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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
NBC
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "NBC" in MCE Product Catalog:
4
4 Cited Publications
Target:
Research Areas:
S0859 is a selective, high-affinity generic Na +/HCO3 - transporter (NBC) inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM).
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NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. NBC19 inhibits nigericin- and ATP-induced IL-1β release with IC50s of 80 nM and 850 nM, respectively .
Cat. No.: HY-131040
CAS No.: 2068818-02-8
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NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca 2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) .
Cat. No.: HY-W035106
CAS No.: 13927-77-0
Synonyms: NBC
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Nickel(II) Dibutyldithiocarbamate is an antioxidant and antiozonant. Nickel(II) Dibutyldithiocarbamate can be used against ozone-induced bronzing of P. vulgaris leaves .
Cat. No.: HY-165407
CAS No.: 99453-84-6
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Neltenexine is a mucolytic agent and an inhibitor of anion hypersecretion. Neltenexine acts on NKCC1, NBC1 and AE2 transporters located on the basolateral membrane of airway epithelial cells . Neltenexine reduces Cl -/HCO3 - uptake by inhibiting NKCC1 and NBC1, activates AE2 to promote Cl - excretion, reduces β2-adrenergic agonist-induced anion hypersecretion without blocking CFTR channels, and maintains appropriate airway fluid levels . Neltenexine can be used in research related to chronic obstructive pulmonary disease and emphysema .
Cat. No.: HY-P703252
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC4A4; Pancreatic Sodium Bicarbonate Cotransporter; Prev. SLC4A5; Na(+)/HCO3(-) Cotransporter; KNBC1; Sodium Bicarbonate Cotransporter 1 (Sodium Bicarbonate Cotransporter, Kidney; Sodium Bicarbonate Cotransporter, Pancreas); NBC1; Solute Carrier Family 4
Species:
Human
Source:
HEK293
Cat. No.: HY-RS19074
Target:
Research Areas:
Slc4a4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc4a4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-165407A
CAS No.: 99461-80-0
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Research Areas:
Neltenexine hydrochloride is a mucolytic agent and an inhibitor of anion hypersecretion. Neltenexine hydrochloride acts on NKCC1, NBC1 and AE2 transporters located on the basolateral membrane of airway epithelial cells . Neltenexine hydrochloride reduces Cl -/HCO3 - uptake by inhibiting NKCC1 and NBC1, activates AE2 to promote Cl - excretion, reduces β2-adrenergic agonist-induced anion hypersecretion without blocking CFTR channels, and maintains appropriate airway fluid levels . Neltenexine hydrochloride can be used in research related to chronic obstructive pulmonary disease and emphysema .
Cat. No.: HY-P89587
Synonyms: NBC, NBC1, NBCE1, SLC4A4, Electrogenic sodium bicarbonate cotransporter 1, Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4, kNBC1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
