223 Results for "

NF-κB phosphorylation

" in MedChemExpress (MCE) Product Catalog:
Products (223)

223 Results for "NF-κB phosphorylation" in MCE Product Catalog:

488
BAY 11-7082
BAY 11-7082
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488 Publications Verification
Cat. No.: HY-13453
CAS No.: 19542-67-7
Purity:  99.98%
Synonyms: BAY 11-7821
Target:  

IKK Deubiquitinase Autophagy Apoptosis NF-κB

Research Areas:  

Inflammation/Immunology Cancer

BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .
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111
Tauroursodeoxycholate dihydrate
Tauroursodeoxycholate dihydrate
0 Images
111 Cited Publications
Cat. No.: HY-19696B
CAS No.: 117609-50-4
Synonyms: Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate
Category:  

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt

Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .
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51
BAY 11-7085
BAY 11-7085
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51 Cited Publications
Cat. No.: HY-10257
CAS No.: 196309-76-9
Purity:  99.85%
Synonyms: BAY 11-7083
Target:  

NF-κB Ferroptosis Apoptosis

Research Areas:  

Cancer

BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM .
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17
Maslinic acid
Maslinic acid
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17 Cited Publications
Cat. No.: HY-N0629
CAS No.: 4373-41-5
Synonyms: Crategolic acid; 2α-Hydroxyoleanolic acid
Category:  

Triterpenes other families Terpenoids Plants Disease Research Fields Cancer

Target:  

NF-κB Bacterial HIV Endogenous Metabolite

Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.
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16
Ginsenoside Rb1
Ginsenoside Rb1
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16 Cited Publications
Cat. No.: HY-N0039
CAS No.: 41753-43-9
Synonyms: Gypenoside III
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Araliaceae Cancer

Target:  

Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV

Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na +, K +-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .
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12
Sophocarpine
Sophocarpine
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12 Cited Publications
Cat. No.: HY-N0103
CAS No.: 6483-15-4
Category:  

Infection Alkaloids Piperidine Alkaloids Leguminosae Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology

Target:  

Autophagy Apoptosis NF-κB PI3K Akt MEK ERK PTEN

Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage .
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12
Sophocarpine monohydrate
Sophocarpine monohydrate
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12 Cited Publications
Cat. No.: HY-N0103A
CAS No.: 145572-44-7
Category:  

Infection Alkaloids Piperidine Alkaloids Leguminosae Sophora japonica L. Plants Disease Research Fields Inflammation/Immunology

Target:  

Autophagy Apoptosis NF-κB PI3K Akt MEK ERK

Sophocarpine monohydrate is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine monohydrate upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine monohydrate inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine monohydrate can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine monohydrate has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage .
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12
Licochalcone B
Licochalcone B
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12 Cited Publications
Cat. No.: HY-N0373
CAS No.: 58749-23-8
Category:  

Flavonoids Chalcones Leguminosae Plants Glycyrrhiza uralensis Fisch.

Target:  

Amyloid-β Apoptosis NOD-like Receptor (NLR)

Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .
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11
Angelicin
Angelicin
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11 Cited Publications
Cat. No.: HY-N0763
CAS No.: 523-50-2
Synonyms: Isopsoralen
Category:  

Leguminosae Coumarins Psoralea corylifolia L. Phenylpropanoids Plants Disease Research Fields Cancer

Target:  

Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase

Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC50=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.
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8
Homoplantaginin
Homoplantaginin
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8 Cited Publications
Cat. No.: HY-N1949
CAS No.: 17680-84-1
Category:  

Flavonoids Flavones Labiatae Cassia Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers TNF Receptor NF-κB

Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.
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8
Gamma-Linolenic acid
Gamma-Linolenic acid
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8 Cited Publications
Cat. No.: HY-N7140
CAS No.: 506-26-3
Synonyms: γ-Linolenic acid
Category:  

Labiatae Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Tadehagi triquetrum (L.) Ohashi Plants Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Apoptosis NF-κB ERK JNK

Gamma-linolenic acid (γ-Linolenic acid) is an orally active unsaturated fatty acid. Gamma-linolenic acid exerts anti-inflammatory effects by inhibiting the NF-κB pathway and the phosphorylation of ERK1/2 and JNK. At the same time, it exerts anticancer effects by inducing apoptosis (Apoptosis) in cancer cells. Additionally, Gamma-linolenic acid also has antioxidant and memory-improving effects. It holds promise for research in the fields of inflammation, neurology, and cancer diseases .
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5
Mulberroside A
Mulberroside A
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5 Cited Publications
Cat. No.: HY-N0619
CAS No.: 102841-42-9
Category:  

