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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
Nedd4
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "Nedd4" in MCE Product Catalog:
3
3 Cited Publications
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研究分野:
Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits Smurf2, Nedd4, WWP1 (IC50 values are 6.8, 6.3, 6.9 μM) and can be used for the research of gastric cancer .
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製品番号: HY-162809
CAS 番号: 2251130-41-1
XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used for the study of colon, lung and pancreatic cancer .
製品番号: HY-N10159
CAS 番号: 60941-76-6
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製品番号: HY-RS09179
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研究分野:
NEDD4 Human Pre-designed siRNA Set A contains three designed siRNAs for NEDD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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NAB2 is a neuroprotectant that targets the small GTPase Rab1a. NAB2 selectively binds to the GDP-bound form of Rab1a and protects multiple cell types from α-synuclein toxicity by increasing Rab1a expression. Rab1a regulates ER-to-Golgi trafficking and mediates endosomal trafficking events of the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 stimulates ubiquitination of related proteins in a Nedd4-dependent manner and rescues α-synuclein-associated trafficking defects associated with early-onset Parkinson's disease .
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研究分野:
HECT E3-IN-1 (compound 3) is a HECT E3 ligase inhibitor. HECT E3-IN-1 (compound 3) disrupts Ub binding to the noncovalent Ub-binding site of Nedd4-1 .
製品番号: HY-RS17232
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研究分野:
Nedd4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nedd4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds .
製品番号: HY-RS23685
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研究分野:
Nedd4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nedd4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS09180
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研究分野:
NEDD4L Human Pre-designed siRNA Set A contains three designed siRNAs for NEDD4L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-124791
CAS 番号: 709009-15-4
MMRi6 is a Mdm2-MdmX RING domain inhibitor that can disrupt Mdm2-MdmX RING-RING interaction in vitro. MMRi6 inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated p53 polyubiquitination in vitro without affecting NEDD4-1 autoubiquitination. MMRi6 induces p53 stabilization and accumulation and induces PARP cleavage in wt-p53 Emu-myc lymphoma cells. MMRi6 inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells with IC50s of approximately 0.5 μM and 3 μM, respectively. MMRi6 can be used for the study of leukemia/lymphoma .
製品番号: HY-179570
CAS 番号: 2251132-02-0
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研究分野:
XMU-MP-10 is a selective NEDD4 inhibitor with a KD of 43.92 nM. XMU-MP-10 selectively inhibits NEDD4 auto-ubiquitination without affecting other ubiquitination activity, upregulates of β-TrCP and results YAP degradation without affecting NEDD4 protein expression. XMU-MP-10 exhibits significant in vivo efficacy in inhibiting TNBC tumor growth by enhancing CD8 + T cell infiltration. XMU-MP-10 enhances antitumor immune responses through the β-TrCP/YAP/ECM axis. XMU-MP-10 can be used for Triple-Negative Breast Cancer (TNBC) research .
製品番号: HY-P88005
別名: KIAA0093, Nedd4-1, RPF1, PIG53, Nedd4, E3 ubiquitin-protein ligase Nedd4, Cell proliferation-inducing gene 53 protein, HECT-type E3 ubiquitin transferase Nedd4, Neural precursor cell expressed developmentally down-regulated protein 4, Nedd-4
製品番号: HY-P86985
別名: E3 ubiquitin protein ligase Nedd4 like protein antibody; E3 ubiquitin-protein ligase Nedd4-like antibody; KIAA0439 antibody; NED4L_HUMAN antibody; Nedd4 2 antibody; Nedd4-2 antibody; Nedd4 2c antibody; Nedd4-2 antibody; Nedd4-2a antibody; Nedd4.2 antibody; E3 ubiquitin protein ligase Nedd4 like protein antibody; E3 ubiquitin-protein ligase Nedd4-like antibody; KIAA0439 antibody; NED4L_HUMAN antibody; Nedd4 2 antibody; Nedd4-2 antibody; Nedd4 2c antibody; Nedd4-2 antibody; Nedd4-2a antibody; Nedd4.2 antibody; Nedd4b antibody; Nedd4L antibody; Nedd4La antibody; Nedd4Lb antibody; Nedd4Lc antibody; Nedd4Ld antibody; Nedd4Le antibody; Nedd4Lf antibody; Nedd4Lg antibody; Nedd4Lh antibody; NEDL3 antibody; Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase antibody; Neural precursor cell expressed, developmentally down regulated 4 like antibody; RSP5 antibody; Ubiquitin protein ligase Rsp5 antibody;
製品番号: HY-RS17116
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研究分野:
Nedd4l Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nedd4l gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS23561
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研究分野:
Nedd4l Rat Pre-designed siRNA Set A contains three designed siRNAs for Nedd4l gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-P701595
純度: ≥ 85%, as determined by reducing SDS-PAGE.
別名: Nedd4L; E3 ubiquitin-protein ligase Nedd4-like; HECT-type E3 ubiquitin transferase NED4L; Nedd4.2; Nedd4-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
