143 Results for "

HSPC

" in MedChemExpress (MCE) Product Catalog:
Products (143)

143 Results for "HSPC" in MCE Product Catalog:

6
6 Publications Verification
Cat. No.: HY-101395A
CAS No.: 909725-62-8
Purity:  98.22%
Target:  

LPL Receptor Apoptosis

Research Areas:  

Metabolic Disease Cancer

W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-P1122
CAS No.: 83602-39-5
Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-P0172
CAS No.: 1337878-62-2
Target:  

CXCR

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-P0172A
Target:  

CXCR

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-P72238
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Heat shock 86 kDa; Heat shock protein 90kDa alpha cytosolic class A member 1; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein HSP 90 alpha ; Heat shock protein HSP 90 beta; Heat shock protein HSP 90-alpha; HS90A_HUMAN; HSP 84; HSP 86; Hsp 90; HSP86; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSPC1; HSPC2; HSPCAL1 ; HSPCAL4; Renal carcinoma antigen NY-REN-38
Species:  
Source:  
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-107589
CAS No.: 327613-57-0
Purity:  99.96%
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-19867A
CAS No.: 1191450-19-7
Synonyms: TG-0054 hydrobromide
Target:  

CXCR

Research Areas:  

Cardiovascular Disease Cancer

Burixafor (TG-0054) hydrobromide is a potent CXCR4 antagonist with a pIC50 of 7.4. Burixafor hydrobromide inhibits the binding of CXCL12 to CXCR4, antagonizes CXCL12-induced recruitment of Gαᵢ and β-arrestin2, and blocks the downstream Gαᵢ-mediated inhibitory effect on cAMP signal transduction. Burixafor hydrobromide mobilizes CD34 + hematopoietic stem/progenitor cells (HSPC) from the bone marrow to the peripheral blood. Burixafor hydrobromide can be used for research on autologous hematopoietic stem cell transplantation (ASCT) .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-107589A
Purity:  99.96%
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P1682A
Synonyms: POL6326 TFA
Target:  

CXCR Arrestin

Research Areas:  

Cancer

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P1682
CAS No.: 1051366-32-5
Synonyms: POL6326
Target:  

CXCR Arrestin

Research Areas:  

Cancer

Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P703226
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GRP94; HSPC4; TRA1
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-42990
CAS No.: 97281-48-6
Synonyms: HSPC; Hydrogenated soybean phosphatidylcholine
Hydrogenated soya phosphatidylcholine (hydrogenated soybean phosphatidylcholine) is a natural product. Hydrogenated soya phosphatidylcholine can extend drug release in regard to drug loading and solubility for oral drug delivery of watersoluble drugs .
loading...
    loading...
Cat. No.: HY-P10999
Synonyms: P55
Research Areas:  

Others

INF7TAT-P55 (P55) is a polypeptide derived from INF7TAT (HY-P11000) with G1K, G20L and Y22N mutations. INF7TAT-P55 serves as a delivery carrier to deliver preassembled CRISPR ribonucleases into cells for genome editing .
loading...
    loading...
Cat. No.: HY-RS11297
Research Areas:  

Others

PSMA7 Human Pre-designed siRNA Set A contains three designed siRNAs for PSMA7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-139938
CAS No.: 90693-45-1
Synonyms: 11,12-EET methyl ester; (±)11,12-EpETrE methyl ester
(±)11(12)-EET methyl ester (11,12-EET-methyl ester) is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±)11(12)-EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±)11(12)-EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±)11(12)-EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis .
loading...
    loading...
Cat. No.: HY-139938S
Synonyms: 11,12-EET methyl ester-d11; (±)11,12-EpETrE methyl ester-d11
(±)11(12)-EET-d11 methyl ester (11,12-EET methyl ester-d11) is the deuterium labeled (±)11(12)-EET methyl ester (HY-139938). (±)11(12)-EET methyl ester (11,12-EET-methyl ester) is a methylated derivative of 11,12-epoxyeicosatrienoic acid (11,12-EET) (HY-130494). (±)11(12)-EET methyl ester cannot induce β-arrestin recruitment of the G protein-coupled receptor GPR132. (±)11(12)-EET methyl ester fails to enhance the expression of hematopoietic stem and progenitor cell (HSPC) markers. (±)11(12)-EET methyl ester can be used as a negative control molecule to study the structure-function relationship of 11,12-EET, facilitating the analysis of the role of the oxygenated fatty acid-GPR132 signaling axis in hematopoiesis .
loading...
    loading...
Cat. No.: HY-P88801
Synonyms: HSPC045; HSPC226; NYD-SP6

Host:  

Mouse

Application:  

IHC-P, ICC/IF, FC

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-101395AR
CAS No.: 909725-62-8
W146 (TFA) (Standard) is the analytical standard of W146 (TFA) (HY-101395A). This product is intended for research and analytical applications. W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
loading...
    loading...
Cat. No.: HY-P703570
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSP90B; HSPC2; HSPC3; HSPCB
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P88801A
Synonyms: HSPC045; HSPC226; NYD-SP6

Host:  

Mouse

Application:  

IHC-P, ICC/IF, FC

Reactivity:  

Human

loading...
    loading...