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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
HPTP
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "HPTP" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: AKB-9778
Target:
Forschungsgebiete:
Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM) .
4
Target:
Forschungsgebiete:
Razuprotafib (AKB-9778) sodium is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib sodium promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib sodium inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib sodium shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM) .
1
1 Cited Publications
Art. -Nr.: HY-N2451
CAS. Nr.: 33037-46-6
Category:
Quinones Plant Monophenols Aloe vera (L.) Burm. f. Extract Anthraquinones Metabolic Disease Phenols Liliaceae Extract Disease Research Fields
Target:
Synonyms: BMOV
Target:
Forschungsgebiete:
Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer .
Art. -Nr.: HY-N0312
CAS. Nr.: 113443-70-2
Category:
Quinones Plant Monophenols Anthraquinones Metabolic Disease Phenols Rheum palmatum L. Extract Disease Research Fields Polygonaceae Extract
Target:
Art. -Nr.: HY-RS11436
Target:
Forschungsgebiete:
PTPRD Human Pre-designed siRNA Set A contains three designed siRNAs for PTPRD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-139641
CAS. Nr.: 724451-35-8
Target:
Forschungsgebiete:
PTP1B-IN-14 is an allosteric, selective PTP1B inhibitor with an IC50 of 0.72 μM against hPTP1B. PTP1B-IN-14 can be used for research on type 2 diabetes and obesity .
Art. -Nr.: HY-N2451R
CAS. Nr.: 33037-46-6
Category:
Quinones Plant Monophenols Aloe vera (L.) Burm. f. Extract Anthraquinones Phenols Liliaceae Extract
Target:
Art. -Nr.: HY-109041R
CAS. Nr.: 1008510-37-9
Synonyms: AKB-9778 (Standard)
Target:
Forschungsgebiete:
Razuprotafib (Standard) is the analytical standard of Razuprotafib (HY-109041). This product is intended for research and analytical applications. Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM) .
Art. -Nr.: HY-P84196A
Synonyms: PTPRD; Receptor-type tyrosine-protein phosphatase delta
Art. -Nr.: HY-P78721
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PTPRD; R-PTP-Delta; Protein Tyrosine Phosphatase Receptor Type D; Protein Tyrosine Phosphatase, Receptor Type, Delta Polypeptide; Receptor-Type Tyrosine-Protein Phosphatase Delta; Protein-Tyrosine Phosphatase Delta; PTPD; HPTPDELTA; HPTP; RPTPDELTA; Rcept
Species:
Human
Source:
HEK293
Art. -Nr.: HY-N20734
CAS. Nr.: 64527-08-8
Synonyms: Polygalacin
Target:
Art. -Nr.: HY-P87416A
Synonyms: CD148; DEP1; PTPRJ; Receptor-type tyrosine-protein phosphatase eta; Protein-tyrosine phosphatase eta; R-PTP-eta; Density-enhanced phosphatase 1; HPTP eta; Protein-tyrosine phosphatase receptor type J; DEP-1; R-PTP-J
Art. -Nr.: HY-P74200
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTPRJ; HPTP Eta; Protein Tyrosine Phosphatase Receptor Type J; R-PTP-J; DEP1; Protein Tyrosine Phosphatase, Receptor Type, J Polypeptide; Receptor-Type Tyrosine-Protein Phosphatase Eta; Susceptibility To Colon Cancer 1, Mouse, Homolog Of; HPTPeta; Human D
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
