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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
190 Results for "
IRF
" in MedChemExpress (MCE) Product Catalog:
Products (190)
190 Results for "IRF" in MCE Product Catalog:
42
42 Publications Verification
GSK-690693 is an ATP-competitive pan-Akt inhibitor with IC50s of 2 nM, 13 nM, 9 nM for Akt1, Akt2 and Akt3, respectively. GSK-690693 is also an AMPK inhibitor, affects Unc-51-like autophagy activating kinase 1 (ULK1) activity and robustly inhibits STING-dependent IRF3 activation .
19
19 Cited Publications
Cat. No.: HY-12326A
CAS No.: 2734909-87-4
Synonyms: Cyclic diadenylate disodium; Cyclic-di-AMP disodium
Target:
19
19 Cited Publications
Cat. No.: HY-12326B
Purity: 99.36%
Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium
Target:
7
7 Cited Publications
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Research Areas:
4
4 Cited Publications
Target:
Research Areas:
KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy.
4
4 Cited Publications
Cat. No.: HY-160225
Target:
Research Areas:
ISD sodium is an interferon-stimulatory DNA, a 45 bp non-CpG double-stranded oligonucleotide derived from the genome of Listeria monocytogenes. ISD sodium potently induces type I interferon production via the cGAS‑STING‑TBK1‑IRF3 pathway .
4
4 Cited Publications
ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
4
4 Cited Publications
Cat. No.: HY-P70700A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Stimulator of interferon genes protein; TMEM173; Mediator of IRF3 activation; sting;
3
Target:
Research Areas:
CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively .
2
2 Cited Publications
Target:
Research Areas:
IRF5-IN-1 (Compound C5) is a conformationally locked inhibitor for SLC15A4. IRF5-IN-1 blocks the downstream IRF5 activation, inhibits the TLR7/8 signaling pathway. IRF5-IN-1 exhibits anti-inflammatory responses .
2
2 Cited Publications
Cat. No.: HY-N8107
CAS No.: 34446-06-5
2
2 Cited Publications
Target:
Research Areas:
YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research .
2
1
1 Cited Publications
Cat. No.: HY-171006
CAS No.: 701225-07-2
Target:
Research Areas:
IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1). IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury .
1
1 Cited Publications
Synonyms: 1-Methyl-DL-tryptophan; (Rac)-NLG-8189
Research Areas:
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes .
1
1 Cited Publications
Cat. No.: HY-171007
CAS No.: 708245-32-3
Research Areas:
IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury .
1
1 Cited Publications
SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity .
1
1 Cited Publications
Cat. No.: HY-P70573A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Interferon Regulatory Factor 5; IRF-5; IRF5
1
1 Cited Publications
Cat. No.: HY-P82917
Synonyms: anti-Interferon regulatory factor 6; anti-IRF 6; anti-LPS; anti-OFC 6; anti-PIT; anti-PPS; anti-PPS1; anti-VWS; anti-VWS1; Interferon regulatory factor 6 antibody; IRF 6 antibody; LPS antibody; OFC 6 antibody; PIT antibody; PPS antibody; PPS1 antibody; VWS antibody; VWS1 antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
