161 Results for "

HSPC

" in MedChemExpress (MCE) Product Catalog:
Products (161)

161 Results for "HSPC" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-P1122
CAS No.: 83602-39-5
Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-P71323
Purity:  ≥85%, as determined by reducing SDS-PAGE.
Synonyms: SMAD3; MAD, Mothers Against Decapentaplegic Homolog 3; Prev. MADH3; SMAD, Mothers Against DPP Homolog 3; JV15-2; SMA- And MAD-Related Protein 3; HsT17436; Mothers Against DPP Homolog; Mothers Against Decapentaplegic Homolog 3; Mad Protein Homolog; Mothers Against DPP Homolog 3; Mad Homolog JV15-2; MAD Homolog 3; SMAD Family Member; HMAD-3; MAD Homolog; HSMAD3; HSPC193; Mad3; SMAD 3; MAD, Mothers Against Decapentaplegic Homolog 3 (Drosophila); LDS1C; SMAD, Mothers Against DPP Homolog 3 (Drosophila); LDS3; SMAD Family Member 3; Mothers Against Decapentaplegic Homolog
Species:  
Human
Source:  
E. coli
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-P0172
CAS No.: 1337878-62-2
Target:  

CXCR

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-P0172A
Target:  

CXCR

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-P72238
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSP90AA1; Heat Shock 86 KDa; Prev. HSPC1; FLJ31884; Prev. HSPCA; HSP90A; Prev. HSPCAL4; HSP 86; HSP90N; HSP86; Hsp89; LAP-2; Hsp90; Heat Shock Protein 90kDa Alpha Family Class A Member 1; Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1; Heat
Species:  
Human
Source:  
E. coli
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-107589
CAS No.: 327613-57-0
Purity:  99.96%
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P1682A
Synonyms: POL6326 TFA
Target:  

CXCR Arrestin

Research Areas:  

Cancer

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-19867A
CAS No.: 1191450-19-7
Synonyms: TG-0054 hydrobromide
Target:  

CXCR

Research Areas:  

Cardiovascular Disease Cancer

Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. Burixafor hydrobromide inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34 + hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood. Burixafor hydrobromide can be used for research on autologous hematopoietic stem cell transplantation (ASCT) .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P1682
CAS No.: 1051366-32-5
Synonyms: POL6326
Target:  

CXCR Arrestin

Research Areas:  

Cancer

Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-107589A
Purity:  99.96%
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels .
loading...
    loading...
Cat. No.: HY-42990
CAS No.: 97281-48-6
Synonyms: HSPC; Hydrogenated soybean phosphatidylcholine
Target:  

Liposome

Research Areas:  

Metabolic Disease

Hydrogenated soya phosphatidylcholine (hydrogenated soybean phosphatidylcholine) is a natural product. Hydrogenated soya phosphatidylcholine can extend drug release in regard to drug loading and solubility for oral drug delivery of watersoluble drugs .
loading...
    loading...
Cat. No.: HY-RS11297
Research Areas:  

Others

PSMA7 Human Pre-designed siRNA Set A contains three designed siRNAs for PSMA7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-139938
CAS No.: 90693-45-1
Synonyms: 11,12-EET methyl ester; (±)11,12-EpETrE methyl ester
(±)11(12)-EET methyl ester (11,12-EET-methyl ester) is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±)11(12)-EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±)11(12)-EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±)11(12)-EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis .
loading...
    loading...
Cat. No.: HY-139938S
Synonyms: 11,12-EET methyl ester-d11; (±)11,12-EpETrE methyl ester-d11
(±)11(12)-EET-d11 methyl ester (11,12-EET methyl ester-d11) is the deuterium labeled (±)11(12)-EET methyl ester (HY-139938). (±)11(12)-EET methyl ester (11,12-EET-methyl ester) is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±)11(12)-EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±)11(12)-EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±)11(12)-EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis .
loading...
    loading...
Cat. No.: HY-P88801
Synonyms: HSPC045; HSPC226; NYD-SP6

Host:  

Mouse

Application:  

IHC-P, ICC/IF, FC

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P88801A
Synonyms: HSPC045; HSPC226; NYD-SP6

Host:  

Mouse

Application:  

IHC-P, ICC/IF, FC

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P810985
Synonyms: HSPC206, HSPC232, PPHLN1, Periphilin-1, CDC7 expression repressor, Gastric cancer antigen Ga50, CR

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-P82602
Synonyms: NEDSG; HSPC155

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-P87237
Synonyms: C6 antibody

Host:  

Rabbit

Application:  

WB, ICC/IF, IHC-P, FC

Reactivity:  

Human, Mouse, Rat, Monkey

loading...
    loading...
Cat. No.: HY-P88568
Synonyms: HSPC182; PNAS-120

Host:  

Mouse

Application:  

IHC-P

Reactivity:  

Human, Mouse, Rat

loading...
    loading...