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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
NB4
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "NB4" in MCE Product Catalog:
Cat. No.: HY-127130
CAS No.: 87099-85-2
Target:
Spicamycin, an adenine nucleoside antibiotic with antifungal and antitumor activities. Spicamycin is also a potent inducer of differentiation of myeloid leukemia cells. Spicamycin induces apoptosis in NB4 cells via down-regulation of Bcl-2 expression and modulation of PML protein .
Cat. No.: HY-N10764
CAS No.: 116368-90-2
Target:
Cat. No.: HY-162658
Leuxinostat is an inhibitor for HDAC with IC50 of 30 nM for hHDAC6. Leuxinostat inhibits the proliferation of cells THP1, K562, U937 and MEK1, induces apoptosis in leukemia cells NB4 and MOLT-4. Leuxinostat inhibits the expansion of hematopoietic stem cells and exhibits antileukemic activity in zebrafish models .
Cat. No.: HY-118761
CAS No.: 13100-69-1
Synonyms: 5,6-epoxy atRA; 5,6-epoxy RA
Target:
Research Areas:
all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s=77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). 5,6-epoxy RA (1 μM) also induces growth arrest of MCF-7 and NB4 cells in vitro. It is a natural metabolite of all-trans retinoic acid, which is a metabolite of vitamin A.
Cat. No.: HY-180495
CAS No.: 155639-13-7
Synonyms: 5MT-NB4B
Target:
Research Areas:
5-MeO-NBpBrT (Compound 2f) (5MT-NB4B) is a NBOMe derivative and 5MT-based N-(bromobenzyl) isomer .
Cat. No.: HY-172399
Research Areas:
FTO-IN-14 (Compound F97) is the inhibitor for the RNA demethylase Fat mass and obesity-associated protein FTO with IC50 of 0.45 μM. FTO-IN-14 regulates the protein expression of ASB2, RARA and MYC. FTO-IN-14 exhibits antiproliferative activity in AML cancer cells (IC50 for MOLM13, NB4, HEL, OCI-AML3, MV4-11 and MONOMAC6 is 0.7-5.5 μM), induces apoptosis in NB4 cell. FTO-IN-14 exhibits antitumor activity in mouse NB4 xenograft models .
Cat. No.: HY-144755
CAS No.: 2771425-46-6
Target:
Research Areas:
MC2652 (compound 1a) is a potent LSD1 inhibitor. MC2652 displays high inhibiting effects in MV4-11 and NB4 leukaemia cells. MC2652 shows antiproliferative activity against prostate cancer LNCaP cells .
Cat. No.: HY-W965550
CAS No.: 83800-90-2
Apoptosis inducer 40 is an apoptosis inducer. Apoptosis inducer 40 exhibits potent cytotoxic effects against jurkat and NB4 cells with IC50 values of 4.5 μM and 3.6μM. Apoptosis inducer 40 induces apoptosis and arrests cell cycle. Apoptosis inducer 40 can be used for the research of cancer, such as acute myeloid leukemia (AML) .
Cat. No.: HY-149522
CAS No.: 3034883-70-7
Target:
Research Areas:
BCL6-IN-10 (Compound WK499) is a BCL6 inhibitor. BCL6-IN-10 interrupts the binding of BCL6 to SMRT protein. BCL6-IN-10 induces cell apoptosis, cell cycle arrest and DNA damage. BCL6-IN-10 inhibits AML cell proliferation (IC50s: 0.91, 1.63, 1.026, 7.42, 0.87, 0.85μM for OCl-AML3, THP1, MOLM13, HL60, KG1, NB4 cell respectively) .
Cat. No.: HY-P76556
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PTPMT1; DUSP23; Protein Tyrosine Phosphatase Mitochondrial 1; Phosphoinositide Lipid Phosphatase; PLIP; NB4 Apoptosis/Differentiation Related Protein; MOSP; Protein-Tyrosine Phosphatase Mitochondrial 1; Phosphatidylglycerophosphatase And Protein-Tyrosine
Species:
Human
Source:
E. coli
Cat. No.: HY-170683
CAS No.: 1566571-54-7
Target:
Research Areas:
25H-NB4OMe hydrochloride is a phenethylamine.
Cat. No.: HY-172068
CAS No.: 1566571-56-9
Target:
Research Areas:
25B-NB4OMe hydrochloride is structurally categorized as a phenethylamine.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
