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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
LR cell
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "LR cell" in MCE Product Catalog:
Cat. No.: HY-137225
CAS No.: 706758-28-3
Synonyms: HTS07944SC
Target:
Research Areas:
HTS07944 (HTS07944SC, C3) is a potent modulator of laminin receptor (37 LR). HTS07944 (HTS07944SC, C3) possesses anti-cancer activity in PC-3 cells and activates Caspase 3/7 .
Cat. No.: HY-162939
Target:
Research Areas:
TB22 is a non-nucleoside inhibitor of DOT1LR231Q, possessing anticancer activity. TB22 inhibits the malignant phenotype of lung cancer cells carrying the R231Q mutation through the MAPK/ERK signaling pathway, and can be used for lung cancer research .
Cat. No.: HY-143445
CAS No.: 2882851-77-4
EGFR-IN-48 is a potent and orally active EGFR inhibitor with IC50s of 0.193 nM, 0.251 nM, 10.4 nM for EGFR d19/TM/CS, EGFR LR/TM/CS, EGFR WT, respectively. EGFR-IN-48 inhibits the proliferation of BaF3 EGFR del19/T790M/C797S and PC-9 EGFR del19/T790M/C797S cells with IC50s of 1.526, 66.7 nM, respectively .
Cat. No.: HY-P991969
Cat. No.: HY-P991770
Target:
Research Areas:
Cat. No.: HY-P71210
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PKLR; Pyruvate Kinase, Liver And Blood cell; Pyruvate Kinase L/R; Pyruvate Kinase Isozymes R/L; Pyruvate Kinase, Liver And RBC; Pyruvate Kinase Isozyme R/L; Red cell/Liver Pyruvate Kinase; Pyruvate Kinase Isoform 1; R-Type/L-Type Pyruvate Kinase; Pyruvate Kinase Type L; Pyruvate Kinase Isozymes L/R; Pyruvate Kinase; Pyruvate Kinase PKLR; CNSHA2; Pyruvate Kinase 1; PKRL; PK1; RPK; PKL
Species:
Human
Source:
HEK293
Cat. No.: HY-P700578
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PKLR; Pyruvate Kinase, Liver And Blood cell; Pyruvate Kinase L/R; Pyruvate Kinase Isozymes R/L; Pyruvate Kinase, Liver And RBC; Pyruvate Kinase Isozyme R/L; Red cell/Liver Pyruvate Kinase; Pyruvate Kinase Isoform 1; R-Type/L-Type Pyruvate Kinase; Pyruvate
Species:
Rat
Source:
P. pastoris
Cat. No.: HY-188349
HQY1480 is a potent EGFR PROTAC degrader with DC50 values of 0.7 nM (Ba/F3 LR/TM/CS cells) and 5.2 nM (PC9_TM cells). HQY1480 inhibits EGFR L858R/T790M/C797S HQY1480 with an IC50 of 1.7 nM. HQY1480 recruits CRBN to mediate ubiquitin-proteasome-dependent degradation of mutant EGFR. HQY1480 inhibits AKT, ERK, and MET phosphorylation, induces tumor apoptosis, and suppresses DNA replication and cell cycle gene programs. HQY1480 can be used for research on EGFR-mutant non-small cell lung cancer . EGFR L858R/T790M/C797S enzymatic activity inhibition IC50 = 1.7 nM
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
