38 Results for "

IL4R

" in MedChemExpress (MCE) Product Catalog:
Products (38)

38 Results for "IL4R" in MCE Product Catalog:

8
8 Publications Verification
Cat. No.: HY-P9926
CAS No.: 1190264-60-8
Synonyms: REGN-668; SAR-231893

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis .
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1 Cited Publications
Cat. No.: HY-P99025
CAS No.: 953400-68-5
Synonyms: TNX-650; MILR1444A; RG3637

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases .
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1 Cited Publications
Cat. No.: HY-P7220
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuIL-4R; IL4R; IL-4RA; CD124
Species:  
Source:  
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1 Cited Publications
Cat. No.: HY-P11143A
Research Areas:  

Cancer

IL4RPep-1 acetate is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 acetate preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1 acetate-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1 acetate-labeled liposomes accumulate more effectively within H226 tumors .
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Cat. No.: HY-P990093
CAS No.: 2734715-10-5
Synonyms: CM310

Research Areas:  

Inflammation/Immunology

Stapokibart (CM310) is a humanized monoclonal antibody targeting IL-4Rα (KD values of 0.25 nM, 1.50 nM, and 2.75 nM for human, cynomolgus monkey, and rat IL-4Rα, respectively). Stapokibart effectively blocks the interaction of cytokines IL-4 and IL-13 with their co-receptor subunit IL-4Rα. Stapokibart reduces IL-4 and IL-13 mRNA, inhibits CD23 upregulation, and inhibits IL-4 and IL-13-induced STAT6 activation. Stapokibart improves inflammation (airway inflammation, rhinitis, dermatitis) .
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Cat. No.: HY-P990090
CAS No.: 2648260-80-2
Synonyms: CBP-201

Research Areas:  

Inflammation/Immunology

Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα and IL-4Rα inhibitor with a KD of 20.7 pM when binding to human IL-4Rα epitopes . Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and thymus activation regulated chemokine (TRAC) production. Rademikibart can be used for the research of atopic dermatitis and asthma .
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Cat. No.: HY-P99724
CAS No.: 2428381-56-8
Synonyms: AK120

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Manfidokimab (AK120) is an anti-interleukin 4 receptor alpha (IL-4Rα) IgG4 monoclonal antibody .
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Cat. No.: HY-174603
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human IL4R mRNA encodes the human interleukin 4 receptor (IL4R) protein, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. IL4R also can bind interleukin 4 to promote differentiation of Th2 cells.
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Cat. No.: HY-RS06769
Research Areas:  

Others

IL4R Human Pre-designed siRNA Set A contains three designed siRNAs for IL4R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23551
Research Areas:  

Others

Il4r Rat Pre-designed siRNA Set A contains three designed siRNAs for Il4r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P991515

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

TQH-2722 is a humanized IgG4 anti-IL-4Rα monoclonal antibody. TQH-2722 targets the IL-4Rα receptor in humans, effectively disrupting the interaction between IL-4Rα and the downstream cytokines IL-4 and IL-13, thereby inhibiting inflammatory response. TQH-2722 can be used for the study of atopic dermatitis (AD) and chronic rhinosinusitis with nasal polyps (CRSwNP) .
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Cat. No.: HY-P991283

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

AMG 317 is a humanized monoclonal anti-CD124/IL4R/IL-4Rα antibody. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002). AMG 317 can be used in research related to asthma .
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Cat. No.: HY-P991031
CAS No.: 2618667-96-0
Synonyms: GR-1802

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

HY-P991031 is an IL4R-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P991675
CAS No.: 3031358-44-5

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Camtarkibart is an anti-IL4R IgG4κ type humanized antibody with immunomodulator activity. The recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P991152
CAS No.: 2956767-43-2
Synonyms: QX-005N

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Oturkibart is a humanized immunoglobulin G4-κ monoclonal antibody targeting the human interleukin 4 receptor (IL4R). Oturkibart is promising for research of inflammatory diseases, such as asthma and atopic dermatitis .
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Cat. No.: HY-P11143
CAS No.: 1900734-29-3
Research Areas:  

Cancer

IL4RPep-1 is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1-labeled liposomes accumulate more effectively within H226 tumors .
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Cat. No.: HY-P991285

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

MEDI-9314 is a humanized monoclonal anti-CD124/IL4R/IL-4Rα antibody. MEDI-9314 can be used in research related to skin allergy .
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Cat. No.: HY-P990910
CAS No.: 2833673-47-3
Synonyms: MG-K10

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

HY-P990910 is an IL4R-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Cat. No.: HY-P77010
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-4 receptor subunit alpha; IL4R alpha; IL4R; CD124
Species:  
Source:  
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Cat. No.: HY-P77009
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-4 receptor subunit alpha; IL4R alpha; IL4R; CD124
Species:  
Source:  
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