Loperamide oxide
Loperamide oxide (R-58425) is a orally active prodrug of the Loperamide (HY-156131). Loperamide oxide incubation with the contents of the intestinal lumen inhibits fluid secretion under aerobic conditions.
For research use only. We do not sell to patients.
- CAS No.: 106900-12-3
- Formula: C29H33ClN2O3
- Molecular Weight:493.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 106900-12-3
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Molecular Weight 493.04
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Formula C29H33ClN2O3
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SMILES
O=C(C(C1=CC=CC=C1)(CC[N@+]2(CC[C@](C3=CC=C(C=C3)Cl)(CC2)O)[O-])C4=CC=CC=C4)N(C)C
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Synonyms
R-58425
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : ≥ 100 mg/mL (202.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Hardcastle J, et al. The effect of loperamide oxide on prostaglandin-stimulated fluid transport in rat small intestine. J Pharm Pharmacol. 1990;42(5):364-366. [Content Brief]
[2]. Kamali F, Huang ML. Increased systemic availability of loperamide after oral administration of loperamide and loperamide oxide with cotrimoxazole. Br J Clin Pharmacol. 1996;41(2):125-128. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0282 mL | 10.1412 mL | 20.2823 mL | 50.7058 mL |
| 5 mM | 0.4056 mL | 2.0282 mL | 4.0565 mL | 10.1412 mL | |
| 10 mM | 0.2028 mL | 1.0141 mL | 2.0282 mL | 5.0706 mL | |
| 15 mM | 0.1352 mL | 0.6761 mL | 1.3522 mL | 3.3804 mL | |
| 20 mM | 0.1014 mL | 0.5071 mL | 1.0141 mL | 2.5353 mL | |
| 25 mM | 0.0811 mL | 0.4056 mL | 0.8113 mL | 2.0282 mL | |
| 30 mM | 0.0676 mL | 0.3380 mL | 0.6761 mL | 1.6902 mL | |
| 40 mM | 0.0507 mL | 0.2535 mL | 0.5071 mL | 1.2676 mL | |
| 50 mM | 0.0406 mL | 0.2028 mL | 0.4056 mL | 1.0141 mL | |
| 60 mM | 0.0338 mL | 0.1690 mL | 0.3380 mL | 0.8451 mL | |
| 80 mM | 0.0254 mL | 0.1268 mL | 0.2535 mL | 0.6338 mL | |
| 100 mM | 0.0203 mL | 0.1014 mL | 0.2028 mL | 0.5071 mL |
Loperamide oxide Related Classifications
HY-113929 Related Classifications
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