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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1138 Results for "
Hyacinthus orientalis L. Sp. Pl.
" in MedChemExpress (MCE) Product Catalog:
Products (1138)
1138 Results for "Hyacinthus orientalis L. Sp. Pl." in MCE Product Catalog:
627
Target:
Research Areas:
SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis .
58
Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression .
19
19 Cited Publications
Target:
13
13 Cited Publications
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SP2509 is a potent and selective antagonist of lysine specific demethylase 1 (LSD1) with an IC50 of 13 nM .
11
11 Cited Publications
Synonyms: SP-2577 mesylate
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Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma .
11
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Seclidemstat is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma .
9
9 Cited Publications
Cat. No.: HY-P70593
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FN1; Epididymis Secretory Sperm Binding Protein; Fibronectin 1; Fibronectin Splice Variant A; CIG; Fibronectin Splice Variant B; Cold-Insoluble Globulin; Fibronectin Splice Variant C; Lnc-ABCA12-8; Fibronectin Splice Variant D; Fibronectin; Fibronectin Sp
Species:
Human
Source:
E. coli
7
7 Cited Publications
Synonyms: Procaine amide hydrochloride; SP 100 hydrochloride
Research Areas:
Procainamide hydrochloride (Procaine amide hydrochloride) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide hydrochloride induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide hydrochloride relaxes airway smooth muscle by activating potassium channels. Procainamide hydrochloride can be used in cancer and arrhythmia research .
7
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Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research .
7
7 Cited Publications
Cat. No.: HY-P70570
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear Dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Human
Source:
E. coli
7
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM .
5
5 Cited Publications
SP-141 is a specific inhibitor of MDM2. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 might be used for the research of pancreatic cancer and breast cancer cells .
5
5 Cited Publications
Cat. No.: HY-P73104
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear Dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Mouse
Source:
HEK293
4
4 Cited Publications
Synonyms: Biafungin acetate; CD101 acetate; SP-3025 acetate
Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
4
4 Cited Publications
Cat. No.: HY-N0805
CAS No.: 26575-95-1
Synonyms: 23-Acetylalismol B; 23-O-Acetylalisol B; Alisol B monoacetate
4
4 Cited Publications
Cat. No.: HY-P73104A
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear Dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Mouse
Source:
HEK293
3
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SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.
3
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Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome .
3
3 Cited Publications
Cat. No.: HY-W013375
CAS No.: 76721-89-6
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Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases .
3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
