (Standard) 10+ Cited Publications	Reference Standards PPAR Reactive Oxygen Species (ROS) Bacterial	Infection Inflammation/Immunology Cancer
Glabridin (Standard) is the analytical standard of Glabridin. This product is intended for research and analytical applications. Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC₅₀ of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .

HY-N9919

Glyasperin C	Others	Others
Glyasperin C is a potent and reversible noncompetitive inhibitor of neuraminidase with an IC₅₀ of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis .

HY-N3920

Gancaonin G	Bacterial	Infection
Gancaonin G is a 6-prenylated isoflavanone that can be isolated from Glycyrrhiza uralensis. Gancaonin G has antibacterial activity against Streptococcus mutants and MRSA strains .

HY-N6583

Licoflavonol 2 Publications Verification	Bacterial	Infection
Licoflavonol, a minor flavone from the roots of Glycyrrhiza uralensis, is an inhibitor of the Salmonella type III secretion system (T3SS) .

HY-N4184

Licoflavone B	Parasite	Infection
Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni ATPase (IC₅₀, 23.78 µM) and ADPase (IC₅₀, 31.50 µM) activity. Anti-schistosomiasis activity .

HY-N6851

Glycyrrhetic acid 3-O-β-D-glucuronide Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid	Others	Inflammation/Immunology
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

HY-N10144

Shinpterocarpin	PI3K Akt Keap1-Nrf2 Bcl-2 Family SOD Reactive Oxygen Species (ROS)	Inflammation/Immunology
Shinpterocarpin is a flavonoid compound. Shinpterocarpin can be isolated from the air-dried roots of Glycyrrhiza glabra L. and Xuanshen Decoction. Shinpterocarpin binds to the targets PI3K, AKT, Nrf2, Bcl-2, Bax, CAT and SOD. Shinpterocarpin enhances immunity and exerts antioxidant effects by reducing the production of ROS .

HY-N1093

(-)-Vestitol (3R)-Vestitol	Others	Others
(-)-Vestitol is a compound isolated from Glycyrrhiza pallidiflora (Leguminosae) .

HY-N6984

Glycyroside	Others	Metabolic Disease
Glycyroside is a isoflavone diglycoside isolated from Glycyrrhiza eurycarpa P. C. Li .

HY-N11111

Glycyrrhizin-6'-methylester	Others	Others
Glycyrrhizin-6'-methylester is a natural product that can be isolated from licorice (Glycyrrhiza glabra) .

HY-N7372

Licoisoflavanone	Apoptosis	Infection Inflammation/Immunology
Licoisoflavanone is an orally active isoflavane-based immunomodulator with multiple activities including antiviral, anti-inflammatory, cytoprotective and cancer cell apoptosis-inducing effects. Licoisoflavanone can be isolated from the roots and rhizomes of Glycyrrhiza uralensis Fisch. Licoisoflavanone not only enhances the body's immunity, but also effectively prevents acute respiratory distress syndrome and multiple organ damage by alleviating cytokine storm, thereby reducing the degree of inflammation. In rats, Licoisoflavanone undergoes multiple metabolic transformation processes such as glucuronidation, hydroxylation, sulfation, methylation and dehydrogenation. Licoisoflavanone has become an important candidate molecule for research on COVID-19 and related inflammatory diseases .

HY-N6986

Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside Liquiritigenin-7-apiosylglucoside	Others	Cancer
Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside (Liquiritigenin-7-apiosylglucoside) is a flavonoid isolated from the roots of Glycyrrhiza, has weaker cytotoxicity against several tumor cells and normal cells .

HY-N11026

22-Beta-Acetoxyglycyrrhizin	Others	Others
22-Beta-Acetoxyglycyrrhizin is a triterpene glucuronide that can be isolated from the roots of Glycyrrhiza .

HY-N8610

Uralsaponin D	Phosphatase	Inflammation/Immunology
Uralsaponin D is a saponin that can be isolated from Glycyrrhiza inflata. Uralsaponin D inhibits phospholipase A2 (PLA₂) with an IC₅₀ value of 32.2 μM .

HY-N1230

Sophoraisoflavone A Allolicoisoflavone B	Phosphatase	Inflammation/Immunology
Sophoraisoflavone A (Allolicoisoflavone B) is a nature product that could be isolated from Glycyrrhiza inflate. Sophoraisoflavone A is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ value of 0.80 μM. Sophoraisoflavone A can be used in research of inflammation .

HY-N3922

Gancaonin M	Others	Others
Gancaonin M is a Flavonoids product that can be isolated from the roots of Glycyrrhiza uralensis Fisch .

HY-N10133

Licoflavanone 3′-Prenylnaringenin	Bacterial mTOR Akt PI3K NF-κB Caspase JNK ERK COX NO Synthase Apoptosis	Others
Licoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra. Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax, Bad and multiple caspase enzymes to induce apoptosis. Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB, decreasing the phosphorylation levels of p38, JNK and ERK1/2, thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS. Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms .

HY-N8656

Glycyrrhiza-flavonol A	Others	Others
Glycyrrhiza-flavonol A (compound 4) is a natural product of Glycyrrhiza, Fabaceae .

HY-N8609

Uralsaponin C	Others	Others
Uralsaponin C is an analogue of oleanane-type triterpenoid saponin. Uralsaponin C can be isolated from the roots of Glycyrrhiza uralensis Fisch .

HY-N3947

Glepidotin B	Bacterial	Infection
Glepidotin B is a dihydroflavonol compound isolated from the extracts of American licorice, Glycyrrhiza lepidota (Leguminosae). Glepidotin B is an antimicrobial agent .

HY-N13264

Glyuranolide	Drug Derivative	Others
Glyuranolide is a chemical component that can be extracted from Glycyrrhiza uralensis Fisch. Glyuranolide is a triterpenoid compound. Glyuranolide is a potential anti-tumor agent .

HY-N0102R

Isoliquiritigenin (Standard) GU17 (Standard); ISL (Standard); Isoliquiritigen (Standard); SJ000286237 (Standard)	Reference Standards Aldose Reductase Influenza Virus Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Isoliquiritigenin (Standard) is the analytical standard of Isoliquiritigenin. This product is intended for research and analytical applications. Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.

HY-N2609R

7,4'-Dihydroxyflavone (Standard)	COX Reference Standards CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .

HY-N6911B

Licorice-saponin H2 ammonium (18β,20α)-Glycyrrhizic acid ammonium	Others	Metabolic Disease
Liquorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) ammonium is a type of triterpenoid oligosaccharide glycoside found in the Glycyrrhiza genus. Liquorice-saponin H2 ammonium accumulates more in the roots of licorice plants under salt stress conditions, suggesting that it may play a role in plant stress resistance .

HY-108421

Xinjiachalcone A	Bacterial	Infection
Xinjiachalcone A is an active principle of Glycyrrhiza inflata Batalin. Xinjiachalcone A shows both a low MIC and a strong bactericidal activity against H. pylori, with MIC values ranged from 12.5 to 50 µM for seventeen H. pylori strains .

HY-N0376R

Liquiritin (Standard)	Reference Standards Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-142096

Glycyuralin E	Others	Others
Glycyuralin E is a natural product that can be isolated from Glycyrrhiza uralensis .

HY-N8813

Glucoliquiritin	Others	Others
Glucoliquiritin is a Flavonoids product that can be isolated from the roots of Glycyrrhiza glabra L. .

Cat. No.	Product Name	Category	Target	Chemical Structure