Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
72 Results for "
Janus
" in MedChemExpress (MCE) Product Catalog:
Products (72)
72 Results for "Janus" in MCE Product Catalog:
29
Target:
Research Areas:
Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research .
4
4
4 Cited Publications
Cat. No.: HY-P700583
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAK1; JTK3; Prev. JAK1B; JAK1 Protein; JAK1A; AIIDE; Tyrosine-Protein Kinase JAK1; JAK-1; Janus Kinase 1; Tyrosine-Protein Kinase
Species:
Human
Source:
P. pastoris
3
Target:
Research Areas:
Brepocitinib (PF-06700841) is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively .
3
3 Cited Publications
Synonyms: PF-06700841 P-Tosylate
Target:
Research Areas:
Brepocitinib (PF-06700841) P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib P-Tosylate also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively .
3
1
Target:
Research Areas:
Upadacitinib (Standard) is the analytical standard of Upadacitinib. This product is intended for research and analytical applications. Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research .
1
1
1 Cited Publications
Cat. No.: HY-P701102
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAK2; JAK-2; Janus Kinase 2; Janus Kinase 2 (A Protein Tyrosine Kinase); JTK10; Tyrosine-Protein Kinase; Tyrosine-Protein Kinase JAK2; Janus Kinase
Species:
Human
Source:
E. coli
1
Cat. No.: HY-50856S
CAS No.: 1513883-39-0
Synonyms: CTP-543; Ruxolitinib-d8; INCB18424-d8
Target:
Research Areas:
Deuruxolitinib (CTP-543; Ruxolitinib-d8) is a deuterated analog of Ruxolitinib (HY-50856) and an orally active, selective inhibitor of JAK1 and JAK2. Deuruxolitinib blocks Janus kinase-mediated cytokine receptor signaling and proinflammatory cytokine gene expression. Deuruxolitinib is primarily metabolized in the liver via CYP2C9. Deuruxolitinib promotes scalp hair regrowth in severe chronic alopecia areata. Deuruxolitinib is used in alopecia areata-related research .
Target:
Research Areas:
JAK3-IN-6 is a potent, selective irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM.
Cat. No.: HY-N2521
CAS No.: 52328-97-9
Synonyms: FLLL31
Synonyms: PG-011
Target:
Research Areas:
Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib shows anti-inflammatory activity .
Target:
Research Areas:
Lepzacitinib is a Janus kinase inhibitor targeting to JAK 1/3. Lepzacitinib exhibits anti-inflammatory effect and inhibits atopic dermatitis and other skin diseases .
Cat. No.: HY-159827
CAS No.: 2641636-52-2
Target:
Research Areas:
Cenacitinib is a potent Janus kinase inhibitor. Cenacitinib shows anti-inflammatory activity .
Cat. No.: HY-19569A
CAS No.: 1607431-21-9
Synonyms: ABT-494 tartrate tetrahydrate
Target:
Research Areas:
Upadacitinib (ABT-494) tartrate tetrahydrate is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib tartrate tetrahydrate displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib tartrate tetrahydrate can be used for several autoimmune disorders research .
Cat. No.: HY-119935
CAS No.: 2300106-50-5
Target:
Research Areas:
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
