15 Results for "

LGR5

" in MedChemExpress (MCE) Product Catalog:
Products (15)

15 Results for "LGR5" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P79308
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Leucine-rich repeat-containing G-protein coupled receptor 5; LGR5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; GPR49; GPR67; Leucine-rich Repeat Containing G Protein-coupled Receptor 5
Species:  
Source:  
CHO
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Cat. No.: HY-P99406
CAS No.: 2213450-26-9
Synonyms: MCLA 158

Target:  

EGFR

Research Areas:  

Cancer

Petosemtamab (MCLA 158) is an anti- EGFR (Kd: 0.22 nM) and anti-LGR5 (Kd: 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC) .
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Cat. No.: HY-P10810
Target:  

Wnt β-catenin

Research Areas:  

Cancer

QPH-FR is a LGR5 inhibitor. QPH-FR competitively binds to LGR5 and prevents the formation of the LGR5/RSPO1 complex. QPH-FR promotes RNF43/ZNRF3-mediated ubiquitination of FZD receptors, inhibits the Wnt β-catenin signaling pathway, and reduces the stemness of colorectal cancer cells. QPH-FR is applicable to relevant research on colorectal cancer .
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Cat. No.: HY-P99406A

Target:  

EGFR

Research Areas:  

Cancer

Petosemtamab (FUT8-KO) is an anti-EGFR and anti-LGR5 monoclonal antibody expressed in CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucosyl loss enhances the ADCC effect of the antibody. Petosemtamab (FUT8-KO) leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab (FUT8-KO) can be used for research on solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC) .
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Cat. No.: HY-P991454

Target:  

Wnt

Research Areas:  

Inflammation/Immunology

Anti-LGR5/GPR49 Antibody (18G7H6A3) is a human monoclonal antibody (mAb) targeting LGR5/GPR49. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P990560

Target:  

Wnt

Research Areas:  

Cancer

BNC-101 is a humanized monoclonal antibody targeting GPR49/LGR5. BNC-101 binds to LGR5, thereby inhibiting LGR5-mediated signal transduction pathways. BNC-101 has antineoplastic activity .
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Cat. No.: HY-RS07619
Research Areas:  

Others

LGR5 Human Pre-designed siRNA Set A contains three designed siRNAs for LGR5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS20763
Research Areas:  

Others

Lgr5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lgr5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS27277
Research Areas:  

Others

Lgr5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lgr5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P82097
Synonyms: FEX; GPR49; GPR67; GRP49; LGR5; HG38; 8

Host:  

Rabbit

Application:  

WB, IP, FC

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P700891
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; GPR49; GPR67; HG38; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
Species:  
Source:  
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Cat. No.: HY-P704758
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; GPR49; GPR67; HG38; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
Species:  
Source:  
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Cat. No.: HY-P706156
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; GPR49; GPR67; HG38; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
Species:  
Source:  
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Cat. No.: HY-P704759
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; GPR49; GPR67; HG38; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
Species:  
Source:  
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Cat. No.: HY-186001
CAS No.: 2922732-38-3
Synonyms: RM-044
Target:  

Ras β-catenin

Research Areas:  

Cancer

RMC-9945 (RM-044) is a selective, covalent, and orally active RAS (ON) G12D inhibitor. RMC-9945 enhances the transcriptional activity of β-Catenin/TCF. RMC-9945 induces cell state transition, forcing metastatic colorectal cancer cells to switch from the Emp1 + state to the Lgr5 + stem cell-like state. RMC-9945 achieves durable disease control in preclinical models of colorectal cancer with early liver metastasis, but shows reduced activity in late-stage metastasis models. RMC-9945 can be used in research related to metastatic colorectal cancer and pancreatic ductal adenocarcinoma .
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