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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
LGR5
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "LGR5" in MCE Product Catalog:
2
2 Cited Publications
FzM1.8 is a Wnt/β-catenin signaling pathway agonist and an allosteric agonist of Frizzled 4 (FZD4), with a pEC50 of 6.4 for FZD4 . FzM1.8 stabilizes a conformation with increased affinity for heterotrimeric G proteins, promoting Gβγ release and subsequent PI3K activation. FzM1.8 activates the AKT pathway downstream of FZD4. FzM1.8 does not affect FZD4 maturation or plasma membrane localization and does not induce FZD4 endocytosis. FzM1.8 upregulates the WNT-responsive genes C-myc and Cyclin D1, while leaving lgr5 expression unchanged. FzM1.8 can be used for colon cancer research .
1
1 Cited Publications
Cat. No.: HY-P79308
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; G-Protein Coupled Receptor HG38; Prev. GPR49; G-Protein Coupled Receptor 49; Prev. GPR67; G-Protein Coupled Receptor 67; HG38; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5, Isoform CRA_b; FEX; Orphan G Protein-Coupled Receptor HG38; Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5; GRP49; Leucine Rich Repeat Containing G Protein-Coupled Receptor 5; G Protein-Coupled Receptor 49
Species:
Human
Source:
CHO
Cat. No.: HY-P99406
CAS No.: 2213450-26-9
Synonyms: MCLA 158
Cat. No.: HY-P10810
Cat. No.: HY-P99406A
Cat. No.: HY-P991454
Target:
Research Areas:
Cat. No.: HY-P990560
Cat. No.: HY-RS07619
Target:
Research Areas:
LGR5 Human Pre-designed siRNA Set A contains three designed siRNAs for LGR5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20763
Target:
Research Areas:
Lgr5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lgr5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27277
Target:
Research Areas:
Lgr5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lgr5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P700891
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; G-Protein Coupled Receptor HG38; Prev. GPR49; G-Protein Coupled Receptor 49; Prev. GPR67; G-Protein Coupled Receptor 67; HG38; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5, Isoform CRA_b; FEX; Orphan G Protein-Coupled Receptor HG38; L
Species:
Human
Source:
HEK293
Cat. No.: HY-P704758
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; G-Protein Coupled Receptor HG38; Prev. GPR49; G-Protein Coupled Receptor 49; Prev. GPR67; G-Protein Coupled Receptor 67; HG38; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5, Isoform CRA_b; FEX; Orphan G Protein-Coupled Receptor HG38; L
Species:
Human
Source:
HEK293
Cat. No.: HY-P704759
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; G-Protein Coupled Receptor HG38; Prev. GPR49; G-Protein Coupled Receptor 49; Prev. GPR67; G-Protein Coupled Receptor 67; HG38; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5, Isoform CRA_b; FEX; Orphan G Protein-Coupled Receptor HG38; L
Species:
Human
Source:
HEK293
Cat. No.: HY-P706156
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LGR5; G-Protein Coupled Receptor HG38; Prev. GPR49; G-Protein Coupled Receptor 49; Prev. GPR67; G-Protein Coupled Receptor 67; HG38; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5, Isoform CRA_b; FEX; Orphan G Protein-Coupled Receptor HG38; L
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-186001
CAS No.: 2922732-38-3
Synonyms: RM-044
RMC-9945 (RM-044) is a selective, covalent, and orally active RAS (ON) G12D inhibitor. RMC-9945 enhances the transcriptional activity of β-Catenin/TCF. RMC-9945 induces cell state transition, forcing metastatic colorectal cancer cells to switch from the Emp1 + state to the Lgr5 + stem cell-like state. RMC-9945 achieves durable disease control in preclinical models of colorectal cancer with early liver metastasis, but shows reduced activity in late-stage metastasis models. RMC-9945 can be used in research related to metastatic colorectal cancer and pancreatic ductal adenocarcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