Stilbenes Morus alba L. Phenols Polyphenols Plants Moraceae Disease Research Fields Inflammation/Immunology

Target:  

TNF Receptor Interleukin Related Tyrosinase

Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM .
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5
IAXO-102
IAXO-102
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5 Cited Publications
Cat. No.: HY-125171
CAS No.: 1115270-63-7
Purity:  ≥98.0%
Target:  

Toll-like Receptor (TLR)

Research Areas:  

Inflammation/Immunology

IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .
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5
[10]-Shogaol
[10]-Shogaol
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5 Cited Publications
Cat. No.: HY-N2434
CAS No.: 36752-54-2
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Disease Research Fields Cancer Zingiberaceae

Target:  

COX Interleukin Related NF-κB Parasite

[10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis .
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4
Sipeimine
Sipeimine
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4 Cited Publications
Cat. No.: HY-N0696
CAS No.: 61825-98-7
Synonyms: Imperialine
Category:  

Alkaloids Piperidine Alkaloids Liliaceae Other Diseases Plants Fritillaria ussuriensis Maxim. Disease Research Fields

Target:  

PI3K NF-κB Akt NOD-like Receptor (NLR) Pyroptosis Ferroptosis

Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases .
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4
TRAF-STOP inhibitor 6877002
TRAF-STOP inhibitor 6877002
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4 Cited Publications
Cat. No.: HY-110247
CAS No.: 433249-94-6
Purity:  99.67%
Target:  

TNF Receptor NF-κB

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

TRAF-STOP inhibitor 6877002 is a selective CD40-TRAF6 interaction inhibitor. TRAF-STOP inhibitor 6877002 exerts anti-atherosclerotic activity by blocking the CD40-TRAF6 signaling pathway, inhibiting classical monocyte activation, leukocyte recruitment, and macrophage activation and migration. TRAF-STOP inhibitor 6877002 reduces the phosphorylation levels of signaling intermediates in the canonical NF-κB pathway .
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4
Curcumenol
Curcumenol
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4 Cited Publications
Cat. No.: HY-N2259
CAS No.: 19431-84-6
Synonyms: (+)-Curcumenol
Category:  

Neurological Disease Terpenoids Sesquiterpenes Plants Curcuma phaeocaulis Valeton Disease Research Fields Inflammation/Immunology Cancer Zingiberaceae

Target:  

Cytochrome P450 NF-κB MMP Interleukin Related TNF Receptor Akt p38 MAPK Ferroptosis Apoptosis CXCR COX Caspase Bcl-2 Family TGF-β Receptor

Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis .
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4
Isorhapontigenin
Isorhapontigenin
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4 Cited Publications
Cat. No.: HY-N2593
CAS No.: 32507-66-7
Category:  

Stilbenes Gnetum cleistostachyum C. Y. Cheng Gnetaceae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes .
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3
4'-Hydroxychalcone
4'-Hydroxychalcone
0 Images
3 Cited Publications
Cat. No.: HY-N7056
CAS No.: 2657-25-2
Category:  

Plants Endogenous metabolite Flavonoids Chalcones Monophenols Leguminosae Phenols Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Target:  

Oxidative Phosphorylation Proteasome

4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria .
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3
p-Synephrine
p-Synephrine
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3 Cited Publications
Cat. No.: HY-113236
CAS No.: 614-35-7
Purity:  98.04%
Category:  

Citrus × aurantium Linnaeus Rutaceae Plants Endogenous metabolite Alkaloids Monophenols Other Alkaloids Other Diseases Phenols Disease Research Fields

Target:  

Adrenergic Receptor AMPK GLUT p38 MAPK NF-κB

p-Synephrine is an orally active alkaloid dietary supplement without indirect sympathomimetic activity or cardiovascular stimulatory activity. p-Synephrine stimulates AMPK phosphorylation and mediates Glut4 translocation to increase glucose consumption and lactate production in skeletal muscle cells. p-Synephrine also downregulates the p38 MAPK and NF-κB signaling pathways to inhibit pro-inflammatory cytokine production and alter oxidative metabolism. p-Synephrine exhibits low subchronic toxicity in mice. p-Synephrine can be applied to research related to systemic inflammatory response syndrome, obesity, and type 2 diabetes .
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