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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
IgG-bead incubation
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "IgG-bead incubation" in MCE Product Catalog:
Cat. No.: HY-156820
CAS No.: 3077339-82-0
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HLDA-221 is a non-covalent regulated induced proximity targeting chimeras (RIPTAC). The binding of HLDA-221 to BRD4-BD1 is significantly increased after pre-incubation with FKBP. HLDA-221 can be used in cancer research .
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Arylsulfatase is a hydrolase with substrate specificity for potassium 6-benzoyl-2-naphthyl sulfate. Arylsulfatase exhibits optimal activity at 37°C, and its incubation time is tissue-dependent. Arylsulfatase can be used in tumor-related research .
Cat. No.: HY-137959
CAS No.: 250780-40-6
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Cat. No.: HY-D1632
CAS No.: 460085-45-4
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4-MU-α-GlcNS sodium is a fluorogenic substrate for heparan sulfate sulfamidase, with apparent Km values of 4 mM and 8 mM for fibroblast and leukocyte enzymes, respectively. 4-MU-α-GlcNS sodium undergoes enzymatic desulfation to generate an intermediate, which requires a second incubation with yeast α-glucosidase to hydrolyze and release 4-methylumbelliferone, detected by fluorescence at Ex/Em = 365/450 nm. 4-MU-α-GlcNS sodium is suitable for fibroblast homogenates, leukocytes, and dried leukocyte filter paper samples, and can be used for the detection and study of enzyme activity in mucopolysaccharidosis type IIIA .
Cat. No.: HY-176540
CAS No.: 2699937-76-1
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Microtubule stabilizer-1 (compound 69) is a brain-penetrant microtubule (MT) stabilizer. Microtubule stabilizer-1 increases acetylated α-tubulin (AcTub) levels and prevents the characteristic loss of neuronal MTs that is observed after incubation with Okadaic acid (HY-N6785). Microtubule stabilizer-1 can be used for the study of Alzheimer’s disease (AD) and related neurodegenerative tauopathies .
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Thermostable cellulase recombinant is a cellulose hydrolase present in hyperthermophiles, which catalyzes the hydrolysis of β-1,4 glycosidic bonds in cellulose. Thermostable cellulase recombinant targets carboxymethyl cellulose (CMC) as its primary substrate, and retains high residual activity even after incubation at high temperatures. The activity of Thermostable cellulase recombinant is inhibited by ionic and non-ionic detergents, and can be enhanced by cobalt ions. Thermostable cellulase recombinant can be applied in the paper industry .
Cat. No.: HY-W007704
CAS No.: 4630-82-4
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Cat. No.: HY-130238
CAS No.: 90780-54-4
Synonyms: (±)8-HDoHE; 8-hydroxy Docosahexaenoic acid; (±)8-HDoHE
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(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
Cat. No.: HY-130288
CAS No.: 90780-53-3
Synonyms: (±)13-HDoHE; 13-hydroxy Docosahexaenoic acid; (±)13-HDoHE
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(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra is shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
Cat. No.: HY-W040176
CAS No.: 799268-45-4
Synonyms: N-Palmitoyl-tyrosine phosphoric acid ammonium
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Cardiovascular Disease Neurological Disease Inflammation/Immunology
N-PTyrosine PA (N-Palmitoyl-tyrosine phosphoric acid) ammonium is a lysophosphatidic acid (LPA) receptor modulator, which exhibits weak inhibitory activity against LPA1 and partial agonist properties towards LPA5. N-PTyrosine PA ammonium inhibits the activation of LPA receptors and downstream responses by competing with agonists for binding sites. N-PTyrosine PA ammonium can induce morphological changes and aggregation, and also inhibit LPA-induced morphological changes through receptor desensitization caused by pre-incubation. N-PTyrosine PA ammonium can be used in the research of related diseases such as atherosclerosis and acute ischemic syndromes (e.g., unstable angina, myocardial infarction, stroke) .
Cat. No.: HY-145408
CAS No.: 2747919-19-1
CDK7/9-IN-1 is a cyclin-dependent kinases 7/9 (CDK7/9) inhibitor. CDK7/9-IN-1 selectively inhibits CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. CDK7/9-IN-1 can be used for the research of cancer .
Cat. No.: HY-162599
Category:
Natural Products Hypericaceae Extract Hypericum patulum Thunb. Apiaceae Extract Plants Heracleum sibiricum L.
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Cat. No.: HY-122558
CAS No.: 1263409-34-2
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AM432 (sodium) is a potent and selective antagonist of the DP2 receptor (CRTH2). AM432 (sodium) exhibits excellent potency in a human whole blood eosinophil shape change assay with prolonged incubation. AM432 (sodium) also demonstrates excellent pharmacokinetics in dog and mouse models of inflammatory disease .
Cat. No.: HY-149738
CAS No.: 2408732-55-6
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FXh is a functionalized hapten activated by incubation with N, N′-disuccinimidyl carbonate, and Et3N in acetonitrile at 0 °C. FXh can improve the affinity of antigens .
Cat. No.: HY-113929
CAS No.: 106900-12-3
Synonyms: R-58425
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Loperamide oxide (R-58425) is a orally active prodrug of the Loperamide (HY-156131). Loperamide oxide incubation with the contents of the intestinal lumen inhibits fluid secretion under aerobic conditions .
Cat. No.: HY-172764
CAS No.: 1821706-67-5
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L-ENIPO (hydrochloride) is an inhibitor of iNOS, nNOS, and eNOS with Ki values of 17, 10.3, and 58.2 μM. L-ENIPO (hydrochloride) exerts reversible tight binding inhibition selective for iNOS with longer incubation time .
Cat. No.: HY-130287
CAS No.: 90780-51-1
Synonyms: (±)16-HDoHE; 16-hydroxy Docosahexaenoic acid; (±)16-HDoHE
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(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
