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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
237 Results for "
HTS
" in MedChemExpress (MCE) Product Catalog:
Products (237)
237 Results for "HTS" in MCE Product Catalog:
24
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LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, and exhibits 7-fold selectivity over TGFβR-II .
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HTS01037 is an inhibitor of fatty acid binding; and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 with a Ki of 0.67 μM.
Synonyms: HTS 09836; NB001
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NB001 (HTS 09836) is an adenylcyclase 1 (AC1) inhibitor which has effect on neural and non-neural pain by modulating AC1 activity .
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(R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. (R)-HTS-3 suppresses the C20:4 content of PE, PC, and PS, while promoting a correspondingelevation in C22:4 phospholipids and a paradoxical increase in C20:4 phosphatidylinositol (PI) lipids .
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HTS07545 is a sulfide:quinone oxidoreductase (SQOR) inhibitor with an IC50 of 30 nM. HTS07545 inhibits SQOR function and mediates resistance to ferroptosis. HTS07545 reduces tumor volume and weight of pancreatic ductal adenocarcinoma. HTS07545 induces tumor cell nuclear necrosis. The combination of HTS07545 and Erastin (HY-15763) exerts a synergistic effect without causing significant weight loss in mice. HTS07545 can be used in studies related to pancreatic ductal adenocarcinoma and heart failure [1] [2].
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PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers .
GSK2200150A, identified by high-throughput screening (HTS) campaign, is an anti-tuberculosis (TB) agent.
Cat. No.: HY-RS00811
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APCDD1 Human Pre-designed siRNA Set A contains three designed siRNAs for APCDD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-137225
CAS No.: 706758-28-3
Synonyms: HTS07944SC
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HTS07944 (HTS07944SC, C3) is a potent modulator of laminin receptor (37 LR). HTS07944 (HTS07944SC, C3) possesses anti-cancer activity in PC-3 cells and activates Caspase 3/7 .
Cat. No.: HY-148600
CAS No.: 727359-12-8
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HTS13286 is a novel AQP9 inhibitor. HTS13286 prevents the LPS-induced increase of NO. HTS13286 reduces glucose output. HTS13286 can be used in the research of endotoxin shock .
C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC90 of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages .
Cat. No.: HY-119266
CAS No.: 91533-02-7
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HTS13517 is a DPP4 inhibitor, with an IC50 of 10.73 μM .
Cat. No.: HY-174842
CAS No.: 696643-14-8
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HTS05585 (Compound Hit-1) is a selective macrophage migration inhibitory factor (MIF) inhibitor with a Kd value of 0.29 μM measured by microscale thermophoresis (MST) and 0.32±0.01 μM verified by isothermal titration calorimetry (ITC). HTS05585 inhibits the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) from LPS-induced macrophages. HTS05585 is promising for research of inflammation-related diseases such as sepsis .
Cat. No.: HY-101503R
CAS No.: 682741-29-3
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HTS01037 (Standard) is the analytical standard of HTS01037 (HY-101503). This product is intended for research and analytical applications. HTS01037 is an inhibitor of fatty acid binding; and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 with a Ki of 0.67 μM.
Cat. No.: HY-179594
CAS No.: 81682-91-9
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HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease .
Cat. No.: HY-158790A
CAS No.: 2771208-82-1
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(S)-HTS-3 is a Lysophosphatidylcholine acyltransferase 3 (LPCAT3/MBOAT5) inhibitor with a human IC50 of 4.1 μM. (S)-HTS-3 inhibits the acyltransferase activity of LPCAT3. (S)-HTS-3 modestly reduces incorporation of deuterated arachidonic acid into C20:4 phosphatidylserine in myeloid leukemia cells .
Cat. No.: HY-184155
CAS No.: 2756347-51-8
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LC1343 is a human thymidylate synthase (hTS) inhibitor with an IC50 of 7 μM. LC1343 inhibits cancer cell growth and induces apoptosis in cancer cells. LC1343 can be used for the research of ovarian cancer, colorectal cancer, and pancreatic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
