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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
P-Sam
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "P-Sam" in MCE Product Catalog:
Cat. No.: HY-171689
CAS No.: 2760250-80-2
Synonyms: AZD 8205; P-Sam
Domaines de recherche:
Puxitatug samrotecan (AZD 8205) is an antibody-drug conjugate (ADC) targeting B7-H4, formed by the random conjugation of the Puxitatug (HY-P990059) antibody and AZ14170133 (HY-145399) via interchain cysteine reduction. Puxitatug samrotecan binds to B7-H4 to deliver the payload to B7-H4-expressing cells, inhibits topoisomerase I, and induces cytotoxicity in cancer cells and xenograft models. Puxitatug samrotecan can be used in studies of B7-H4-expressing tumors .
Cat. No.: HY-115514A
CAS No.: 2250025-98-8
BRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC50 of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC50 of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models .
Cat. No.: HY-161182
CAS No.: 2341841-08-3
Target:
Domaines de recherche:
uPSEM792 hydrochloride is a PSEM agonist of PSAM 4-GlyR with blood-brain barrier permeability, activating PSAM 4-GlyR to silence neuronal activity. uPSEM792 hydrochloride produces dose-dependent neuronal silencing effects in ex vivo retinal preparations, inhibiting calcium signaling responses in COMS‑AC amacrine cells. uPSEM792 hydrochloride flattens interstitial ion waves in hippocampal neurons expressing PSAM-GlyR and impairs cerebrospinal fluid perfusion and molecular clearance. uPSEM792 hydrochloride can be used for research on nervous system-related diseases .
Cat. No.: HY-161246
CAS No.: 2323525-19-3
Target:
Domaines de recherche:
uPSEM792 is a PSEM agonist of PSAM 4-GlyR with blood-brain barrier permeability, activating PSAM 4-GlyR to silence neuronal activity. uPSEM792 produces dose-dependent neuronal silencing effects in ex vivo retinal preparations, inhibiting calcium signaling responses in COMS‑AC amacrine cells. uPSEM792 flattens interstitial ion waves in hippocampal neurons expressing PSAM-GlyR and impairs cerebrospinal fluid perfusion and molecular clearance. uPSEM792 can be used for research on nervous system-related diseases .
Cat. No.: HY-136232
Target:
Domaines de recherche:
PSEM 308 hydrochloride is a pharmacologically selective actuator module (PSAM) agonist. PSEM 308 Activates PSAML141F-GlyR chimeric ion channels .
Cat. No.: HY-181351
Target:
Domaines de recherche:
PSN09 is a blood-brain barrier-permeable agonist of PSAM 4-GlyR and PSAM 4-5-HT3 receptors with high affinity. 18F-labeled PSN09 serves as a radiotracer for PET imaging in non-human primates .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
